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Processes such as cholesterol biosynthesis and efflux, cholesteryl ester storage in lipid droplets, and uptake of plasma lipoproteins are tuned to the cholesterol\/PC ratio. Cholesterol-loaded macrophages in atherosclerotic lesions display increased PC biosynthesis that buffers against elevated cholesterol levels and may also facilitate cholesterol trafficking to enhance cholesterol sensing and efflux. These same mechanisms could play a generic role in homeostatic responses to acute changes in membrane free cholesterol levels. Here, I discuss the established and emerging roles of PC metabolism in promoting intracellular cholesterol trafficking and membrane lipid homeostasis. <\/jats:p>","DOI":"10.4137\/lpi.s31746","type":"journal-article","created":{"date-parts":[[2016,4,4]],"date-time":"2016-04-04T21:52:18Z","timestamp":1459806738000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":16,"title":["Phosphatidylcholine: Greasing the Cholesterol Transport Machinery"],"prefix":"10.4137","volume":"8s1","author":[{"given":"Thomas A.","family":"Lagace","sequence":"first","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, University of Ottawa Heart Institute, Ottawa, ON, 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