{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T05:30:27Z","timestamp":1787031027944,"version":"build-2736575974"},"reference-count":57,"publisher":"American Society of Consultant Pharmacists","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["sr care pharm"],"published-print":{"date-parts":[[2025,9,1]]},"abstract":"<jats:p>As life expectancy increases, the older adult population is expected to grow significantly. As a result, gout cases continue to escalate in both incidence and prevalence. Gout is a chronic inflammatory condition that disproportionately affects older adults, certain racial and ethnic\n groups, and underserved populations. Risk factors for gout include renal impairment, genetics, select medications, obesity, and lifestyle factors. It is also associated with numerous comorbidities, such as cardiovascular disease, metabolic syndromes, chronic kidney disease (CKD), depression,\n and anxiety. This article examines the prevalence, pathophysiology, and risk factors of gout in the aging population. It highlights the unique challenges of managing gout in older adults, including polypharmacy, declining renal function, and the presence of other chronic conditions. The roles\n of diet, medication use, and lifestyle in the development and exacerbation of gout are discussed, with special attention to the complexities these factors introduce in geriatric care. The goal of this review is to equip clinicians with the knowledge needed to provide optimal care for older\n adults living with gout, as the need for this service continues to rise.<\/jats:p>","DOI":"10.4140\/tcp.n.2025.365","type":"journal-article","created":{"date-parts":[[2025,8,31]],"date-time":"2025-08-31T04:30:43Z","timestamp":1756614643000},"page":"365-372","source":"Crossref","is-referenced-by-count":5,"title":["Perspectives on the Epidemiology of Hyperuricemia and Gout in Older Adults"],"prefix":"10.4140","volume":"40","author":[{"given":"Madison W.","family":"Carter","sequence":"first","affiliation":[{"name":"1 Boise VA Medical Center, Boise, Idaho."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Youssef M.","family":"Roman","sequence":"additional","affiliation":[{"name":"1 Boise VA Medical Center, Boise, Idaho."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2625","reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"1455726","DOI":"10.3389\/fpubh.2025.1455726","article-title":"The changing burden of gout in adults aged 70 and above based on the global burden of disease 2019.","volume":"13","journal-title":"Front Public Health."},{"key":"ref2","article-title":"monitoring health for the SDGs, Sustainable Development Goals.","year":"2024"},{"issue":"11","key":"ref3","doi-asserted-by":"crossref","first-page":"1592","DOI":"10.1136\/annrheumdis-2019-215933","article-title":"Gout, Hyperuricaemia and Crystal-Associated Disease Network (G-CAN) consensus statement regarding labels and definitions of disease states of gout.","volume":"78","year":"2019","journal-title":"Ann Rheum Dis."},{"issue":"1","key":"ref4","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1186\/1757-1146-4-13","article-title":"Revisiting the pathogenesis of podagra: why does gout target the foot?","volume":"4","year":"2011","journal-title":"J Foot Ankle Res."},{"issue":"1","key":"ref5","doi-asserted-by":"crossref","first-page":"1","DOI":"10.5371\/hp.2024.36.1.1","article-title":"Pathophysiology and treatment of gout arthritis; 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