{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T10:37:12Z","timestamp":1777891032903,"version":"3.51.4"},"reference-count":58,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Med Insights Oncol"],"published-print":{"date-parts":[[2010,1]]},"abstract":"<jats:p>\n                    Interferon alpha (IFN-\u03b1) has been used as a maintenance therapy after autologous stem cell transplantation (ASCT) for multiple myeloma (MM) patients. In this study, we combined GM-CSF with IFN-\u03b1 in order to improve IFN tolerance in post-ASCT myeloma patients. Primary aims were to evaluate myelotoxicity and effectiveness of this maintenance therapy. The treatment included 4 \u00d7 10\n                    <jats:sup>6<\/jats:sup>\n                    units of IFN-\u03b1 and 125 \u03bcg\/m\n                    <jats:sup>2<\/jats:sup>\n                    of GM-CSF given three times a week for twelve months. Twenty seven patients were enrolled within 120 days after ASCT. One patient discontinued treatment due to thrombocytopenia and seven others were taken off study due to fu-like symptoms and\/or increase in liver enzymes. With a median follow-up of 45.5 months, the median overall survival was not reached while the median progression-free survival was 28 months. Eleven patients (42%) have remained in very good partial remission or complete remission since ASCT. In conclusion, our results demonstrate that maintenance with GM-CSF and IFN-\u03b1 is safe and effective.\n                  <\/jats:p>","DOI":"10.4137\/cmo.s6161","type":"journal-article","created":{"date-parts":[[2010,11,16]],"date-time":"2010-11-16T21:45:32Z","timestamp":1289943932000},"source":"Crossref","is-referenced-by-count":5,"title":["Combination of IFN-\u03b1\/Gm-CSF as a Maintenance Therapy for Multiple Myeloma Patients after Autologous Stem Cell Transplantation (ASCT): A Prospective Phase II Study"],"prefix":"10.4137","volume":"4","author":[{"given":"Donya","family":"Salmasinia","sequence":"first","affiliation":[{"name":"Department of Medicine, University of Florida, Gainesville, Florida, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Myron","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Health Policy Research, University of Florida, Gainesville, Florida, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John R.","family":"Wingard","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Florida, Gainesville, Florida, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Hou","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Health Policy Research, University of Florida, Gainesville, Florida, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan S.","family":"Moreb","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Florida, Gainesville, Florida, 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