{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T05:30:33Z","timestamp":1787031033815,"version":"build-2736575974"},"reference-count":22,"publisher":"Korean Cancer Association","issue":"3","license":[{"start":{"date-parts":[[2020,3,18]],"date-time":"2020-03-18T00:00:00Z","timestamp":1584489600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":["e-crt.org"],"crossmark-restriction":true},"short-container-title":["Cancer Res Treat"],"published-print":{"date-parts":[[2020,7,15]]},"abstract":"<jats:p>PurposeThe purpose of this study was to compare ramosetron (RAM), aprepitant (APR), and dexamethasone (DEX) [RAD] with palonosetron (PAL), APR, and DEX [PAD] in controlling highly-emetogenic chemotherapy (HEC)\u2013induced nausea and vomiting. Materials and MethodsPatients were randomly assigned (1:1) to receive RAD or PAD:RAM (0.3 mg intravenously) or PAL (0.25 mg intravenously) D1, combined with APR (125 mg orally, D1 and 80 mg orally, D2-3) and DEX (12 mg orally or intravenously, D1 and 8 mg orally, D2-4). Patients were stratified by gender, cisplatin-based chemotherapy, and administration schedule. The primary endpoint was overall complete response (CR), defined as no emesis and no rescue regimen during 5 days of HEC. Secondary endpoints were overall complete protection (CP; CR+nausea score &lt; 25 mm) and total control (TC; CR+nausea score &lt; 5 mm). Quality of life was assessed by Functional Living Index Emesis (FLIE) questionnaire on D0 and D6.ResultsA total of 279 patients receiving RAD (n=137) or PAD (n=142) were evaluated. Overall CR rates in RAD and PAD recipients were 81.8% and 79.6% (risk difference [RD], 2.2%; 95% confidence interval [CI], \u22127.1 to 11.4), respectively. Overall CP and TC rates for RAD and PAD were 56.2% and 58.5% (RD, \u22122.3%; 95% CI, \u221213.9 to 9.4) and 47.5% vs. 43.7% (RD, 3.8%; 95% CI, \u22127.9 to 15.5), respectively. FLIE total score \u2265 108 (no impact on daily life) was comparable between RAD and PAD (73.9% vs. 73.4%, respectively). Adverse events were similar between the two groups.ConclusionIn all aspects of efficacy, safety and QOL, RAD is non-inferior to PAD for the control of CINV in cancer patients receiving HEC.<\/jats:p>","DOI":"10.4143\/crt.2019.713","type":"journal-article","created":{"date-parts":[[2020,3,18]],"date-time":"2020-03-18T00:45:36Z","timestamp":1584492336000},"page":"907-916","update-policy":"https:\/\/doi.org\/10.4143\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Ramosetron versus Palonosetron in Combination with Aprepitant and Dexamethasone for the Control of Highly-Emetogenic Chemotherapy-Induced Nausea and Vomiting"],"prefix":"10.4143","volume":"52","author":[{"given":"Jin Hyoung","family":"Kang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jung 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Jung","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2954","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-5394.1999.07205.x"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/S0885-3924(00)00249-9"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-012-1448-1"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2003.01.095"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1517\/14656566.4.12.2297"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.11817"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdg417"},{"key":"ref8","volume-title":"","year":"2020"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1358\/dot.2002.38.2.820104"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.4174\/astr.2014.87.1.9"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-003-0482-4"},{"key":"ref12","first-page":"13","volume-title":"Criteria 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Treatment"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/e-crt.org\/upload\/pdf\/crt-2019-713.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/e-crt.org\/journal\/view.php?doi=10.4143\/crt.2019.713","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/e-crt.org\/upload\/pdf\/crt-2019-713.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,7,14]],"date-time":"2020-07-14T22:27:11Z","timestamp":1594765631000},"score":1,"resource":{"primary":{"URL":"http:\/\/e-crt.org\/journal\/view.php?doi=10.4143\/crt.2019.713"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,7,15]]},"references-count":22,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2020,7]]}},"URL":"https:\/\/doi.org\/10.4143\/crt.2019.713","relation":{},"ISSN":["1598-2998","2005-9256"],"issn-type":[{"value":"1598-2998","type":"print"},{"value":"2005-9256","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,7,15]]},"assertion":[{"value":"2019-11-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication 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