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This compound with amphoteric properties was designed in the former Germany Democratic Republic in 1960s and re-discovered in 1990s with multiple successive well-designed studies. Bendamustine possesses a unique mechanism of action with potential antimetabolite properties, and only partial cross-resistance with other alkylators. Used in combination with rituximab in vitro, bendamustine shows synergistic effects against various leukemia and lymphoma cell lines. In clinical studies, bendamustine plus rituximab is highly effective in patients with relapsed-refractory indolent lymphoma, inducing remissions in 90% or more and a median progression-free survival of 23\u201324 months. The optimal dosing and schedule of bendamustine administration is largely undecided and varies among studies. Results of ongoing trials and dose-finding studies will help to further help ascertain the optimal place of bendamustine in the management of indolent NHL.<\/jats:p>","DOI":"10.4137\/cmo.s6085","type":"journal-article","created":{"date-parts":[[2011,5,18]],"date-time":"2011-05-18T20:37:28Z","timestamp":1305751048000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":20,"title":["Bendamustine: Safety and Efficacy in the Management of Indolent Non-Hodgkins Lymphoma"],"prefix":"10.4137","volume":"5","author":[{"given":"Nishant","family":"Tageja","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Wayne State University, Detroit Medical Center, Detroit, MI, USA. 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