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The available data have demonstrated that vigabatrin is efficacious in the treatment of infantile spasms regardless of underlying etiology, but that it is particularly beneficial in patients with a diagnosis of tuberous sclerosis. Adrenocorticotropic hormone (ACTH), the only other medication with robust efficacy data, has been used as first line therapy for infantile spasms associated with other etiologies, and in general controls spasms sooner than vigabatrin, though relapse is common with both therapies. Vigabatrin is generally well tolerated. However, use has been associated with permanent loss of peripheral vision in some patients. In children with tuberous sclerosis, vigabatrin should be considered as initial therapy for infantile spasms. It is a viable alternative for patients with suboptimal response, contraindications or intolerance to ACTH.<\/jats:p>","DOI":"10.4137\/jcnsd.s6371","type":"journal-article","created":{"date-parts":[[2011,9,15]],"date-time":"2011-09-15T02:20:29Z","timestamp":1316053229000},"page":"JCNSD.S6371","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":9,"title":["Safety and Efficacy of Vigabatrin for the Treatment of Infantile Spasms"],"prefix":"10.4137","volume":"3","author":[{"given":"Michele A.","family":"Faulkner","sequence":"first","affiliation":[{"name":"Creighton University School of Pharmacy, Omaha, Nebraska, 68178, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Justin A.","family":"Tolman","sequence":"additional","affiliation":[{"name":"Creighton University School of Pharmacy, Omaha, Nebraska, 68178, 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