{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T06:34:35Z","timestamp":1764570875828},"reference-count":27,"publisher":"Korean Cancer Association","issue":"2","license":[{"start":{"date-parts":[[2019,12,6]],"date-time":"2019-12-06T00:00:00Z","timestamp":1575590400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"funder":[{"name":"Fund of Natural Science Foundation of Guangdong Province","award":["2017A030310193"],"award-info":[{"award-number":["2017A030310193"]}]},{"name":"YatSen University","award":["16ykpy30"],"award-info":[{"award-number":["16ykpy30"]}]},{"name":"Science and Technology Projects of Guangdong Province","award":["2014A020212577"],"award-info":[{"award-number":["2014A020212577"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81700148"],"award-info":[{"award-number":["81700148"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["e-crt.org"],"crossmark-restriction":true},"short-container-title":["Cancer Res Treat"],"published-print":{"date-parts":[[2020,4,15]]},"abstract":"<jats:p>PurposeLymphoblastic lymphoma (LBL) is an invasive neoplasm of precursor T-cell or B-cell lineage. A broadly accepted standard treatment for adult LBL has not yet been defined.Materials and MethodsTo address this issue, we compared two chemotherapy regimens: a modified non-Hodgkin lymphoma Berlin\u2013Frankfurt\u2013Mu\u0308nster-95 (NHL-BFM-95) regimen and HyperCVAD\/MA. This retrospective study consecutively enrolled 207 adult LBL patients at two hospitals from 2000 to 2018. Univariate and multivariate analysis were used to assess prognostic factors.ResultsIn the present study, most clinical characteristics were similar between the two treatment groups except for age and lactate dehydrogenase (LDH) level. Patients treated with modified NHL-BFM-95 regimen tended to be younger and with elevated LDH level. The modified NHL-BFM- 95 regimen produced better treatment outcomes than those with HyperCVAD\/MA in patients with T-LBL or patients &lt; 40 years. Treatment with HyperCVAD\/MA, high Eastern Cooperative Oncology Group scores, and bone marrow involvement were independent risk factors in T-LBL. No patients interrupted treatment for severe adverse events.ConclusionThe results suggested that the modified regimen is well-tolerated and can produce the promising outcomes in patients with T-LBL or patients &lt; 40 years.<\/jats:p>","DOI":"10.4143\/crt.2019.542","type":"journal-article","created":{"date-parts":[[2019,12,6]],"date-time":"2019-12-06T08:16:30Z","timestamp":1575620190000},"page":"573-585","update-policy":"http:\/\/dx.doi.org\/10.4143\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["A Modified NHL-BFM-95 Regimen Produces Better Outcome Than HyperCVAD in Adult Patients with T-Lymphoblastic Lymphoma, a Two-Institution 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retrospective comparison of Escherichia coli and polyethylene glycol-conjugated asparaginase for the treatment of adolescents and adults with newly diagnosed acute lymphoblastic leukemia","author":"Liang","year":"2018"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.3109\/10428194.2011.596963"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdl426"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.3109\/0284186X.2013.855816"}],"container-title":["Cancer Research and 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