{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,7,27]],"date-time":"2024-07-27T23:33:20Z","timestamp":1722123200293},"reference-count":28,"publisher":"Korean Cancer Association","issue":"1","license":[{"start":{"date-parts":[[2020,8,24]],"date-time":"2020-08-24T00:00:00Z","timestamp":1598227200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":["e-crt.org"],"crossmark-restriction":true},"short-container-title":["Cancer Res Treat"],"published-print":{"date-parts":[[2021,1,15]]},"abstract":"<jats:p>PurposeThe study aimed to assess the differences in dental maturation between childhood cancer survivors and healthy children.Materials and MethodsFifty-nine cancer patients including 16 (27.1%) girls and 43 (72.8%) boys, aged between 4 and 16 years, underwent dental and radiographic examinations. The mean duration of anticancer therapy was 16.8 months (range, 1 to 47 months), and 4.6 years (range, 8 to 123 months) had passed since the termination of disease. The control group consisted of 177 panoramic radiographs of age- and sex-matched healthy individuals. Dental age (DA) was estimated with Demirjian\u2019s scale and delta age, i.e., DA\u2013chronological age (CA), was used to compare groups. ResultsThe DA of cancer survivors was accelerated by almost 1 year compared to their CA (9.9\u00b13.1 vs. 8.9\u00b12.8, p=0.040). The greatest difference was observed among patients with brain tumor: delta (DA\u2013CA) was 2.2\u00b11.1 years. Among all cancer patients, only children with familial adenomatous polyposis (FAP)-associated hepatoblastoma (HP) demonstrated delayed DA, with regard to both other cancer survivors (p=0.011) and healthy patients (p=0.037). All four patients with HP suffered from FAP, and three of them had documented adenomatous polyposis coli (&lt;i&gt;APC&lt;\/i&gt;) genes mutation. The DA of cancer patients having teeth with short roots was significantly greater than that of the cancer survivors without this anomaly (12.8\u00b13.2 vs. 9.0\u00b12.4, p &lt; 0.001).ConclusionDA in children may be altered by cancer disease.<\/jats:p>","DOI":"10.4143\/crt.2020.275","type":"journal-article","created":{"date-parts":[[2020,8,24]],"date-time":"2020-08-24T02:57:33Z","timestamp":1598237853000},"page":"252-260","update-policy":"http:\/\/dx.doi.org\/10.4143\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["The Broad Variability in Dental Age Observed among Childhood Survivors Is Cancer 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between body mass index and dental age in Hispanic children","author":"Chehab","year":"2017"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.4103\/jispcd.JISPCD_315_18"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1515\/JPEM.2009.22.8.715"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2014.01.013"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1007\/s00784-018-2501-3"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1136\/gut.39.6.867"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.37763"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1055\/s-0039-1697380"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajodo.2011.08.026"}],"container-title":["Cancer Research and 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