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The investigative approaches in this field include manipulations of tryptophan availability as well as genetic association and functional brain imaging studies. In this review we examine the principle findings of these studies and propose further research directions.<\/jats:p>","DOI":"10.4137\/ijtr.s929","type":"journal-article","created":{"date-parts":[[2017,11,15]],"date-time":"2017-11-15T09:36:19Z","timestamp":1510738579000},"source":"Crossref","is-referenced-by-count":5,"title":["Tryptophan Research in Panic Disorder"],"prefix":"10.4137","volume":"1","author":[{"given":"Eduard","family":"Maron","sequence":"first","affiliation":[{"name":"Research Department of Mental Health, The North Estonian Regional Hospital, Psychiatry Clinic, Tallinn, Estonia."},{"name":"Department of Psychiatry, University of Tartu, Tartu, Estonia."},{"name":"Estonian Genome Project, University of Tartu, Estonia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jakov","family":"Shlik","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, University of Ottawa, Ottawa, Ontario, Canada."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David J.","family":"Nutt","sequence":"additional","affiliation":[{"name":"Department of Community Based Medicine, Psychopharmacology Unit, University of Bristol, U.K."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2008,8,14]]},"reference":[{"key":"bibr1-IJTR.S929","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2004.07.006"},{"key":"bibr2-IJTR.S929","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1994.03950040053007"},{"key":"bibr3-IJTR.S929","doi-asserted-by":"publisher","DOI":"10.1177\/026988110201600116"},{"key":"bibr4-IJTR.S929","doi-asserted-by":"publisher","DOI":"10.1080\/j.1440-1614.2005.01628.x"},{"key":"bibr5-IJTR.S929","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuint.2007.08.021"},{"key":"bibr6-IJTR.S929","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2005.08.023"},{"key":"bibr7-IJTR.S929","first-page":"271","volume":"3","author":"Birdsall T.","year":"1998","journal-title":"Altern. 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