{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T02:40:23Z","timestamp":1777516823149,"version":"3.51.4"},"reference-count":107,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Cent Nerv Syst Dis"],"published-print":{"date-parts":[[2016,1]]},"abstract":"<jats:p>Recent advances in neuroscience challenge the old dogma that neurogenesis occurs only during embryonic development. Mounting evidence suggests that functional neurogenesis occurs throughout adulthood. This review article discusses molecular factors that affect adult neurogenesis, including morphogens, growth factors, neurotransmitters, transcription factors, and epigenetic factors. Furthermore, we summarize and compare current evidence of associations between adult neurogenesis and human brain diseases such as Alzheimer's disease, Parkinson's disease, Huntington's disease, and brain tumors.<\/jats:p>","DOI":"10.4137\/jcnsd.s32204","type":"journal-article","created":{"date-parts":[[2016,6,20]],"date-time":"2016-06-20T17:16:52Z","timestamp":1466443012000},"page":"JCNSD.S32204","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":45,"title":["Molecular Mechanism of Adult Neurogenesis and its Association with Human Brain Diseases"],"prefix":"10.4137","volume":"8","author":[{"given":"He","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Biology, Morosky College of Health Professions and Sciences, Gannon University, Erie, PA, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ni","family":"Song","sequence":"additional","affiliation":[{"name":"Division of Health Sciences & Workforce Technology, Lamar State College-Orange, Orange, TX, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2016,6,20]]},"reference":[{"key":"bibr1-JCNSD.S32204","doi-asserted-by":"publisher","DOI":"10.1002\/cne.901240303"},{"key":"bibr2-JCNSD.S32204","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.22-03-00629.2002"},{"key":"bibr3-JCNSD.S32204","doi-asserted-by":"publisher","DOI":"10.1002\/0470870834.ch14"},{"key":"bibr4-JCNSD.S32204","doi-asserted-by":"publisher","DOI":"10.1038\/3305"},{"key":"bibr5-JCNSD.S32204","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2014.01.044"},{"key":"bibr6-JCNSD.S32204","doi-asserted-by":"publisher","DOI":"10.1038\/4151030a"},{"key":"bibr7-JCNSD.S32204","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2013.05.002"},{"key":"bibr8-JCNSD.S32204","doi-asserted-by":"publisher","DOI":"10.1242\/dev.104596"},{"key":"bibr9-JCNSD.S32204","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00004.2014"},{"key":"bibr10-JCNSD.S32204","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-psych-010814-015006"},{"key":"bibr11-JCNSD.S32204","doi-asserted-by":"publisher","DOI":"10.1101\/gad.187336.112"},{"key":"bibr12-JCNSD.S32204","doi-asserted-by":"publisher","DOI":"10.1016\/j.jare.2013.04.005"},{"key":"bibr13-JCNSD.S32204","doi-asserted-by":"publisher","DOI":"10.1007\/s11060-009-9856-x"},{"key":"bibr14-JCNSD.S32204","doi-asserted-by":"publisher","DOI":"10.1242\/dev.01043"},{"key":"bibr15-JCNSD.S32204","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0710156104"},{"key":"bibr16-JCNSD.S32204","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2014.02.004"},{"key":"bibr17-JCNSD.S32204","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4987-09.2010"},{"key":"bibr18-JCNSD.S32204","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2011.02.031"},{"key":"bibr19-JCNSD.S32204","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2010.11.009"},{"key":"bibr20-JCNSD.S32204","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2011.01.004"},{"key":"bibr21-JCNSD.S32204","doi-asserted-by":"publisher","DOI":"10.1038\/sj.mp.4001208"},{"key":"bibr22-JCNSD.S32204","doi-asserted-by":"publisher","DOI":"10.1007\/s11481-012-9417-5"},{"key":"bibr23-JCNSD.S32204","doi-asserted-by":"publisher","DOI":"10.1007\/s00441-014-1996-4"},{"key":"bibr24-JCNSD.S32204","doi-asserted-by":"publisher","DOI":"10.1038\/nature04108"},{"key":"bibr25-JCNSD.S32204","doi-asserted-by":"publisher","DOI":"10.1002\/stem.36"},{"key":"bibr26-JCNSD.S32204","doi-asserted-by":"publisher","DOI":"10.1101\/lm.1172609"},{"key":"bibr27-JCNSD.S32204","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2010.04.016"},{"key":"bibr28-JCNSD.S32204","doi-asserted-by":"publisher","DOI":"10.1002\/stem.1688"},{"key":"bibr29-JCNSD.S32204","doi-asserted-by":"publisher","DOI":"10.1111\/j.1834-7819.1997.tb06081.x"},{"key":"bibr30-JCNSD.S32204","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2004.11.016"},{"key":"bibr31-JCNSD.S32204","doi-asserted-by":"publisher","DOI":"10.1006\/mcne.1998.0684"},{"key":"bibr32-JCNSD.S32204","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.21-17-06718.2001"},{"key":"bibr33-JCNSD.S32204","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2008.06.023"},{"key":"bibr34-JCNSD.S32204","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0803702105"},{"key":"bibr35-JCNSD.S32204","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2006.05059.x"},{"key":"bibr36-JCNSD.S32204","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-014-8717-6"},{"key":"bibr37-JCNSD.S32204","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4522(01)00378-5"},{"key":"bibr38-JCNSD.S32204","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-4547(20000201)59:3<332::AID-JNR6>3.0.CO;2-2"},{"key":"bibr39-JCNSD.S32204","doi-asserted-by":"publisher","DOI":"10.1016\/S1044-7431(03)00082-4"},{"key":"bibr40-JCNSD.S32204","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.20-08-02896.2000"},{"key":"bibr41-JCNSD.S32204","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4248-11.2012"},{"key":"bibr42-JCNSD.S32204","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1469-15.2015"},{"key":"bibr43-JCNSD.S32204","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2007.05820.x"},{"key":"bibr44-JCNSD.S32204","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbagen.2012.09.002"},{"key":"bibr45-JCNSD.S32204","doi-asserted-by":"publisher","DOI":"10.1038\/nn1522"},{"key":"bibr46-JCNSD.S32204","doi-asserted-by":"publisher","DOI":"10.1242\/dev.102608"},{"key":"bibr47-JCNSD.S32204","doi-asserted-by":"publisher","DOI":"10.1038\/nature11306"},{"key":"bibr48-JCNSD.S32204","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1999-04.2004"},{"key":"bibr49-JCNSD.S32204","doi-asserted-by":"publisher","DOI":"10.1101\/gad.479308"},{"key":"bibr50-JCNSD.S32204","doi-asserted-by":"publisher","DOI":"10.1038\/nature02211"},{"key":"bibr51-JCNSD.S32204","doi-asserted-by":"publisher","DOI":"10.1038\/ncb2001"},{"key":"bibr52-JCNSD.S32204","doi-asserted-by":"publisher","DOI":"10.1038\/nature06562"},{"key":"bibr53-JCNSD.S32204","doi-asserted-by":"publisher","DOI":"10.1038\/ng1089"},{"key":"bibr54-JCNSD.S32204","doi-asserted-by":"publisher","DOI":"10.1242\/dev.010801"},{"key":"bibr55-JCNSD.S32204","doi-asserted-by":"publisher","DOI":"10.1186\/1750-1326-9-25"},{"key":"bibr56-JCNSD.S32204","doi-asserted-by":"publisher","DOI":"10.1007\/s10571-013-9997-5"},{"key":"bibr57-JCNSD.S32204","doi-asserted-by":"publisher","DOI":"10.1016\/j.neures.2012.04.001"},{"key":"bibr58-JCNSD.S32204","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1131928100"},{"key":"bibr59-JCNSD.S32204","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2010.02.017"},{"key":"bibr60-JCNSD.S32204","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M804899200"},{"key":"bibr61-JCNSD.S32204","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2247-06.2006"},{"key":"bibr62-JCNSD.S32204","doi-asserted-by":"publisher","DOI":"10.1126\/science.1072994"},{"key":"bibr63-JCNSD.S32204","doi-asserted-by":"publisher","DOI":"10.1007\/978-94-007-5416-4_14"},{"key":"bibr64-JCNSD.S32204","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.16-06-02027.1996"},{"key":"bibr65-JCNSD.S32204","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0011866"},{"key":"bibr66-JCNSD.S32204","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2009.10.015"},{"key":"bibr67-JCNSD.S32204","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2634794100"},{"key":"bibr68-JCNSD.S32204","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2012.03.033"},{"key":"bibr69-JCNSD.S32204","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychores.2006.07.017"},{"key":"bibr70-JCNSD.S32204","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1305-10.2010"},{"key":"bibr71-JCNSD.S32204","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-2011-101881"},{"key":"bibr72-JCNSD.S32204","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2006.04.017"},{"key":"bibr73-JCNSD.S32204","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/693851"},{"key":"bibr74-JCNSD.S32204","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-015-0332-6"},{"issue":"7","key":"bibr75-JCNSD.S32204","doi-asserted-by":"crossref","first-page":"2659","DOI":"10.4049\/jimmunol.150.7.2659","volume":"150","author":"Lee S.C.","year":"1993","journal-title":"J Immunol."},{"key":"bibr76-JCNSD.S32204","doi-asserted-by":"publisher","DOI":"10.1002\/glia.22738"},{"key":"bibr77-JCNSD.S32204","doi-asserted-by":"publisher","DOI":"10.1159\/000112099"},{"key":"bibr78-JCNSD.S32204","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2004.01.007"},{"key":"bibr79-JCNSD.S32204","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2013.00229"},{"key":"bibr80-JCNSD.S32204","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1302229"},{"key":"bibr81-JCNSD.S32204","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a009399"},{"key":"bibr82-JCNSD.S32204","doi-asserted-by":"publisher","DOI":"10.2119\/2007-00100.Irvine"},{"key":"bibr83-JCNSD.S32204","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2009.08.026"},{"key":"bibr84-JCNSD.S32204","doi-asserted-by":"publisher","DOI":"10.1007\/s00702-005-0280-x"},{"key":"bibr85-JCNSD.S32204","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejrad.2013.11.024"},{"key":"bibr86-JCNSD.S32204","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0803955106"},{"key":"bibr87-JCNSD.S32204","doi-asserted-by":"publisher","DOI":"10.1038\/nn1265"},{"key":"bibr88-JCNSD.S32204","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awr256"},{"key":"bibr89-JCNSD.S32204","first-page":"321","volume":"70","author":"Berendse H.W.","year":"2006","journal-title":"J Neural Transm Suppl."},{"key":"bibr90-JCNSD.S32204","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-013-6848-8"},{"key":"bibr91-JCNSD.S32204","doi-asserted-by":"publisher","DOI":"10.1002\/mds.10713"},{"key":"bibr92-JCNSD.S32204","doi-asserted-by":"publisher","DOI":"10.1002\/mds.22009"},{"key":"bibr93-JCNSD.S32204","doi-asserted-by":"publisher","DOI":"10.1002\/mds.25087"},{"key":"bibr94-JCNSD.S32204","doi-asserted-by":"publisher","DOI":"10.1159\/000329371"},{"key":"bibr95-JCNSD.S32204","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/959154"},{"key":"bibr96-JCNSD.S32204","first-page":"90","volume":"2","author":"Doorn K.J.","year":"2014","journal-title":"Acta Neuropathol Commun."},{"key":"bibr97-JCNSD.S32204","doi-asserted-by":"publisher","DOI":"10.4238\/2013.June.13.6"},{"key":"bibr98-JCNSD.S32204","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-971176"},{"key":"bibr99-JCNSD.S32204","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1532244100"},{"key":"bibr100-JCNSD.S32204","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2004.12.051"},{"key":"bibr101-JCNSD.S32204","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchemneu.2005.05.001"},{"key":"bibr102-JCNSD.S32204","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchemneu.2006.01.005"},{"key":"bibr103-JCNSD.S32204","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra043666"},{"key":"bibr104-JCNSD.S32204","doi-asserted-by":"publisher","DOI":"10.1016\/j.jocn.2008.03.006"},{"key":"bibr105-JCNSD.S32204","doi-asserted-by":"publisher","DOI":"10.1215\/15228517-2007-023"},{"key":"bibr106-JCNSD.S32204","doi-asserted-by":"publisher","DOI":"10.1093\/neuonc\/nos268"},{"key":"bibr107-JCNSD.S32204","doi-asserted-by":"publisher","DOI":"10.2176\/nmc.oa.2013-0226"}],"container-title":["Journal of Central Nervous System Disease"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/journals.sagepub.com\/doi\/pdf\/10.4137\/JCNSD.S32204","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/journals.sagepub.com\/doi\/full-xml\/10.4137\/JCNSD.S32204","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/journals.sagepub.com\/doi\/pdf\/10.4137\/JCNSD.S32204","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T16:00:12Z","timestamp":1777392012000},"score":1,"resource":{"primary":{"URL":"http:\/\/journals.sagepub.com\/doi\/10.4137\/JCNSD.S32204"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,1]]},"references-count":107,"alternative-id":["10.4137\/JCNSD.S32204"],"URL":"https:\/\/doi.org\/10.4137\/jcnsd.s32204","relation":{},"ISSN":["1179-5735","1179-5735"],"issn-type":[{"value":"1179-5735","type":"print"},{"value":"1179-5735","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,1]]}}}