{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T21:12:51Z","timestamp":1783026771159,"version":"3.54.6"},"reference-count":78,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Cent Nerv Syst Dis"],"published-print":{"date-parts":[[2014,1]]},"abstract":"<jats:p>Essential tremor (ET) is the most common pathological tremor characterized by upper limb action\u2014postural tremor (PT)\/kinetic tremor (KT). There are no specific neuropathological or biochemical abnormalities in ET. The disability is consequent to amplitude of KT, which may remain mild without handicap or may become disabling. The most effective drugs for sustained tremor control are propranolol and primidone. Symptomatic drug treatment must be individualized depending on the circumstances that provoke the tremor-related disability. Broad guidelines for treatment are discussed in this review. Patients may be treated intermittently only on stressful occasions with propranolol, clonazepam, or primidone monotherapy, or an alcoholic drink. Those with persistently disabling tremor need continued treatment.<\/jats:p>","DOI":"10.4137\/jcnsd.s13570","type":"journal-article","created":{"date-parts":[[2014,4,21]],"date-time":"2014-04-21T16:43:20Z","timestamp":1398098600000},"page":"JCNSD.S13570","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":24,"title":["Medical Treatment of Essential Tremor"],"prefix":"10.4137","volume":"6","author":[{"given":"Ali H.","family":"Rajput","sequence":"first","affiliation":[{"name":"University of Saskatchewan, Canada."},{"name":"Saskatoon Health Region, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alex","family":"Rajput","sequence":"additional","affiliation":[{"name":"University of Saskatchewan, Canada."},{"name":"Saskatoon Health Region, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2014,4,21]]},"reference":[{"key":"bibr1-JCNSD.S13570","doi-asserted-by":"publisher","DOI":"10.1002\/mds.870131303"},{"key":"bibr3-JCNSD.S13570","doi-asserted-by":"publisher","DOI":"10.1016\/j.ncl.2009.04.003"},{"key":"bibr4-JCNSD.S13570","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/72.2.113"},{"issue":"4","key":"bibr5-JCNSD.S13570","first-page":"S8","volume":"54","author":"Findley L.J.","year":"2000","journal-title":"Neurology."},{"key":"bibr7-JCNSD.S13570","first-page":"151","volume":"55","author":"Rajput A.H.","year":"1976","journal-title":"Can J Neurol Sci."},{"key":"bibr8-JCNSD.S13570","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.36.7.1001"},{"key":"bibr9-JCNSD.S13570","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.41.12.1982"},{"key":"bibr10-JCNSD.S13570","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2011.03.012"},{"key":"bibr11-JCNSD.S13570","doi-asserted-by":"publisher","DOI":"10.1097\/00002826-198309000-00002"},{"key":"bibr12-JCNSD.S13570","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000115145.18830.1A"},{"key":"bibr13-JCNSD.S13570","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(10)70322-7"},{"issue":"11","key":"bibr14-JCNSD.S13570","first-page":"S2","volume":"54","author":"Elble R.J.","year":"2000","journal-title":"Neurology."},{"issue":"4","key":"bibr15-JCNSD.S13570","first-page":"S7","volume":"54","author":"Bain P.","year":"2000","journal-title":"Neurology."},{"key":"bibr16-JCNSD.S13570","doi-asserted-by":"publisher","DOI":"10.1002\/mds.20487"},{"key":"bibr17-JCNSD.S13570","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.50.5.561"},{"key":"bibr18-JCNSD.S13570","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.55.10.1547"},{"key":"bibr19-JCNSD.S13570","doi-asserted-by":"publisher","DOI":"10.1017\/S031716710004765X"},{"key":"bibr20-JCNSD.S13570","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2010.215681"},{"issue":"5","key":"bibr21-JCNSD.S13570","first-page":"1018","volume":"21","author":"Rajput A.H.","year":"1973","journal-title":"Clin Res."},{"key":"bibr22-JCNSD.S13570","doi-asserted-by":"publisher","DOI":"10.1017\/S0317167100019958"},{"key":"bibr23-JCNSD.S13570","doi-asserted-by":"publisher","DOI":"10.1002\/mds.23811"},{"key":"bibr24-JCNSD.S13570","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.47.5.466"},{"key":"bibr25-JCNSD.S13570","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.63.8.1100"},{"key":"bibr26-JCNSD.S13570","doi-asserted-by":"publisher","DOI":"10.1002\/mds.22108"},{"key":"bibr27-JCNSD.S13570","doi-asserted-by":"publisher","DOI":"10.1007\/s00702-005-0354-9"},{"key":"bibr28-JCNSD.S13570","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainresbull.2005.11.010"},{"key":"bibr29-JCNSD.S13570","doi-asserted-by":"publisher","DOI":"10.1002\/mds.870040210"},{"key":"bibr30-JCNSD.S13570","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000335270.73346.60"},{"key":"bibr31-JCNSD.S13570","doi-asserted-by":"publisher","DOI":"10.1002\/mds.23328"},{"issue":"4","key":"bibr32-JCNSD.S13570","doi-asserted-by":"crossref","first-page":"S14","DOI":"10.1212\/WNL.54.4.14A","volume":"54","author":"Deuschl G.","year":"2000","journal-title":"Neurology."},{"key":"bibr33-JCNSD.S13570","doi-asserted-by":"publisher","DOI":"10.1002\/mds.10553"},{"key":"bibr34-JCNSD.S13570","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410160412"},{"key":"bibr35-JCNSD.S13570","doi-asserted-by":"publisher","DOI":"10.1002\/mds.20894"},{"key":"bibr36-JCNSD.S13570","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000225073.48743.9e"},{"key":"bibr37-JCNSD.S13570","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-012-6628-x"},{"key":"bibr38-JCNSD.S13570","doi-asserted-by":"publisher","DOI":"10.1517\/14740338.4.5.899"},{"key":"bibr39-JCNSD.S13570","doi-asserted-by":"publisher","DOI":"10.1002\/mds.22755"},{"key":"bibr40-JCNSD.S13570","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.32.6.509"},{"key":"bibr41-JCNSD.S13570","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.41.9.1422"},{"issue":"7","key":"bibr42-JCNSD.S13570","first-page":"A537","volume":"62","author":"Ross G.W.","year":"2004","journal-title":"Neurology."},{"key":"bibr43-JCNSD.S13570","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000310425.76205.02"},{"key":"bibr44-JCNSD.S13570","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awm266"},{"key":"bibr45-JCNSD.S13570","doi-asserted-by":"publisher","DOI":"10.1001\/archneurol.2007.8"},{"key":"bibr46-JCNSD.S13570","doi-asserted-by":"publisher","DOI":"10.1001\/archneurol.2009.217"},{"key":"bibr47-JCNSD.S13570","doi-asserted-by":"publisher","DOI":"10.1002\/mds.22971"},{"key":"bibr48-JCNSD.S13570","doi-asserted-by":"publisher","DOI":"10.2217\/nmt.12.23"},{"key":"bibr49-JCNSD.S13570","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2011.05.008"},{"key":"bibr50-JCNSD.S13570","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2012.01.013"},{"key":"bibr51-JCNSD.S13570","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2012.11.019"},{"key":"bibr52-JCNSD.S13570","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awr301"},{"key":"bibr53-JCNSD.S13570","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.109.074120"},{"issue":"3","key":"bibr54-JCNSD.S13570","first-page":"A302","volume":"56","author":"Rajput A.H.","year":"2001","journal-title":"Neurology."},{"key":"bibr55-JCNSD.S13570","doi-asserted-by":"publisher","DOI":"10.1002\/mds.23289"},{"key":"bibr56-JCNSD.S13570","doi-asserted-by":"publisher","DOI":"10.1002\/mds.22633"},{"key":"bibr57-JCNSD.S13570","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0404.1982.tb03129.x"},{"key":"bibr58-JCNSD.S13570","doi-asserted-by":"publisher","DOI":"10.1159\/000110376"},{"key":"bibr59-JCNSD.S13570","doi-asserted-by":"publisher","DOI":"10.1159\/000109805"},{"key":"bibr60-JCNSD.S13570","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2008.03.009"},{"key":"bibr61-JCNSD.S13570","doi-asserted-by":"publisher","DOI":"10.1002\/mds.25355"},{"key":"bibr62-JCNSD.S13570","doi-asserted-by":"publisher","DOI":"10.1002\/mds.870130508"},{"key":"bibr63-JCNSD.S13570","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.34.2.221"},{"key":"bibr64-JCNSD.S13570","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.25.3.259"},{"key":"bibr65-JCNSD.S13570","doi-asserted-by":"publisher","DOI":"10.1002\/mds.23846"},{"key":"bibr66-JCNSD.S13570","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0404.1983.tb05345.x"},{"key":"bibr67-JCNSD.S13570","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.33.8.1074"},{"key":"bibr68-JCNSD.S13570","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000163769.28552.CD"},{"key":"bibr69-JCNSD.S13570","first-page":"1117","volume":"1","author":"Rajput A.H.","year":"1972","journal-title":"Lancet."},{"key":"bibr70-JCNSD.S13570","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197405022901802"},{"key":"bibr71-JCNSD.S13570","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(05)00991-9"},{"key":"bibr72-JCNSD.S13570","doi-asserted-by":"publisher","DOI":"10.1007\/s11940-006-0016-8"},{"key":"bibr73-JCNSD.S13570","doi-asserted-by":"publisher","DOI":"10.3949\/ccjm.78a.10178"},{"key":"bibr74-JCNSD.S13570","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.45.8.1523"},{"key":"bibr75-JCNSD.S13570","doi-asserted-by":"publisher","DOI":"10.1002\/1531-8257(199905)14:3<468::AID-MDS1013>3.0.CO;2-M"},{"key":"bibr76-JCNSD.S13570","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0404.1986.tb03279.x"},{"key":"bibr77-JCNSD.S13570","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e318236f0fd"},{"key":"bibr78-JCNSD.S13570","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.56.11.1523"},{"key":"bibr79-JCNSD.S13570","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2010.08.009"},{"key":"bibr80-JCNSD.S13570","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1331.2009.02926.x"}],"container-title":["Journal of Central Nervous System Disease"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/journals.sagepub.com\/doi\/pdf\/10.4137\/JCNSD.S13570","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/journals.sagepub.com\/doi\/full-xml\/10.4137\/JCNSD.S13570","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/journals.sagepub.com\/doi\/pdf\/10.4137\/JCNSD.S13570","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T16:00:10Z","timestamp":1777392010000},"score":1,"resource":{"primary":{"URL":"http:\/\/journals.sagepub.com\/doi\/10.4137\/JCNSD.S13570"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,1]]},"references-count":78,"alternative-id":["10.4137\/JCNSD.S13570"],"URL":"https:\/\/doi.org\/10.4137\/jcnsd.s13570","relation":{},"ISSN":["1179-5735","1179-5735"],"issn-type":[{"value":"1179-5735","type":"print"},{"value":"1179-5735","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,1]]}}}