{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,6,3]],"date-time":"2023-06-03T04:24:06Z","timestamp":1685766246244},"reference-count":46,"publisher":"American Society of Consultant Pharmacists","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["sr care pharm"],"published-print":{"date-parts":[[2023,6,1]]},"abstract":"<jats:p><jats:bold>Background<\/jats:bold> There are three commonly used sets of criteria to diagnose serotonin syndrome and all three diagnostic tools have all been shown to have shortcomings that do not fully encompass the possible symptoms of serotonin toxicity.  <jats:bold>Objective<\/jats:bold> To describe\n a case of an atypical presentation of possible drug-induced serotonin syndrome, characterized by hypothermia, night sweats, muscle tremors, and confusion.  <jats:bold>Setting<\/jats:bold> A rural and medically underserved area in eastern Washington State.  <jats:bold>Practice Description<\/jats:bold> This\n patient case was identified as a part of a project to identify and intervene with complex and high-risk patients from local rural and underserved populations. The pharmacist identified the symptoms of possible drug-induced serotonin syndrome during a comprehensive medication review with the\n patient.  <jats:bold>Results<\/jats:bold> The pharmacist identified a possible case of drug-induced serotonin syndrome and made a recommendation to the patient\u2019s physician that led to discontinuation of both fluoxetine and trazodone. At the follow-up visit, the patient reported that his symptoms\n had resolved completely.  <jats:bold>Discussion<\/jats:bold> The three sets of diagnostic criteria for serotonin syndrome all include fever as a symptom, but do not list hypothermia. Effects at various 5-HT receptors and receptor subtypes have been linked to symptoms often seen in serotonin syndrome,\n but there are gaps in the currently used diagnostic criteria.  <jats:bold>Conclusion<\/jats:bold> Pharmacists\u2019 comprehensive review of medications can allow identification of symptoms, such as hypothermia to identify possible serotonin syndrome.<\/jats:p>","DOI":"10.4140\/tcp.n.2023.223","type":"journal-article","created":{"date-parts":[[2023,5,26]],"date-time":"2023-05-26T10:51:43Z","timestamp":1685098303000},"page":"223-232","source":"Crossref","is-referenced-by-count":0,"title":["Hypothermia as a Possible Symptom of Serotonin Toxicity: A Case Report"],"prefix":"10.4140","volume":"38","author":[{"given":"Kimberly C.","family":"McKeirnan","sequence":"first","affiliation":[{"name":"1 Washington State University College of Pharmacy and Pharmaceutical Sciences, Pharmacotherapy Department, Spokane, Washington."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kavya","family":"Vaitla","sequence":"additional","affiliation":[{"name":"1 Washington State University College of Pharmacy and Pharmaceutical Sciences, Pharmacotherapy Department, Spokane, Washington."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rubi","family":"Gilbert","sequence":"additional","affiliation":[{"name":"2 Aging and Long-Term Care of Eastern Washington, Spokane, Washington."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Candace B.","family":"Anderson","sequence":"additional","affiliation":[{"name":"3 Medication Review, Inc., Spokane, Washington."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Megan R.","family":"Undeberg","sequence":"additional","affiliation":[{"name":"1 Washington State University College of Pharmacy and Pharmaceutical Sciences, Pharmacotherapy Department, Spokane, Washington."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2625","reference":[{"issue":"3","key":"ref1","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.1016\/S0021-9258(18)57137-4","article-title":"Serum vasoconstrictor, serotonin; 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