{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T13:53:37Z","timestamp":1761746017097},"reference-count":14,"publisher":"American Society of Consultant Pharmacists","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["sr care pharm"],"published-print":{"date-parts":[[2024,7,1]]},"abstract":"<jats:p>Parkinson's disease (PD) is a debilitating condition that affects 1.8% of people 65 years of age and older. Patients with PD often require hospitalization and are frequently admitted through the emergency department (ED). Notably, their hospital durations tend to be lengthier compared\n with patients without PD. The primary outcome of this research was to compare the length of stay (LOS) of patients who received carbidopa-levodopa (CL) in the ED with those who did not. Secondary outcomes included 30-day-readmission rates and administration of injectable for agitation. In\n addition, the percentage of patients receiving CL before and after an information management technology (IMT) alert implementation was compared in a sub-analysis. Patients that received CL during their inpatient stay were identified by a database report in this retrospective study. Patients\n were excluded if they were not admitted through the ED, younger than 65 years of age, or admitted to the intensive care unit after the ED. There was a total of 266 in the control group and 217 patients in the intervention group. The intervention group had a significantly shorter LOS than the\n control group (3.29 vs 5.37 days; <jats:italic>P<\/jats:italic> = 0.002), significantly less frequent 30-day readmissions (<jats:italic>P<\/jats:italic> = 0.032), and used fewer injectables for agitation (<jats:italic>P<\/jats:italic> = 0.035). The sub-analysis of the IMT alert revealed that prior to the alert's implementation, 28.5% of patients received\n CL in the ED; whereas post-alert, this percentage increased to 91.4% (<jats:italic>P<\/jats:italic> &lt; 0.001). The results of this study found that the group of PD patients who received CL in the ED had shorter LOS, lower 30-day readmissions, and used less injectables for agitation compared with the group that\n did not receive CL in the ED. This improvement is possibly due to continuity of CL supply considering its short half-life and clinical importance for PD.<\/jats:p>","DOI":"10.4140\/tcp.n.2024.242","type":"journal-article","created":{"date-parts":[[2024,6,28]],"date-time":"2024-06-28T04:30:28Z","timestamp":1719549028000},"page":"242-248","source":"Crossref","is-referenced-by-count":1,"title":["Improved Outcomes When Home-Dose Carbidopa-Levodopa Is Continued in the Geriatric Emergency Department in Patients With Parkinson\u2019s Disease"],"prefix":"10.4140","volume":"39","author":[{"given":"Jaylan M.","family":"Yuksel","sequence":"first","affiliation":[{"name":"1 Upstate Community Hospital, 4900 Broad Road, Syracuse, New York."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kelly R.","family":"Ulen","sequence":"additional","affiliation":[{"name":"1 Upstate Community Hospital, 4900 Broad Road, Syracuse, New York."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jay M.","family":"Brenner","sequence":"additional","affiliation":[{"name":"1 Upstate Community Hospital, 4900 Broad Road, Syracuse, New York."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sharon A.","family":"Brangman","sequence":"additional","affiliation":[{"name":"2 Upstate University Hospital, 750 East Adam Street, Syracuse, New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Noviasky","sequence":"additional","affiliation":[{"name":"1 Upstate Community Hospital, 4900 Broad Road, Syracuse, New York."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2625","reference":[{"key":"ref1","journal-title":"Get It On Time\u2014The Case for Improving Medication Management for Parkinson\u2019s"},{"issue":"2","key":"ref2","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1002\/mds.23449","article-title":"Clinical problems in the hospitalized Parkinson\u2019s disease patient: systematic review","volume":"26","year":"2011","journal-title":"Mov Disord"},{"issue":"4","key":"ref3","doi-asserted-by":"crossref","first-page":"e0124356","DOI":"10.1371\/journal.pone.0124356","article-title":"Missing dosages and neuroleptic usage may prolong length of stay in hospitalized Parkinson\u2019s disease patients","volume":"10","year":"2015","journal-title":"PLoS One"},{"issue":"4","key":"ref4","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/j.parkreldis.2011.12.007","article-title":"Assessment of appropriate medication administration for hospitalized patients with Parkinson\u2019s disease.","volume":"18","year":"2012","journal-title":"Parkinsonism Relat Disord"},{"issue":"7","key":"ref5","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1310\/hpj5007-559","article-title":"Delayed administration and contraindicated drugs place hospitalized Parkinson\u2019s disease patients at risk; doxorubicin liposomal mix-up; avoid mix-ups between hydroxyprogesterone and medroxyprogesterone","volume":"50","year":"2015","journal-title":"Hosp Pharm"},{"key":"ref6","volume-title":"Sinemet (Carbidopa-Levodopa) [package insert]","year":"2014"},{"key":"ref7","first-page":"100076","article-title":"Adherence to a strict medication protocol can reduce length of stay in hospitalized patients with Parkinson\u2019s disease","volume":"3","year":"2020","journal-title":"Clin Park Relat Disord"},{"issue":"4","key":"ref8","doi-asserted-by":"crossref","first-page":"1551","DOI":"10.3233\/JPD-202024","article-title":"Quality improvement in Parkinson\u2019s disease: a successful program to enhance timely administration of levodopa in the hospital","volume":"10","year":"2020","journal-title":"J Parkinsons Dis"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.parkreldis.2016.11.004","article-title":"Delayed administration of dopaminergic drugs is not associated with prolonged length of stay of hospitalized patients with Parkinson\u2019s disease","volume":"35","year":"2017","journal-title":"Parkinsonism Relat Disord"},{"issue":"8","key":"ref10","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1016\/j.parkreldis.2006.11.006","article-title":"Prescribing medications in Parkinson\u2019s disease (PD) patients during acute admissions to a District General Hospital","volume":"13","year":"2007","journal-title":"Parkinsonism Relat Disord"},{"issue":"1","key":"ref11","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/14737175.2017.1392857","article-title":"It is dopey to stop giving dopamine to hospitalized patients with Parkinson\u2019s disease","volume":"18","year":"2018","journal-title":"Exp Rev Neurother"},{"issue":"3","key":"ref12","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1111\/imj.14782","article-title":"Reducing medication errors for hospital inpatients with parkinsonism","volume":"51","year":"2021","journal-title":"Intern Med J"},{"issue":"1","key":"ref13","first-page":"23","article-title":"Interventions to minimize complications in hospitalized patients with Parkinson disease","volume":"10","year":"2019","journal-title":"Neurology: Clinical Practice"},{"issue":"3","key":"ref14","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.parkreldis.2010.11.009","article-title":"Management of the hospitalized patient with Parkinson\u2019s disease: current state of the field and need for guidelines.","volume":"17","year":"2011","journal-title":"Parkinsonism Relat Disord"}],"container-title":["The Senior Care Pharmacist"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ingentaconnect.com\/content\/ascp\/tscp\/2024\/00000039\/00000007\/art00003","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,3]],"date-time":"2024-07-03T04:47:39Z","timestamp":1719982059000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ingentaconnect.com\/content\/10.4140\/TCP.n.2024.242"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7,1]]},"references-count":14,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2024,7,1]]}},"alternative-id":["2639-9636(20240701)39:7L.242;1-"],"URL":"https:\/\/doi.org\/10.4140\/tcp.n.2024.242","relation":{},"ISSN":["2639-9636"],"issn-type":[{"value":"2639-9636","type":"print"}],"subject":[],"published":{"date-parts":[[2024,7,1]]}}}