{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T21:45:01Z","timestamp":1777585501978,"version":"3.51.4"},"reference-count":21,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Clin Med Insights Endocrinol Diabetes"],"published-print":{"date-parts":[[2011,1]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To present a case of hypercalcemia associated with thyrotoxicosis in a patient with vitamin D deficiency and review biochemical changes during the course of treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We report a case, describe the changes in serum calcium, phosphorus, parathyroid hormone in Graves\u2019 disease and concomitant Vitamin D deficiency. We compare our findings to those reported in literature.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Our patient had hypercalcemia secondary to thyrotoxicosis alone, which was confirmed by low parathyroid hormone level and resolution of hypercalcemia with treatment of thyrotoxicosis. The case was complicated by a concomitant vitamin D deficiency. Serum calcium elevation in patients with thyrotoxicosis occurs secondary to hyperthyroidism alone or due to concurrent hyperparathyroidism. Hypercalcemia from thyrotoxicosis is usually asymptomatic and is related to bone resorption. Vitamin D deficiency can be seen in patients with thyrotoxicosis because of accelerated metabolism, poor intestinal absorption and increased demand during bone restoration phase. Coexistence of hypercalcemia and Vitamin D deficiency in patients with thyrotoxicosis is rare, but possible, and 25-hydroxyvitamin D levels should be checked. The definite treatment for hypercalcemia in thyrotoxicosis is correction of thyroid function.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Hypercalcemia in thyrotoxicosis should be distinguished from concomitant hyperparathyroidism and confirmed by resolution of hypercalcemia with control of thyrotoxicosis. Patients with hypercalcemia and thyrotoxicosis may also have vitamin D deficiency and 25-OH Vitamin D levels should be checked.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4137\/cmed.s7116","type":"journal-article","created":{"date-parts":[[2011,5,31]],"date-time":"2011-05-31T18:20:14Z","timestamp":1306866014000},"page":"CMED.S7116","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":10,"title":["An Unusual Case of Hypercalcemia Associated with Graves\u2019 Disease and Vitamin D Deficiency"],"prefix":"10.4137","volume":"4","author":[{"given":"Evgenia","family":"Korytnaya","sequence":"first","affiliation":[{"name":"Department of Medicine, Albert Einstein Medical Center, philadelphia, PA, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nagashree Gundu","family":"Rao","sequence":"additional","affiliation":[{"name":"Department of Medicine, Albert Einstein Medical Center, philadelphia, PA, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jane V.","family":"Mayrin","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Albert Einstein Medical Center, philadelphia, PA, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2011,6,1]]},"reference":[{"key":"bibr1-CMED.S7116","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-65-3-429"},{"key":"bibr2-CMED.S7116","doi-asserted-by":"publisher","DOI":"10.1007\/BF01478206"},{"key":"bibr3-CMED.S7116","doi-asserted-by":"publisher","DOI":"10.4158\/EP.9.6.517"},{"key":"bibr4-CMED.S7116","doi-asserted-by":"publisher","DOI":"10.1016\/S0889-8529(18)30338-4"},{"key":"bibr5-CMED.S7116","doi-asserted-by":"publisher","DOI":"10.1016\/0026-0495(82)90123-8"},{"key":"bibr6-CMED.S7116","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2265.2002.01578.x"},{"key":"bibr7-CMED.S7116","doi-asserted-by":"publisher","DOI":"10.1016\/0306-9877(77)90055-X"},{"key":"bibr8-CMED.S7116","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-84-6-668"},{"key":"bibr9-CMED.S7116","first-page":"1","volume":"36","author":"Adams P.H.","year":"1967","journal-title":"Quaterly Journal of Medicine."},{"key":"bibr10-CMED.S7116","first-page":"313","volume":"27","author":"Parsons V.","year":"1964","journal-title":"Clinical Science."},{"key":"bibr11-CMED.S7116","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/80.6.1689S"},{"key":"bibr12-CMED.S7116","doi-asserted-by":"publisher","DOI":"10.1080\/07315724.2003.10719287"},{"key":"bibr13-CMED.S7116","doi-asserted-by":"publisher","DOI":"10.4065\/81.3.353"},{"key":"bibr14-CMED.S7116","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra070553"},{"key":"bibr15-CMED.S7116","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00336.2004"},{"key":"bibr16-CMED.S7116","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-006-0084-3"},{"key":"bibr17-CMED.S7116","first-page":"159","volume":"5","author":"Velentzas C.","year":"1983","journal-title":"Acta Vitamin Enzymol."},{"key":"bibr18-CMED.S7116","first-page":"995","volume":"51","author":"Haldimann B.","journal-title":"Journal of Clinical Endocrinology."},{"key":"bibr19-CMED.S7116","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-199902000-00012"},{"key":"bibr20-CMED.S7116","doi-asserted-by":"publisher","DOI":"10.1016\/0026-0495(85)90070-8"},{"key":"bibr21-CMED.S7116","doi-asserted-by":"publisher","DOI":"10.1007\/s12020-009-9211-1"}],"container-title":["Clinical Medicine Insights: Endocrinology and Diabetes"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/journals.sagepub.com\/doi\/pdf\/10.4137\/CMED.S7116","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/journals.sagepub.com\/doi\/full-xml\/10.4137\/CMED.S7116","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/journals.sagepub.com\/doi\/pdf\/10.4137\/CMED.S7116","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T20:00:33Z","timestamp":1777406433000},"score":1,"resource":{"primary":{"URL":"http:\/\/journals.sagepub.com\/doi\/10.4137\/CMED.S7116"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,1]]},"references-count":21,"alternative-id":["10.4137\/CMED.S7116"],"URL":"https:\/\/doi.org\/10.4137\/cmed.s7116","relation":{},"ISSN":["1179-5514","1179-5514"],"issn-type":[{"value":"1179-5514","type":"print"},{"value":"1179-5514","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,1]]}}}