{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T18:05:22Z","timestamp":1793642722776,"version":"4.5.1"},"reference-count":14,"publisher":"Korean Cancer Association","issue":"1","license":[{"start":{"date-parts":[[2021,3,24]],"date-time":"2021-03-24T00:00:00Z","timestamp":1616544000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":["e-crt.org"],"crossmark-restriction":true},"short-container-title":["Cancer Res Treat"],"published-print":{"date-parts":[[2022,1,15]]},"abstract":"<jats:p>Purpose In 2017, the Children\u2019s Hepatic Tumors International Collaboration-Hepatoblastoma Stratification (CHIC-HS) system was introduced. We aimed to evaluate the accuracy of CHIC-HS System for the prediction of event-free survival (EFS) in Korean pediatric patients with hepatoblastoma.Materials and Methods This two-center retrospective study included consecutive Korean pediatric patients with histopathologically confirmed hepatoblastoma from March 1988 through September 2019. We compared EFS among four risk groups according to the CHIC-HS system. Discriminatory ability of CHIC-HS system was also evaluated using optimism-corrected C-statistics. Factors associated with EFS were explored using multivariable Cox regression analysis.Results We included 129 patients (mean age, 2.6\u00b13.3 years; female:male, 63:66). The 5-year EFS rates in the very low, low, intermediate, and high-risk groups, according to the CHIC-HS system were 90.0%, 82.8%, 73.5%, and 51.3%, respectively. The CHIC-HS system aligned significantly well with EFS outcomes (p=0.004). The optimism-corrected C index of CHIC-HS was 0.644 (95% confidence interval [CI], 0.561 to 0.727). Age \u2265 8 (vs. age \u2264 2; hazard ratio [HR], 2.781; 95% CI, 1.187 to 6.512; p=0.018), PRE-Treatment EXTent of tumor (PRETEXT) stage IV (vs. PRETEXT I or II; HR, 2.774; 95% CI, 1.228 to 5.974; p=0.009), and presence of metastasis (HR, 2.886; 95% CI, 1.457 to 5.719; p=0.002), which are incorporated as the first three nodes in the CHIC-HS system, were independently associated with EFS.Conclusion The CHIC-HS system aligned significantly well with EFS outcomes in Korean pediatric patients with hepatoblastoma. Age group, PRETEXT stage, and presence of metastasis were independently associated with EFS.<\/jats:p>","DOI":"10.4143\/crt.2021.265","type":"journal-article","created":{"date-parts":[[2021,3,24]],"date-time":"2021-03-24T05:37:58Z","timestamp":1616564278000},"page":"253-258","update-policy":"https:\/\/doi.org\/10.4143\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Children\u2019s Hepatic Tumors International Collaboration-Hepatoblastoma Stratification (CHIC-HS) System for Pediatric Patients with Hepatoblastoma: A Retrospective, Hospital-Based Cohort Study in South Korea"],"prefix":"10.4143","volume":"54","author":[{"given":"Pyeong Hwa","family":"Kim","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyun Joo","family":"Shin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hee 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Joo","family":"Lyu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jung Woo","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seung Min","family":"Hahn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young Ah","family":"Cho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2954","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1177\/1093526619875228"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1053\/jpsu.2001.22953"},{"key":"ref3","first-page":"19","volume-title":"Hepatoblastoma state of the art: pathology, genetics, risk stratification, and chemotherapy","author":"Czauderna","year":"2014"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1056\/nejmoa0810613"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1200\/jco.19.01067"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1055\/a-1014-3250"},{"key":"ref7","first-page":"29","volume-title":"Hepatoblastoma state of the art: pre-treatment extent of disease, surgical resection guidelines and the role of liver transplantation","author":"Meyers","year":"2014"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.24217"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016\/s1470-2045(16)30598-8"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.39335.541782.ad"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2008.10.026"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1002\/sim.6370"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1038\/srep20080"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2015.09.023"}],"container-title":["Cancer Research and 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