{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T05:12:30Z","timestamp":1778044350759,"version":"3.51.4"},"reference-count":19,"publisher":"American Society of Consultant Pharmacists","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["sr care pharm"],"published-print":{"date-parts":[[2026,2,1]]},"abstract":"<jats:p>\n                    <jats:bold>Background<\/jats:bold>\n                    Propofol is an intravenous hypnotic agent widely used for anesthesia and sedation in critically ill, mechanically ventilated patients due to its rapid onset and offset, which facilitate ventilator weaning and extubation. Despite these benefits, propofol's lipid\n emulsion formulation poses an infection risk and is associated with propofol-related infusion syndrome (PRIS). PRIS is characterized by acute bradycardia that is resistant to treatment and may progress to asystole.\n                    <jats:bold>Objectives<\/jats:bold>\n                    We report the case of a 76-year-old woman who\n sustained full-thickness burns covering 30% of her total body surface area, involving the chest, abdomen, bilateral upper extremities, and right leg. She was sedated with propofol during her critical care management. The patient's clinical course was closely monitored for complications, and\n risk factors associated with PRIS were assessed.\n                    <jats:bold>Results<\/jats:bold>\n                    The patient developed PRIS despite the absence of typical risk factors, including high-dose propofol exposure, steroid therapy, young age, or inborn errors of metabolism. Despite supportive care and efforts to mitigate\n PRIS progression, her clinical condition deteriorated, resulting in a fatal outcome.\n                    <jats:bold>Discussion<\/jats:bold>\n                    This case highlights a rare occurrence of PRIS in a patient without common risk factors, emphasizing the need for continued vigilance in monitoring, even in atypical cases. Further\n investigation into alternative risk factors and methods for early detection is warranted.\n                    <jats:bold>Conclusion<\/jats:bold>\n                    The senior care pharmacist plays an important role in the prevention, early detection, and management of PRIS. This case emphasizes the importance of daily clinical pharmacist\n reviews and highlights the critical role of senior care pharmacists in early identification and management of PRIS, even among low risk older adult patients receiving low-dose propofol regimens.\n                  <\/jats:p>","DOI":"10.4140\/tcp.n.2026.53","type":"journal-article","created":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T04:38:31Z","timestamp":1771303111000},"page":"53-59","source":"Crossref","is-referenced-by-count":1,"title":["Minimal Propofol Dosing Triggers Propofol-Related Infusion Syndrome (PRIS) in a Geriatric Burn Patient: A Brief Report of Complex Burn Pharmacokinetics"],"prefix":"10.4140","volume":"41","author":[{"given":"Courtney","family":"Rawitscher","sequence":"first","affiliation":[{"name":"1University of Texas Southwestern Medical School, Dallas, TX"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heidi N.","family":"Michaels","sequence":"additional","affiliation":[{"name":"2Parkland Memorial Hospital, Dallas, TX"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Audra","family":"Clark","sequence":"additional","affiliation":[{"name":"3University of Texas Southwestern Department of Surgery, Dallas, TX"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Janie","family":"Faris","sequence":"additional","affiliation":[{"name":"2Parkland Memorial Hospital, Dallas, TX"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2625","reference":[{"issue":"7","key":"ref1","first-page":"690","article-title":"Propofol infusion syndrome. Anaesthesia.","volume":"62","year":"2007"},{"issue":"10","key":"ref2","first-page":"e30383","article-title":"Propofol-related infusion syndrome: a clinical review.","volume":"14","year":"2022","journal-title":"Cureus"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"R169","DOI":"10.1186\/cc8145","article-title":"Incidence of propofol-related infusion syndrome in critically ill adults: a prospective, multicenter study.","volume":"13","year":"2009","journal-title":"Crit Care"},{"issue":"5","key":"ref4","first-page":"339","article-title":"Propofol infusion syndrome: update of clinical manifestation and pathophysiology.","volume":"75","year":"2009","journal-title":"Minerva Anestesiol"},{"key":"ref5","article-title":"Propofol-related infusion syndrome: a bibliometric analysis of the 100 Most-Cited Articles.","year":"2023","journal-title":"Cureus"},{"key":"ref6","first-page":"535540","article-title":"Sedation and pain management in burn patients.","volume":"44","year":"2017","journal-title":"Clin Plast Surg"},{"key":"ref7","first-page":"260385","article-title":"Propofol infusion syndrome in adults: a clinical update.","volume":"2015","year":"2015","journal-title":"Crit Care Res Pract"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1186\/s13054-015-1112-5","article-title":"Propofol infusion syndrome: a structured review of experimental studies and 153 published case reports.","volume":"19","year":"2015","journal-title":"Crit Care"},{"issue":"9181","key":"ref9","doi-asserted-by":"crossref","first-page":"866","DOI":"10.1016\/S0140-6736(05)75936-5","article-title":"Short-term propofol infusions in children.","volume":"354","year":"1999","journal-title":"Lancet"},{"issue":"1","key":"ref10","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1097\/00003246-200001000-00028","article-title":"Propofol impairment of mitochondrial respiration in isolated perfused guinea pig hearts determined by reflectance spectroscopy.","volume":"28","year":"2000","journal-title":"Crit Care Med"},{"issue":"12","key":"ref11","doi-asserted-by":"crossref","first-page":"2087","DOI":"10.1097\/00003246-199812000-00046","article-title":"Lactic acidemia and bradyarrhythmia in a child sedated with propofol.","volume":"26","year":"1998","journal-title":"Crit Care Med"},{"issue":"1","key":"ref12","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1213\/01.ANE.0000117285.12600.C1","article-title":"Clinical management of cardiogenic shock associated with prolonged propofol infusion.","volume":"99","year":"2004","journal-title":"Anesth Analg"},{"issue":"3","key":"ref13","first-page":"316","article-title":"Propofol infusion syndrome\u2014report of an adult fatality.","volume":"31","year":"2003","journal-title":"Anaesth Intensive Care"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1038\/clpt.1981.154","article-title":"A method for estimating the probability of adverse drug reactions.","volume":"30","year":"1981","journal-title":"Clin Pharmacol Ther"},{"issue":"1","key":"ref15","first-page":"46","article-title":"Application of beta-blockers in burn management.","volume":"35","year":"2022","journal-title":"Proc (Bayl Univ Med Cent)"},{"issue":"9","key":"ref16","first-page":"14171425","article-title":"The pathophysiology of propofol infusion syndrome: a simple name for a complex syndrome.","volume":"29","year":"2003","journal-title":"Intensive Care Med"},{"issue":"5","key":"ref17","doi-asserted-by":"crossref","first-page":"e364","DOI":"10.1097\/BCR.0000000000000053","article-title":"Severe heart failure and rhabdomyolysis associated with propofol infusion in a burn patient.","volume":"35","year":"2014","journal-title":"J Burn Care Res."},{"issue":"7","key":"ref18","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1016\/j.burns.2011.05.014","article-title":"Late-onset rhabdomyolysis in burn patients in the intensive care unit.","volume":"37","year":"2011","journal-title":"Burns"},{"issue":"2","key":"ref19","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.hrthm.2005.11.005","article-title":"Electrocardiographic changes predicting sudden death in propofol-related infusion syndrome.","volume":"3","year":"2006","journal-title":"Heart Rhythm"}],"container-title":["The Senior Care Pharmacist"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ingentaconnect.com\/content\/ascp\/tscp\/2026\/00000041\/00000002\/art00003","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T04:33:24Z","timestamp":1778042004000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ingentaconnect.com\/content\/10.4140\/TCP.n.2026.53"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,1]]},"references-count":19,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,2,1]]}},"alternative-id":["2639-9636(20260201)41:2L.53;1-"],"URL":"https:\/\/doi.org\/10.4140\/tcp.n.2026.53","relation":{},"ISSN":["2639-9636"],"issn-type":[{"value":"2639-9636","type":"print"}],"subject":[],"published":{"date-parts":[[2026,2,1]]}}}