{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T10:38:44Z","timestamp":1777891124270,"version":"3.51.4"},"reference-count":75,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Int J\ufffdTryptophan\ufffdRes"],"published-print":{"date-parts":[[2012,1]]},"abstract":"<jats:p>\n                    Last century there was a short burst of interest in the tryptophan related disorders of pellagra and related abnormalities that are usually presented in infancy.\n                    <jats:sup>1 , 2<\/jats:sup>\n                    Nutritional physiologists recognized that a severe human dietary deficiency of either tryptophan or the B group vitamins could result in central nervous system (CNS) sequelae such as ataxia, cognitive dysfunction and dysphoria, accompanied by skin hyperpigmentation.\n                    <jats:sup>3 , 4<\/jats:sup>\n                    The current paper will focus on the emerging role of tryptophan in chronic fatigue syndrome (CFS) and fibromyalgia (FM).\n                  <\/jats:p>","DOI":"10.4137\/ijtr.s10085","type":"journal-article","created":{"date-parts":[[2012,9,17]],"date-time":"2012-09-17T16:57:39Z","timestamp":1347901059000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":21,"title":["A Brief Historic Overview of Clinical Disorders Associated with Tryptophan:           The Relevance to Chronic Fatigue Syndrome (CFS) and Fibromyalgia (FM)."],"prefix":"10.4137","volume":"5","author":[{"given":"Adele","family":"Blankfield","sequence":"first","affiliation":[{"name":"Kew, Australia."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2012,9,17]]},"reference":[{"key":"bibr1-IJTR.S10085","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.25.1.17"},{"issue":"237","key":"bibr2-IJTR.S10085","first-page":"5","volume":"48","author":"Lehman J.","year":"1972","journal-title":"Acta Psychiatr Scand."},{"key":"bibr3-IJTR.S10085","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1992.tb17121.x"},{"key":"bibr4-IJTR.S10085","volume-title":"Organic Psychiatry.","author":"Lisham W.A.","year":"1987","edition":"2"},{"key":"bibr5-IJTR.S10085","volume-title":"Biochemical and Health Implications.","author":"Sidransky H.","year":"2001"},{"key":"bibr6-IJTR.S10085","doi-asserted-by":"publisher","DOI":"10.1126\/science.173.3992.149"},{"key":"bibr7-IJTR.S10085","doi-asserted-by":"publisher","DOI":"10.4137\/IJTR.S2129"},{"key":"bibr8-IJTR.S10085","doi-asserted-by":"publisher","DOI":"10.1007\/s002130000655"},{"key":"bibr9-IJTR.S10085","volume-title":"Harrison's Principles of Internal Medicine.","author":"Wilson J.D.","year":"1983"},{"key":"bibr10-IJTR.S10085","doi-asserted-by":"publisher","DOI":"10.4137\/IJTR.S2097"},{"key":"bibr11-IJTR.S10085","doi-asserted-by":"publisher","DOI":"10.1017\/S1462399406000068"},{"key":"bibr12-IJTR.S10085","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2005.06.013"},{"key":"bibr13-IJTR.S10085","doi-asserted-by":"publisher","DOI":"10.2174\/138920007780362536"},{"key":"bibr14-IJTR.S10085","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2010.12.006"},{"key":"bibr15-IJTR.S10085","doi-asserted-by":"publisher","DOI":"10.1096\/fasebj.5.11.1907934"},{"key":"bibr16-IJTR.S10085","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2004.10.031"},{"key":"bibr17-IJTR.S10085","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.65.3.291"},{"key":"bibr18-IJTR.S10085","volume-title":"Sleisenger and Fordtran's gastrointestinal and liver disease: Pathophysiology, Diagnosis, Management.","author":"Hogenauer C.","year":"2006","edition":"8"},{"key":"bibr19-IJTR.S10085","doi-asserted-by":"publisher","DOI":"10.1080\/003655201300051135"},{"key":"bibr20-IJTR.S10085","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM196004142621504"},{"key":"bibr21-IJTR.S10085","first-page":"908","volume":"58","author":"Scriver C.R.","year":"1961","journal-title":"J Lab Clin Med."},{"key":"bibr22-IJTR.S10085","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.2.5861.265"},{"key":"bibr23-IJTR.S10085","volume-title":"Introduction to nutrition and metabolism.","author":"Bender Da","year":"2008","edition":"4"},{"key":"bibr24-IJTR.S10085","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(97)11050-9"},{"issue":"8","key":"bibr25-IJTR.S10085","first-page":"2944","volume":"85","author":"Ekwall O.","year":"2000","journal-title":"J Clin Endocrinol Metab."},{"key":"bibr26-IJTR.S10085","doi-asserted-by":"publisher","DOI":"10.2174\/1875397301004010019"},{"key":"bibr27-IJTR.S10085","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2011.06.024"},{"key":"bibr28-IJTR.S10085","doi-asserted-by":"publisher","DOI":"10.1016\/0009-8981(74)90226-5"},{"key":"bibr29-IJTR.S10085","doi-asserted-by":"publisher","DOI":"10.1136\/adc.45.242.485"},{"issue":"5","key":"bibr30-IJTR.S10085","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1542\/peds.76.5.787","volume":"76","author":"Salih M.A.","year":"1985","journal-title":"Pediatrics."},{"key":"bibr31-IJTR.S10085","doi-asserted-by":"publisher","DOI":"10.2217\/14796708.1.5.651"},{"key":"bibr32-IJTR.S10085","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/137.6.1568S"},{"key":"bibr33-IJTR.S10085","doi-asserted-by":"publisher","DOI":"10.1159\/000271918"},{"key":"bibr34-IJTR.S10085","doi-asserted-by":"publisher","DOI":"10.1136\/adc.52.1.38"},{"key":"bibr35-IJTR.S10085","doi-asserted-by":"publisher","DOI":"10.1038\/ng1406"},{"key":"bibr36-IJTR.S10085","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2230.1994.tb02694.x"},{"key":"bibr37-IJTR.S10085","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.pa.15.040175.000445"},{"issue":"8","key":"bibr38-IJTR.S10085","first-page":"296","volume":"53","author":"Fuchs D.","year":"1992","journal-title":"J Clin Psychiatry."},{"issue":"9","key":"bibr39-IJTR.S10085","doi-asserted-by":"crossref","first-page":"S222","DOI":"10.1002\/art.1780360922","volume":"36","author":"Russell I.J.","year":"1993","journal-title":"Arthritis Rheum."},{"key":"bibr40-IJTR.S10085","doi-asserted-by":"publisher","DOI":"10.4137\/IJTR.S7898"},{"key":"bibr41-IJTR.S10085","volume-title":"Conjectures and Refutations. The growth of scientific knowledge.","author":"Popper Karl R.","year":"1972"},{"issue":"2","key":"bibr42-IJTR.S10085","first-page":"93","volume":"5","author":"Werbach M.R.","year":"2000","journal-title":"Altern Med Rev."},{"key":"bibr43-IJTR.S10085","author":"Werbach M.R.","year":"2001","journal-title":"Townsend letter for doctors and patients."},{"key":"bibr44-IJTR.S10085","doi-asserted-by":"publisher","DOI":"10.1099\/0022-1317-82-12-3011"},{"key":"bibr45-IJTR.S10085","doi-asserted-by":"publisher","DOI":"10.1016\/j.clineuro.2010.12.002"},{"key":"bibr46-IJTR.S10085","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.156.4.534"},{"key":"bibr47-IJTR.S10085","volume-title":"The Doctors Guide to Chronic Fatigue Syndrome.","author":"Bell David S.","year":"1995"},{"key":"bibr48-IJTR.S10085","doi-asserted-by":"publisher","DOI":"10.1300\/J094v11n04_03"},{"issue":"1","key":"bibr49-IJTR.S10085","first-page":"7","volume":"11","author":"Carruthers B.M.","year":"2003","journal-title":"JCFS."},{"key":"bibr50-IJTR.S10085","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(200109)44:9<2125::AID-ART365>3.0.CO;2-1"},{"key":"bibr51-IJTR.S10085","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2474-10-162"},{"key":"bibr52-IJTR.S10085","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2010.06.005"},{"key":"bibr53-IJTR.S10085","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2012.00090"},{"key":"bibr54-IJTR.S10085","doi-asserted-by":"publisher","DOI":"10.1097\/00006842-197507000-00008"},{"issue":"1","key":"bibr55-IJTR.S10085","first-page":"90","volume":"19","author":"Yunus M.B.","year":"1992","journal-title":"J Rheumatol."},{"key":"bibr56-IJTR.S10085","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4615-0135-0_30"},{"key":"bibr57-IJTR.S10085","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinbiochem.2009.02.025"},{"key":"bibr58-IJTR.S10085","doi-asserted-by":"publisher","DOI":"10.1016\/j.cccn.2005.05.023"},{"key":"bibr59-IJTR.S10085","doi-asserted-by":"publisher","DOI":"10.3181\/0702-RM-44"},{"key":"bibr60-IJTR.S10085","doi-asserted-by":"publisher","DOI":"10.1016\/j.tibs.2006.11.006"},{"key":"bibr61-IJTR.S10085","doi-asserted-by":"publisher","DOI":"10.1086\/367544"},{"key":"bibr62-IJTR.S10085","doi-asserted-by":"publisher","DOI":"10.3109\/03009749709105320"},{"key":"bibr63-IJTR.S10085","doi-asserted-by":"publisher","DOI":"10.1038\/ejcn.2009.149"},{"key":"bibr64-IJTR.S10085","doi-asserted-by":"publisher","DOI":"10.1089\/acm.2008.0410"},{"key":"bibr65-IJTR.S10085","volume-title":"Cellular Hypoxia and Neuro-immune Fatigue.","author":"Bell David S.","year":"2007"},{"key":"bibr66-IJTR.S10085","doi-asserted-by":"publisher","DOI":"10.1186\/1479-5876-9-81"},{"key":"bibr67-IJTR.S10085","doi-asserted-by":"publisher","DOI":"10.5694\/j.1326-5377.1989.tb139594.x"},{"key":"bibr68-IJTR.S10085","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-6749(03)02014-1"},{"key":"bibr69-IJTR.S10085","doi-asserted-by":"publisher","DOI":"10.2165\/00002018-199410020-00003"},{"key":"bibr70-IJTR.S10085","doi-asserted-by":"publisher","DOI":"10.1099\/vir.0.017590-0"},{"key":"bibr71-IJTR.S10085","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2011.06.016"},{"issue":"11","key":"bibr72-IJTR.S10085","first-page":"4717","volume":"29","author":"Meeus M.","year":"2009","journal-title":"Anticancer Res."},{"key":"bibr73-IJTR.S10085","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4615-4709-9_64"},{"key":"bibr74-IJTR.S10085","doi-asserted-by":"publisher","DOI":"10.1016\/j.mehy.2009.04.043"},{"key":"bibr75-IJTR.S10085","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.149.1.23"}],"container-title":["International Journal of Tryptophan Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.4137\/IJTR.S10085","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.4137\/IJTR.S10085","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.4137\/IJTR.S10085","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T05:54:48Z","timestamp":1777614888000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.4137\/IJTR.S10085"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,1]]},"references-count":75,"alternative-id":["10.4137\/IJTR.S10085"],"URL":"https:\/\/doi.org\/10.4137\/ijtr.s10085","relation":{},"ISSN":["1178-6469","1178-6469"],"issn-type":[{"value":"1178-6469","type":"print"},{"value":"1178-6469","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,1]]},"article-number":"IJTR.S10085"}}