{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T10:40:39Z","timestamp":1777891239832,"version":"3.51.4"},"reference-count":30,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Subst\ufffdAbuse"],"published-print":{"date-parts":[[2013,1]]},"abstract":"<jats:p>Given that buprenorphine + naloxone is prescribed for opioid-dependent pregnant women, it is important to examine the extent to which it differs from buprenorphine alone, methadone, or methadone-assisted withdrawal on neonatal and maternal outcomes. Summary statistics on maternal and neonatal outcomes were collected from 7 previously published studies examining treatment for opioid-dependent pregnant women that represented a range of research methodologies. Outcomes from these studies were compared to the same outcomes for 10 women treated with the combined buprenorphine + naloxone product. There were no significant differences in maternal outcomes for buprenorphine + naloxone compared to buprenorphine, methadone, or methadone-assisted withdrawal. Preliminary findings suggest no significant adverse maternal or neonatal outcomes related to the use of buprenorphine + naloxone for the treatment of opioid dependence during pregnancy. However, further research should examine possible differences between buprenorphine + naloxone and buprenorphine alone or methadone in fetal physical development.<\/jats:p>","DOI":"10.4137\/sart.s10955","type":"journal-article","created":{"date-parts":[[2013,3,14]],"date-time":"2013-03-14T18:13:07Z","timestamp":1363284787000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":10,"title":["A Comparison of Buprenorphine + Naloxone to Buprenorphine and Methadone in the Treatment of Opioid Dependence during Pregnancy: Maternal and Neonatal Outcomes"],"prefix":"10.4137","volume":"7","author":[{"given":"Ingunn O.","family":"Lund","sequence":"first","affiliation":[{"name":"SERAF-Norwegian Centre for Addiction Research, University of Oslo, Oslo, Norway."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriele","family":"Fischer","sequence":"additional","affiliation":[{"name":"Medical University, Vienna, Department of Psychiatry and Psychotherapy, Vienna, Austria."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabrielle K.","family":"Welle-Strand","sequence":"additional","affiliation":[{"name":"SERAF-Norwegian Centre for Addiction Research, University of Oslo, Oslo, Norway."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kevin E.","family":"O'grady","sequence":"additional","affiliation":[{"name":"University of Maryland, College Park, College Park, MD, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kimber","family":"Debelak","sequence":"additional","affiliation":[{"name":"Recovery Pathways, Bay City, MI, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William R.","family":"Morrone","sequence":"additional","affiliation":[{"name":"Central Michigan University, College of Medicine, Departments of Family Medicine and Psychiatry, Saginaw, MI, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hendr\u03ade E.","family":"Jones","sequence":"additional","affiliation":[{"name":"Substance Abuse Treatment Evaluations and Interventions Research Program, RTI International, Research Triangle Park, NC, USA, and Departments of Psychiatry and Behavioral Sciences and Obstetrics and Gynecology, Johns Hopkins University School of Medicine, Baltimore, MD, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2013,3,14]]},"reference":[{"key":"bibr1-SART.S10955","doi-asserted-by":"publisher","DOI":"10.1038\/219180a0"},{"key":"bibr2-SART.S10955","doi-asserted-by":"publisher","DOI":"10.1111\/j.1360-0443.2006.01321.x"},{"key":"bibr3-SART.S10955","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugalcdep.2004.11.013"},{"key":"bibr4-SART.S10955","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1005359"},{"key":"bibr5-SART.S10955","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugalcdep.2008.01.025"},{"key":"bibr6-SART.S10955","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugalcdep.2005.10.001"},{"key":"bibr7-SART.S10955","doi-asserted-by":"publisher","DOI":"10.1055\/s-2004-821005"},{"issue":"1","key":"bibr8-SART.S10955","first-page":"80","volume":"29","author":"Binder T.","year":"2008","journal-title":"Neuroendocrinology Letters."},{"key":"bibr9-SART.S10955","doi-asserted-by":"publisher","DOI":"10.1007\/s11096-007-9176-1"},{"key":"bibr10-SART.S10955","doi-asserted-by":"publisher","DOI":"10.1046\/j.1360-0443.2000.95223910.x"},{"key":"bibr11-SART.S10955","doi-asserted-by":"publisher","DOI":"10.1016\/S0376-8716(03)00062-0"},{"key":"bibr12-SART.S10955","doi-asserted-by":"publisher","DOI":"10.1046\/j.1360-0443.2003.00245.x"},{"key":"bibr13-SART.S10955","doi-asserted-by":"publisher","DOI":"10.1016\/j.ntt.2009.09.001"},{"key":"bibr14-SART.S10955","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa022164"},{"key":"bibr15-SART.S10955","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.2010.352"},{"key":"bibr16-SART.S10955","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0866-05.2005"},{"key":"bibr17-SART.S10955","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2826.2005.01272.x"},{"key":"bibr18-SART.S10955","unstructured":"CzerkesM.BlacstoneJ.PulvinoJ. 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