{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T07:19:07Z","timestamp":1790752747202,"version":"4.1.0"},"reference-count":28,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Clin Med Insights Ear Nose Throat"],"published-print":{"date-parts":[[2013,1]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p> Language is almost always affected in fragile X syndrome (FXS), and a delay in language acquisition is one of the first characteristics. The aim of this work was to study the effect of recurrent middle ear infections on the language profile in boys with FXS. Study design: Prospective case series. <\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p> Academic Medical Center. <\/jats:p><\/jats:sec><jats:sec><jats:title>Subjects and Methods<\/jats:title><jats:p> The present study was conducted on 30 males, ranging in age from 4\u201310 years. They were diagnosed as having a full mutation of DNA. The males were divided into two groups: Group A included 15 children with a history of recurrent middle ear infections more than four times per year during the first 4 years of life, and Group B did not have a history of recurrent middle ear infections during the first 4 years of life. Language assessments were done for all participants using the Standardized Arabic Language test. <\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p> Results showed significant delays in language development in children with FXS. Relative strengths in semantics compared to syntax and pragmatics were observed in all boys. The recurrent ear infections of the boys played an important role in the language development delay. The mean of receptive, expressive, and total language age was better and higher among boys without a history of recurrent middle ear infections compared to boys with recurrent middle ear infections. <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p> Recurrent otitis media in boys with FXS exacerbates the language problems that exist in this syndrome. <\/jats:p><\/jats:sec>","DOI":"10.4137\/cment.s11157","type":"journal-article","created":{"date-parts":[[2013,2,6]],"date-time":"2013-02-06T20:24:01Z","timestamp":1360182241000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":6,"title":["Effect of Recurrent Otitis Media on Language Profile in Children with Fragile X Syndrome"],"prefix":"10.4137","volume":"6","author":[{"given":"Hatem Soliman","family":"Badran","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology-Head and Neck Surgery, Kasr Al-Aini School of Medicine, Cairo University, Cairo, Egypt."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khairy M.","family":"Abulnasr","sequence":"additional","affiliation":[{"name":"Hearing and Speech Institute, Egypt."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sherien Abd El Hameed","family":"Nasser","sequence":"additional","affiliation":[{"name":"Department of Children with Special Needs, National Research Center, Cairo, Egypt."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2013,2,6]]},"reference":[{"key":"bibr1-CMENT.S11157","doi-asserted-by":"publisher","DOI":"10.1097\/00125817-200109000-00006"},{"key":"bibr2-CMENT.S11157","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(91)90397-H"},{"key":"bibr3-CMENT.S11157","volume-title":"GeneReviews.","author":"Saul R.A."},{"key":"bibr4-CMENT.S11157","volume-title":"Handbook of Neurodevelopmental and Genetic Disorders in Children.","author":"Goldstein S.","year":"1999"},{"key":"bibr5-CMENT.S11157","doi-asserted-by":"crossref","first-page":"287","DOI":"10.56021\/9780801868436","volume-title":"Fragile X Syndrome: Diagnosis, Treatment and Research","author":"Hagerman R.J.","year":"2002","edition":"3"},{"issue":"7","key":"bibr6-CMENT.S11157","first-page":"674","volume":"139","author":"Hagerman R.J.","year":"1985","journal-title":"Am J Dis Child."},{"key":"bibr7-CMENT.S11157","first-page":"25","volume":"1","author":"Downs M.P.","year":"1980","journal-title":"Semin Speech Lang Hear."},{"key":"bibr8-CMENT.S11157","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2008-0317"},{"issue":"2","key":"bibr9-CMENT.S11157","first-page":"184","volume":"141","author":"Hagerman R.J.","year":"1987","journal-title":"Am J Dis Child."},{"key":"bibr10-CMENT.S11157","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320230114"},{"issue":"19","key":"bibr11-CMENT.S11157","first-page":"726","volume":"8","author":"Roberts J.","year":"2003","journal-title":"ASHA Lead."},{"key":"bibr12-CMENT.S11157","doi-asserted-by":"publisher","DOI":"10.1044\/jshr.3405.1106"},{"issue":"1","key":"bibr13-CMENT.S11157","first-page":"28","volume":"106","author":"American Psychiatric Association.","year":"1994","journal-title":"American Journal on Mental Retardation."},{"key":"bibr14-CMENT.S11157","volume-title":"Stanford-Binet Intelligent Scale Manual","author":"Terman L.","year":"1961","edition":"3"},{"key":"bibr15-CMENT.S11157","doi-asserted-by":"crossref","unstructured":"KotbyM., KhairyA., BarakaM. Language testing of Arabic speaking children. Proceedings of the XXIII World Congress of the International Association of the Logopedics and Phoniatrics, Cairo, Aug 1995.","DOI":"10.1159\/isbn.978-3-318-01868-4"},{"issue":"3","key":"bibr16-CMENT.S11157","first-page":"211","volume":"27","author":"Nielsen K.B.","year":"1983","journal-title":"J Ment Defic Res."},{"key":"bibr17-CMENT.S11157","doi-asserted-by":"publisher","DOI":"10.1044\/1092-4388(2005\/034)"},{"issue":"1","key":"bibr18-CMENT.S11157","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1542\/peds.77.1.57","volume":"77","author":"Bluestone C.D.","year":"1986","journal-title":"Pediatrics."},{"issue":"1","key":"bibr19-CMENT.S11157","first-page":"88","volume":"77","author":"Paradise J.L.","year":"1986","journal-title":"Pediatrics."},{"key":"bibr20-CMENT.S11157","doi-asserted-by":"publisher","DOI":"10.1044\/jshd.4502.143"},{"key":"bibr21-CMENT.S11157","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197905173002001"},{"issue":"4","key":"bibr22-CMENT.S11157","first-page":"640","volume":"71","author":"Bess F.","year":"1983","journal-title":"Pediatrics."},{"key":"bibr23-CMENT.S11157","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320230128"},{"key":"bibr24-CMENT.S11157","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1098-2779(1997)3:4<313::AID-MRDD6>3.0.CO;2-O"},{"key":"bibr25-CMENT.S11157","first-page":"71","volume-title":"The Fragile X Child.","author":"Schopmeyer B.B.","year":"1992"},{"key":"bibr26-CMENT.S11157","unstructured":"Harris-SchmidtG. What are some important teaching strategies? National Fragile X Foundation; 2005. Available from http:\/\/www.fragilex.org\/html\/teaching.htm. Accessed."},{"key":"bibr27-CMENT.S11157","doi-asserted-by":"publisher","DOI":"10.2466\/pms.1978.47.3.723"},{"issue":"2","key":"bibr28-CMENT.S11157","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1542\/peds.66.2.246","volume":"66","author":"Zinkus P.W.","year":"1980","journal-title":"Pediatrics."}],"container-title":["Clinical Medicine Insights: Ear, Nose and Throat"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.4137\/CMENT.S11157","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.4137\/CMENT.S11157","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.4137\/CMENT.S11157","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,16]],"date-time":"2024-10-16T02:38:28Z","timestamp":1729046308000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.4137\/CMENT.S11157"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,1]]},"references-count":28,"alternative-id":["10.4137\/CMENT.S11157"],"URL":"https:\/\/doi.org\/10.4137\/cment.s11157","relation":{},"ISSN":["1179-5506","1179-5506"],"issn-type":[{"value":"1179-5506","type":"print"},{"value":"1179-5506","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,1]]},"article-number":"CMENT.S11157"}}