{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T10:36:52Z","timestamp":1777891012155,"version":"3.51.4"},"reference-count":24,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2008,1,1]],"date-time":"2008-01-01T00:00:00Z","timestamp":1199145600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical medicine. Oncology"],"published-print":{"date-parts":[[2008,1]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Melanoma and Merkel cell carcinoma (MCC) are both aggressive skin malignancies associated with immunosuppression and possible UV exposure. Both tumors get similar surgical treatment; however, MCC is a relatively rare tumor in which less is known about prognosis and clinical behavior.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The California Cancer Registry (CCR), a population-based registry, was reviewed from the years 1988-2003. Merkel cell carcinoma and melanoma were compared with relation to gender, age, ethnicity, disease stage, site, and survival.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 113,187 cases of melanoma and 1,878 cases of MCC were identified in the CCR. Though both cancers are more common in men than in women, MCC had a higher incidence in men than melanoma (63% vs 57% p &lt; 0.005). MCC occurs in the more elderly, with 73.6% of cases occurring in people over 70 years. In contrast, 69% of melanoma cases occurred in people younger than 70 years (p &lt; 0.005). MCC shows a predilection for the head and neck compared to melanoma (47% vs 25.8%) Additionally, melanoma occurs more frequently on the trunk than MCC (30% vs 8.7%). Finally, the 10-year cumulative survival is lower for MCC than for melanoma (17.7% vs 61.3%, p &lt; 0.005).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Many clinicians assume MCC and melanoma behave similarly. However, MCC occurs in an older population, more frequently on the head and neck, in a higher percentage of men. Additionally, MCC has a higher rate of regional metastasis and thus may have more of a benefit from regional staging procedures. Overall, MCC has a worse prognosis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4137\/cmo.s423","type":"journal-article","created":{"date-parts":[[2017,9,14]],"date-time":"2017-09-14T07:21:30Z","timestamp":1505373690000},"source":"Crossref","is-referenced-by-count":9,"title":["A Comparison of Merkel Cell Carcinoma and Melanoma: Results from the California Cancer Registry"],"prefix":"10.4137","volume":"2","author":[{"given":"Julia","family":"Grabowski","sequence":"first","affiliation":[{"name":"Department of Family and Preventive Medicine, University of California at San Diego School of Medicine, La Jolla, CA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sidney L","family":"Saltzstein","sequence":"additional","affiliation":[{"name":"Department of Family and Preventive Medicine, University of California at San Diego School of Medicine, La Jolla, CA."},{"name":"Department of Pathology, University of California at San Diego School of Medicine, La Jolla, CA."},{"name":"Department of Surgery, University of California at San Diego School of Medicine, La Jolla, CA."},{"name":"Rebecca and John Moores UCSD Cancer Center, University of California at San Diego School of Medicine, La Jolla, CA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Georgia Robins","family":"Sadler","sequence":"additional","affiliation":[{"name":"Department of Surgery, University of California at San Diego School of Medicine, La Jolla, CA."},{"name":"Rebecca and John Moores UCSD Cancer Center, University of California at San Diego School of Medicine, La Jolla, CA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zunera","family":"Tahir","sequence":"additional","affiliation":[{"name":"Rebecca and John Moores UCSD Cancer Center, University of California at San Diego School of Medicine, La Jolla, CA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah","family":"Blair","sequence":"additional","affiliation":[{"name":"Department of Surgery, University of California at San Diego School of Medicine, La Jolla, CA."},{"name":"Rebecca and John Moores UCSD Cancer Center, University of California at San Diego School of Medicine, La Jolla, CA."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2008,4,1]]},"reference":[{"key":"bibr1-CMO.S423","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2000.106505"},{"key":"bibr2-CMO.S423","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.02.329"},{"key":"bibr3-CMO.S423","unstructured":"AriasZ. 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