{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T20:41:52Z","timestamp":1774644112765,"version":"3.50.1"},"reference-count":15,"publisher":"Korean Cancer Association","issue":"3","license":[{"start":{"date-parts":[[2020,1,15]],"date-time":"2020-01-15T00:00:00Z","timestamp":1579046400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100002560","name":"Soonchunhyang University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002560","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["e-crt.org"],"crossmark-restriction":true},"short-container-title":["Cancer Res Treat"],"published-print":{"date-parts":[[2020,7,15]]},"abstract":"<jats:p>Myeloproliferative neoplasms (MPNs) are classified as chronic myeloid leukemia (CML) and Philadelphia chromosome-negative MPN. In MPN cases, the presence of a &lt;i&gt;BCR-ABL1&lt;\/i&gt; translocation with a coexisting mutation is exceptionally rare. Herein, we report the first documented patient with CML harboring &lt;i&gt;CALR&lt;\/i&gt; mutation in Korea. A 33-year-old woman was referred to our hospital in February 2015 with splenomegaly, leukocytosis, and thrombocytosis. She was diagnosed with CML and started receiving nilotinib. In October 2015, a major molecular response was observed, but thrombocytosis persisted. A repeat bone marrow (BM) examination revealed no specific findings. However, as thrombocytosis worsened, we changed nilotinib to dasatinib. In May 2019, owing to persistent thrombocytosis, we repeated the BM examination and found &lt;i&gt;CALR&lt;\/i&gt; mutation (15.97%) on the MPN\u2013next generation sequencing (NGS) test. We then retrospectively performed repeat MPN-NGS testing using the BM aspirate sample obtained in 2015 and found &lt;i&gt;CALR&lt;\/i&gt; mutation (10.64%).<\/jats:p>","DOI":"10.4143\/crt.2019.703","type":"journal-article","created":{"date-parts":[[2020,1,15]],"date-time":"2020-01-15T06:10:39Z","timestamp":1579068639000},"page":"987-991","update-policy":"https:\/\/doi.org\/10.4143\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Philadelphia+ Chronic Myeloid Leukemia with CALR Mutation: A Case Report and Literature Review"],"prefix":"10.4143","volume":"52","author":[{"given":"Seug Yun","family":"Yoon","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sun Young","family":"Jeong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Changgon","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min-Young","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jieun","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyoung-Ha","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Namsu","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jong-Ho","family":"Won","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2954","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc1413718"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2014-12-616847"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2015-03-632893"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-016-2827-3"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.4084\/mjhid.2016.002"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1111\/ijlh.12792"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.21037\/sci.2017.06.02"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.25249"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1097\/HS9.0000000000000029"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1111\/ijlh.12798"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1312542"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2014.3"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2014-03-530865"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2015.277"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.13932"}],"container-title":["Cancer Research and Treatment"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/e-crt.org\/upload\/pdf\/crt-2019-703.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/e-crt.org\/journal\/view.php?doi=10.4143\/crt.2019.703","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/e-crt.org\/upload\/pdf\/crt-2019-703.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,7,15]],"date-time":"2020-07-15T02:27:27Z","timestamp":1594780047000},"score":1,"resource":{"primary":{"URL":"http:\/\/e-crt.org\/journal\/view.php?doi=10.4143\/crt.2019.703"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,7,15]]},"references-count":15,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2020,7]]}},"URL":"https:\/\/doi.org\/10.4143\/crt.2019.703","relation":{},"ISSN":["1598-2998","2005-9256"],"issn-type":[{"value":"1598-2998","type":"print"},{"value":"2005-9256","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,7,15]]},"assertion":[{"value":"2019-11-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-01-13","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-01-15","order":2,"name":"published","label":"Published online","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-07-15","order":3,"name":"published","label":"Print publication","group":{"name":"publication_history","label":"Publication History"}}]}}