{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T10:38:18Z","timestamp":1777891098257,"version":"3.51.4"},"reference-count":68,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Clin Med\ufffdInsights\ufffdReprod\ufffdHealth"],"published-print":{"date-parts":[[2014,1]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To determine the prevalence of chromosomal abnormalities and microdeletions on Y chromosome in infertile patients with oligozoospermia or azoospermia in Mato Grosso state, Brazil.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This cross-sectional study enrolled 94 men from infertile couples. Karyotype analysis was performed by lymphocyte culture technique. DNA from each sample was extracted using non-enzymatic method. Microdeletions were investigated by polymerase chain reaction (PCR).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>With the use of cytogenetic analysis, five patients (5.3%) had abnormal karyotype, one azoospermic patient (1.1%) had karyotype 46,XY,t(7;1) (qter-p35), one (1.1%) with mild oligozoospermia had karyotype 46, XY, delY(q), and two other azoospermic patients had karyotype 47,XXY, consistent with Klinefelter syndrome (KS). One of them (1.1%) with severe oligozoospermia had karyotype 46,XY,8p+. Microdeletion on Y chromosome was found in the azoospermia factor c (AZFc) region in only one azoospermic patient (1.1%).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The prevalence of genetic abnormalities in oligo\/azoospermic Brazilian men from infertile couple was 5.3%, and microdeletion on Y chromosome was not a common finding in this population (1.1%).<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4137\/cmrh.s15475","type":"journal-article","created":{"date-parts":[[2014,8,11]],"date-time":"2014-08-11T19:42:30Z","timestamp":1407786150000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["The Low Prevalence of Y Chromosomal Microdeletions is Observed in the Oligozoospermic Men in the Area of Mato Grosso State and Amazonian Region of Brazilian Patients"],"prefix":"10.4137","volume":"8","author":[{"given":"Gleice Cristina dos Santos","family":"Godoy","sequence":"first","affiliation":[{"name":"Department of Basic Sciences, Medical School, UFMT, Cuiab\u00e1, MT, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bianca Borsatto","family":"Galera","sequence":"additional","affiliation":[{"name":"Department of Basic Sciences, Medical School, UFMT, Cuiab\u00e1, MT, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudin\u00e9ia","family":"Araujo","sequence":"additional","affiliation":[{"name":"Faculty of Biology, Federal University of Mato Grosso, UFMT, Cuiab\u00e1, MT, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacklyne Silva","family":"Barbosa","sequence":"additional","affiliation":[{"name":"Tropical Institute of Reproductive Medicine and Menopause, Cuiab\u00e1, MT, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Max Fernando","family":"De Pinho","sequence":"additional","affiliation":[{"name":"Faculty of Biology, Federal University of Mato Grosso, UFMT, Cuiab\u00e1, MT, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcial Francis","family":"Galera","sequence":"additional","affiliation":[{"name":"Department of Basic Sciences, Medical School, UFMT, Cuiab\u00e1, MT, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sebasti\u00e3o Freitas","family":"de Medeiros","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics, Faculty of Medicine, UFMT, Cuiab\u00e1, MT, Brazil."},{"name":"Tropical Institute of Reproductive Medicine and Menopause, Cuiab\u00e1, MT, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2014,8,11]]},"reference":[{"key":"bibr1-CMRH.S15475","volume-title":"Infertility: a tabulation of available data on prevalence of primary and secondary 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