{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T10:36:43Z","timestamp":1777891003549,"version":"3.51.4"},"reference-count":26,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Clin Med Insights Oncol"],"published-print":{"date-parts":[[2015,1]]},"abstract":"<jats:p>Hepatosplenic T-cell lymphoma (HSTCL) is a rare and aggressive extranodal T-cell lymphoma that comprises &lt;5% of peripheral T-cell lymphomas. The majority of cases harbor the \u03b3\u03b4T-cell receptor (TCR), but recently, a few cases have been shown to express the \u03b1\u00df TCR. Comparison of these two subtypes (\u03b1\u03b2 and \u03b3\u03b4) shows similar clinicopathologic and cytogenetic features; however, due to the paucity of reported cases, it is not clear whether they are prognostically distinct entities. We report a case of \u03b1\u03b2 HSTCL with a rather unusual presentation of Coombs'-negative hemolytic anemia. Diagnosis proved challenging due to an unusual blastoid morphology with the absence of typical intrasinusoidal distribution of tumor cells in the bone marrow. This unique case adds to the growing list of this rare subtype of T-cell lymphomas, which warrant urgent attention due to the lack of effective treatment options and dismal prognosis.<\/jats:p>","DOI":"10.4137\/cmo.s35120","type":"journal-article","created":{"date-parts":[[2015,12,2]],"date-time":"2015-12-02T17:15:11Z","timestamp":1449076511000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["An Unusual Case of Hepatosplenic \u03b1\u03b2 T-Cell Lymphoma Presenting with Coombs'-Negative Hemolytic Anemia"],"prefix":"10.4137","volume":"9","author":[{"given":"Feryal A.","family":"Ibrahim","sequence":"first","affiliation":[{"name":"Department of Laboratory Medicine and Pathology, National Center for Cancer Care and Research, Hamad Medical Corporation, Doha, Qatar."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vignesh","family":"Shanmugam","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine and Pathology, Weill Cornell Medical College in Qatar, Education City, Doha, Qatar."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aliaa","family":"Amer","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine and Pathology, National Center for Cancer Care and Research, Hamad Medical Corporation, Doha, Qatar."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Halima","family":"El-Omri","sequence":"additional","affiliation":[{"name":"Department of Hematology and Medical Oncology, National Center for Cancer Care and Research, Hamad Medical Corporation, Doha, Qatar."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmad","family":"Al-Sabbagh","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine and Pathology, National Center for Cancer Care and Research, Hamad Medical Corporation, Doha, Qatar."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruba Y.","family":"Taha","sequence":"additional","affiliation":[{"name":"Department of Hematology and Medical Oncology, National Center for Cancer Care and Research, Hamad Medical Corporation, Doha, Qatar."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dina S.","family":"Soliman","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine and Pathology, National Center for Cancer Care and Research, Hamad Medical Corporation, Doha, Qatar."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2015,12,2]]},"reference":[{"key":"bibr1-CMO.S35120","volume-title":"Hematopathology.","author":"Jaffe 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