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During the phase III clinical trials, it was shown that Nat reduces disease activity and prevents disability progression. In addition, several smaller studies indicate a positive influence of Nat on cognition, depression, fatigue, and quality of life (Qol). Therapeutic efficacy has to be weighed against the risk of developing potentially fatal progressive multifocal leukoencephalopathy (PML), an opportunistic infection by JC-virus (JCV) with an incidence of 3.4\/1000 (95% CI 3.08\u20133.74) in Nat treated MS patients. In this review article, we will review data on the presumed mechanism of Nat action, clinical and paraclinical efficacy parameters, and adverse drug reactions with a special focus on PML.<\/jats:p>","DOI":"10.4137\/jcnsd.s14049","type":"journal-article","created":{"date-parts":[[2014,4,28]],"date-time":"2014-04-28T16:39:46Z","timestamp":1398703186000},"page":"JCNSD.S14049","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":51,"title":["Efficacy and Side Effects of Natalizumab Therapy in Patients with Multiple Sclerosis"],"prefix":"10.4137","volume":"6","author":[{"given":"Robert","family":"Hoepner","sequence":"first","affiliation":[{"name":"Department of Neurology, St. Josef-Hospital, Ruhr-University Bochum, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon","family":"Faissner","sequence":"additional","affiliation":[{"name":"Department of Neurology, St. Josef-Hospital, Ruhr-University 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