{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T20:43:06Z","timestamp":1792442586249,"version":"4.5.0"},"reference-count":21,"publisher":"American Society of Consultant Pharmacists","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["sr care pharm"],"published-print":{"date-parts":[[2026,8,1]]},"abstract":"<jats:p>\n                    <jats:bold>Purpose:<\/jats:bold>\n                    Bloodstream infections (BSIs) require prompt, targeted antimicrobial therapy, but traditional blood culture methods may delay optimal treatment. The BIOFIRE\u00ae Blood Culture Identification 2 (BCID2) panel provides rapid pathogen identification and mayreduce time\n to targeted therapy. This study evaluated the impact of BCID2 implementation at a community teaching hospital.\n                    <jats:bold>Methods:<\/jats:bold>\n                    A retrospective, quasi-experimental pre\/post study was conducted at a for-profit community teaching hospital in adults aged \u226518 years with BSIs. Eligible\n patients had bacteremia, blood cultures collected, and empiric antibiotic therapy initiated during the study periods. Exclusion criteria included pregnancy, detection of multiple pathogens in a single culture, availability of susceptibility results before the designated timeline, and discharge,\n transfer, or leaving against medical advice before completion of testing. The pre-implementation group included 64 patients (October-December 2023), and the postimplementation group included 60 patients (October 2024-February 2025). The primary outcome was time from blood culture collection\n to initiation of targeted antibiotic therapy based on final susceptibility results. Secondary outcomes included pathogen identification, empiric and total antibiotic use, and length of stay.\n                    <jats:bold>Results:<\/jats:bold>\n                    The study included 124 patients (mean age, 70.5 \u00b1 17.3 years; 67%\n \u226565 years; 50% male). Blood cultures were ordered for suspected sepsis\/septic shock in 58% of patients and suspected secondary bacteremia in 42%. Pathogen distribution was similar between groups, with\n                    <jats:italic>Escherichia coli<\/jats:italic>\n                    ,\n                    <jats:italic>Staphylococcus epidermidis<\/jats:italic>\n                    ,\n                    <jats:italic>Enterococcus faecalis<\/jats:italic>\n                    ,\n and\n                    <jats:italic>Staphylococcus aureus<\/jats:italic>\n                    identified most frequently. BCID2 implementation significantly reduced time to optimal therapy (3.73 \u00b1 2.01 vs. 2.02 \u00b1 1.48 days, p&lt;0.001) and empiric antibiotic duration (3.73 \u00b1 2.01 vs. 2.04 \u00b1 1.48 days, p &lt; 0.001). Total\n antibiotic duration and length of stay did not differ significantly between groups.\n                    <jats:bold>Conclusion:<\/jats:bold>\n                    BCID2 implementation at a community hospital significantly shortened time to optimal therapy and reduced empiric antibiotic use among older hospitalized adults.\n                  <\/jats:p>","DOI":"10.4140\/tcp.n.2026.198","type":"journal-article","created":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T08:34:19Z","timestamp":1786350859000},"page":"198-210","source":"Crossref","is-referenced-by-count":0,"title":["Effect of Rapid Molecular Diagnostic Implementation on Time to Targeted Antibiotic Treatment for Bloodstream Infections: A Before-and-After Study at a Community Teaching Hospital"],"prefix":"10.4140","volume":"41","author":[{"given":"Brant","family":"Botill","sequence":"first","affiliation":[{"name":"1Cleveland Clinic Martin, Stuart, FL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lan","family":"Bui","sequence":"additional","affiliation":[{"name":"2Palm Beach Atlantic University, Lloyd L. Gregory School of Pharmacy, West Palm Beach, FL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Collins","sequence":"additional","affiliation":[{"name":"3Wellington Regional Medical Center, Wellington, FL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ariel","family":"Hearing","sequence":"additional","affiliation":[{"name":"3Wellington Regional Medical Center, Wellington, FL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erenie","family":"Guirguis","sequence":"additional","affiliation":[{"name":"2Palm Beach Atlantic University, Lloyd L. Gregory School of Pharmacy, West Palm Beach, FL"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2625","reference":[{"issue":"6","key":"ref1","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1007\/s40266-023-01019-3","article-title":"Safety and tolerability of antimicrobial agents in the older patient.","volume":"40","year":"2023","journal-title":"Drugs Aging."},{"issue":"4","key":"ref2","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1016\/j.cmi.2021.10.022","article-title":"Estimating daily antibiotic harms: an umbrella review with individual study meta-analysis.","volume":"28","year":"2022","journal-title":"Clin Microbiol Infect."},{"issue":"11","key":"ref3","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1056\/NEJMoa2404991","article-title":"Antibiotic treatment for 7 versus 14 days in patients with bloodstream infections.","volume":"392","year":"2025","journal-title":"N Engl J Med."},{"issue":"10","key":"ref4","first-page":"18051812","article-title":"Shorter and longer courses of antibiotics for common infections and the association with reductions of infection-related complications including hospital admissions.","volume":"73","year":"2021","journal-title":"Clin Infect Dis."},{"issue":"4","key":"ref5","first-page":"725","article-title":"Surviving sepsis campaign: international guidelines for management of sepsis and septic shock 2026.","volume":"54","journal-title":"2026;"},{"issue":"3","key":"ref6","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1093\/cid\/ciac727","article-title":"Association between time to appropriate antimicrobial treatment and 30-day mortality in patients with bloodstream infections: a retrospective cohort study.","volume":"76","year":"2023","journal-title":"Clin Infect Dis."},{"issue":"9","key":"ref7","doi-asserted-by":"crossref","first-page":"e0223122","DOI":"10.1371\/journal.pone.0223122","article-title":"The impact of a rapid molecular identification test on positive blood cultures from critically ill with bacteremia: A pre-post intervention study.","volume":"14","year":"2019","journal-title":"PLoS One."},{"issue":"12","key":"ref8","first-page":"e00500","article-title":"Blood culture turnaround time in US acute care hospitals and implications for laboratory process pptimization.","volume":"56","year":"2018","journal-title":"J Clin Microbiol."},{"issue":"9","key":"ref9","doi-asserted-by":"crossref","first-page":"1254","DOI":"10.1001\/jamainternmed.2016.3646","volume":"176","year":"2016","journal-title":"JAMA Intern Med."},{"issue":"7","key":"ref10","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1093\/cid\/ciy1054","article-title":"Seven versus 14 days of antibiotic therapy for uncomplicated gram-negative bacteremia: a noninferiority randomized controlled trial.","volume":"69","year":"2019","journal-title":"Clin Infect Dis."},{"issue":"7","key":"ref11","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1093\/cid\/ciy1057","article-title":"Shortening antibiotic treatment durations for Bacteremia.","volume":"69","year":"2019","journal-title":"Clin Infect Dis."},{"issue":"1","key":"ref12","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1186\/s12879-023-08732-9","article-title":"Identification of microorganisms by a rapid PCR panel from positive blood cultures leads to faster optimal antimicrobial therapy - a before-after study.","volume":"23","year":"2023","journal-title":"BMC Infect Dis."},{"issue":"7","key":"ref13","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1093\/cid\/civ447","article-title":"Randomized trial of rapid multiplex polymerase chain reaction-based blood culture identification and susceptibility testing.","volume":"61","year":"2015","journal-title":"Clin Infect Dis."},{"issue":"3","key":"ref14","first-page":"e00095","article-title":"The cost-effectiveness of rapid diagnostic testing for the diagnosis of bloodstream infections with or without antimicrobial stewardship.","volume":"31","year":"2018","journal-title":"Clin Microbiol Rev."},{"key":"ref15","article-title":"BioFire Diagnostics, Salt Lake City, UT;","year":"2020"},{"issue":"1","key":"ref16","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1093\/cid\/ciw649","article-title":"The effect of molecular rapid diagnostic testing on clinical outcomes in bloodstream infections: a systematic review and meta-analysis.","volume":"64","year":"2017","journal-title":"Clin Infect Dis."},{"key":"ref17","article-title":"Impact of the BioFire FilmArray Blood Culture Identification 2 (BCID2) panel on time to antimicrobial escalation or de-escalation in a community health system.","year":"2023","journal-title":"Open Forum Infect Dis."},{"issue":"4","key":"ref18","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1111\/apm.13374","article-title":"FilmArray (BCID2) provides essential and timely results in bloodstream infections in small acute care hospitals without conventional microbiology services.","volume":"132","year":"2024","journal-title":"APMIS."},{"issue":"5","key":"ref19","first-page":"538","article-title":"Antibiotic stewardship programs in U.S. acute care hospitals: implementation according to CDC recommendations.","volume":"37","year":"2016","journal-title":"Infect Control Hosp Epidemiol."},{"issue":"4","key":"ref20","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1093\/cid\/cix407","article-title":"Antibiotic stewardship in small hospitals: barriers and potential solutions.","volume":"65","year":"2017","journal-title":"Clin Infect Dis"},{"issue":"10","key":"ref21","doi-asserted-by":"crossref","first-page":"5682","DOI":"10.1128\/AAC.00439-16","article-title":"Impact of infectious diseases consultation on clinical outcomes of patients with Staphylococcus aureus bacteremia in a community health system.","volume":"60","year":"2016","journal-title":"Antimicrob Agents Chemother"}],"container-title":["The Senior Care Pharmacist"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ingentaconnect.com\/content\/ascp\/tscp\/2026\/00000041\/00000005\/art00007","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T20:30:30Z","timestamp":1792441830000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ingentaconnect.com\/content\/10.4140\/TCP.n.2026.198"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,1]]},"references-count":21,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,8,1]]}},"alternative-id":["2639-9636(20260801)41:5L.198;1-"],"URL":"https:\/\/doi.org\/10.4140\/tcp.n.2026.198","relation":{},"ISSN":["2639-9636"],"issn-type":[{"value":"2639-9636","type":"print"}],"subject":[],"published":{"date-parts":[[2026,8,1]]}}}