{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T03:20:33Z","timestamp":1777605633816,"version":"3.51.4"},"reference-count":60,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Exp Neurosci"],"published-print":{"date-parts":[[2015,1]]},"abstract":"<jats:p>\n                    Aripiprazole is a third-generation atypical antipsychotic and a dopamine D\n                    <jats:sub>2<\/jats:sub>\n                    receptor partial agonist. In the present study, we investigated whether a single administration of aripiprazole to mice, either as a pretreatment or as a posttreatment, would affect stereotypy induced by methamphetamine (METH). Pretreatment of male ICR mice with aripiprazole (1 or 10 mg\/kg, i.p.) attenuated the incidence of METH-induced stereotypical behavior in a dose-dependent manner. Pretreatment of mice with 1 mg\/kg aripiprazole produced an increase in the locomotor activity in mice treated with METH compared with mice treated with vehicle plus METH and with 10 mg\/kg aripiprazole plus METH. This increase in locomotion is indicative of a rightward shift in the dose-response curve for METH, consistent with a shift in the type of stereotypical behavior observed from biting to sniffing. Aripiprazole posttreatment, after METH-induced stereotypical behavior, was fully expressed and also significantly attenuated overall stereotypy in an aripiprazole dose-dependent manner. These data suggest that the antagonism of METH effects by aripiprazole should be investigated as a potential treatment for acute METH overdose.\n                  <\/jats:p>","DOI":"10.4137\/jen.s27733","type":"journal-article","created":{"date-parts":[[2015,9,10]],"date-time":"2015-09-10T17:02:14Z","timestamp":1441904534000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Pretreatment or Posttreatment with Aripiprazole Attenuates Methamphetamine-induced Stereotyped Behavior in Mice"],"prefix":"10.4137","volume":"9s1","author":[{"given":"Nobue","family":"Kitanaka","sequence":"first","affiliation":[{"name":"Department of Pharmacology, Hyogo College of Medicine, Hyogo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junichi","family":"Kitanaka","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Hyogo College of Medicine, Hyogo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F. 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