{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T03:06:21Z","timestamp":1781579181353,"version":"3.54.5"},"reference-count":17,"publisher":"Korean Cancer Association","issue":"1","license":[{"start":{"date-parts":[[2020,8,11]],"date-time":"2020-08-11T00:00:00Z","timestamp":1597104000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100003645","name":"National Cancer Center","doi-asserted-by":"publisher","award":["NCC-1911274"],"award-info":[{"award-number":["NCC-1911274"]}],"id":[{"id":"10.13039\/501100003645","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["e-crt.org"],"crossmark-restriction":true},"short-container-title":["Cancer Res Treat"],"published-print":{"date-parts":[[2021,1,15]]},"abstract":"PurposeThe <i>BRCA1<\/i> or <i>BRCA2<\/i> gene is transmitted in an autosomal dominant fashion, and genetic testing of first-degree relatives of patients with family-specific mutation (FSM) is recommended. This study examined factors affecting the uptake of FSM testing among relatives of patients with peritoneal, ovarian, or fallopian tube (POFT) cancer with confirmed <i>BRCA1<\/i> or <i>BRCA2<\/i> germline mutation.Materials and MethodsData from medical charts of 392 eligible patients and their relatives who had undergone outpatient genetic counseling\/testing were retrospectively reviewed. Clinical factors were compared between family members who had and had not undergone genetic counseling\/testing.ResultsThe uptake of FSM testing was 30.5% (129\/423) among first-degree living relatives and 53.5% (69\/129) within the overall family unit. The average time from genetic testing of the proband to the first FSM test within a family was 168 days (range, 23 to 681 days). Having a living father (33.8% vs. 13.3%, p=0.007) and daughter (79.4% vs. 60.3%, p=0.019) increased the uptake of FSM testing. FSM testing was more likely among female than among male relatives of cancer patients (40.9% vs. 17.6%, p < 0.001).ConclusionApproximately one-third of first-degree relatives of patients with a POFT cancer with <i>BRCA1<\/i> or <i>BRCA2<\/i> mutation underwent FSM testing. Having a living father or daughter was a factor affecting the uptake of FSM testing, which was higher among female than among male relatives of the proband. This discrepancy might be due to a misconception that the <i>BRCA<\/i> gene is associated with women rather than with men.<\/jats:p>","DOI":"10.4143\/crt.2020.364","type":"journal-article","created":{"date-parts":[[2020,8,11]],"date-time":"2020-08-11T04:40:23Z","timestamp":1597120823000},"page":"207-211","update-policy":"https:\/\/doi.org\/10.4143\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Uptake of Family-Specific Mutation Genetic Testing Among Relatives of Patients with Ovarian Cancer with BRCA1 or BRCA2 Mutation"],"prefix":"10.4143","volume":"53","author":[{"given":"Go Woon","family":"Jeong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wonkyo","family":"Shin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong Ock","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sang-Soo","family":"Seo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sokbom","family":"Kang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sang-Yoon","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Myong Cheol","family":"Lim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2954","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2015.61.2408"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1007\/s00432-009-0607-3"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1097\/IGC.0000000000000529"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1111\/j.1349-7006.2004.tb02195.x"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.6004\/jnccn.2017.0003"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.3802\/jgo.2016.27.e36"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2017.73.6314"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2019.01.024"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21408"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1097\/01.GIM.0000144014.91237.A1"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1007\/s10897-013-9592-4"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1086\/318187"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1038\/d41586-019-02775-2"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-018-4098-y"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1007\/s10689-013-9624-0"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1186\/s13048-019-0594-1"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.3390\/cancers10110424"}],"container-title":["Cancer Research and Treatment"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/e-crt.org\/upload\/pdf\/crt-2020-364.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/e-crt.org\/journal\/view.php?doi=10.4143\/crt.2020.364","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/e-crt.org\/upload\/pdf\/crt-2020-364.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,1,14]],"date-time":"2021-01-14T08:08:03Z","timestamp":1610611683000},"score":1,"resource":{"primary":{"URL":"http:\/\/e-crt.org\/journal\/view.php?doi=10.4143\/crt.2020.364"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1,15]]},"references-count":17,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,1]]}},"URL":"https:\/\/doi.org\/10.4143\/crt.2020.364","relation":{},"ISSN":["1598-2998","2005-9256"],"issn-type":[{"value":"1598-2998","type":"print"},{"value":"2005-9256","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,1,15]]},"assertion":[{"value":"2020-04-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-08-08","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-08-11","order":2,"name":"published","label":"Published online","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-01-15","order":3,"name":"published","label":"Print publication","group":{"name":"publication_history","label":"Publication History"}}]}}