{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,22]],"date-time":"2025-11-22T17:07:19Z","timestamp":1763831239602},"reference-count":28,"publisher":"Korean Cancer Association","issue":"2","license":[{"start":{"date-parts":[[2021,8,10]],"date-time":"2021-08-10T00:00:00Z","timestamp":1628553600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"funder":[{"name":"Samsung Medical Center","award":["SMO1190181"],"award-info":[{"award-number":["SMO1190181"]}]}],"content-domain":{"domain":["e-crt.org"],"crossmark-restriction":true},"short-container-title":["Cancer Res Treat"],"published-print":{"date-parts":[[2022,4,15]]},"abstract":"<jats:p>PurposeChildren with Down syndrome (DS) show a higher risk of acute leukemia than those without DS. In this study, we investigated the nationwide incidence of acute leukemia among children with DS and compared their epidemiologic characteristics with those of children with acute leukemia but without DS.Materials and MethodsUsing the National Health Insurance Service database, we selected patients with acute leukemia aged 0\u201319 years at diagnosis between 2007 and 2016.ResultsAmong the 4,697 children with acute leukemia, 54 (1.1%) had DS. The median incidence rate of leukemia with DS by year was 1.3% (range, 0.2%\u20132.0%). Sixteen patients with acute lymphoblastic leukemia (ALL; 29.6%) and 36 with acute myeloid leukemia (AML; 66.7%) had DS. The DS group showed younger age at diagnosis than the non-DS group, and diagnosis of AML was more frequent in the DS group than in the non-DS group (3 years vs. 9 years, p&lt;0.001; 66.7% vs. 32.4%, P&lt;0.001, respectively). The 5-year overall survival was comparable between the DS and non-DS groups (88.0% vs. 81.9%, p=0.375). Among all the Koreans born between 2007 and 2008, the incidences of acute leukemia, ALL, and AML were 49.25, 20.75, and 163.38 times higher, respectively, in the DS group than in the non-DS group.ConclusionOur findings support the fact that the incidence of acute leukemia is higher among patients with DS than among those without DS in Korea. However, the DS and non-DS groups in this study had a comparable overall survival rate.<\/jats:p>","DOI":"10.4143\/crt.2021.368","type":"journal-article","created":{"date-parts":[[2021,8,10]],"date-time":"2021-08-10T06:02:46Z","timestamp":1628575366000},"page":"572-578","update-policy":"http:\/\/dx.doi.org\/10.4143\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Epidemiology of Acute Leukemia among Children with Down Syndrome in Korea"],"prefix":"10.4143","volume":"54","author":[{"given":"Young Bae","family":"Choi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keon Hee","family":"Yoo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2954","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/s1470-2045(11)70041-9"},{"key":"ref2","first-page":"289","volume-title":"Simultaneous occurrence of mongolism and leukemia: report of a nationwide survey","author":"Krivit","year":"1957"},{"key":"ref3","first-page":"1677","volume-title":"Myelodysplasia and acute myelogenous leukemia in Down\u2019s syndrome: a report of 40 children of the AML-BFM Study Group","author":"Creutzig","year":"1996"},{"key":"ref4","first-page":"608","volume-title":"Distinctive demography, biology, and outcome of acute myeloid leukemia and myelodysplastic syndrome in children with Down syndrome: Children\u2019s Cancer Group Studies 2861 and 2891","author":"Lange","year":"1998"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2401754"},{"key":"ref6","first-page":"512","volume-title":"The management of neoplastic disorders of haematopoiesis in children with Down\u2019s syndrome","author":"Lange","year":"2000"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2403814"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/0165-4608(87)90354-2"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1038\/nrc1525"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.20165"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.12831"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2005.05398.x"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2013-06-509463"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-10-3446"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.4093\/dmj.2014.38.5.395"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.14802\/jmd.14038"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2010.024968"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1007\/bf02982057"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1111\/ped.13776"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2403047"},{"key":"ref21","first-page":"519","volume-title":"The population prevalence, associations of congenital heart defect and mortality risk for Down\u2019s syndrome in South Korea based on National Health Insurance Service (NHIS) data","author":"Cho","year":"2020"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1111\/jir.12277"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1182\/blood.v99.1.245"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.20092"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2401753"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1200\/jco.1993.11.7.1361"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1136\/adc.81.3.202"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.31065"}],"container-title":["Cancer Research and Treatment"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/e-crt.org\/upload\/pdf\/crt-2021-368.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/e-crt.org\/journal\/view.php?doi=10.4143\/crt.2021.368","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/e-crt.org\/upload\/pdf\/crt-2021-368.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,13]],"date-time":"2022-04-13T02:21:14Z","timestamp":1649816474000},"score":1,"resource":{"primary":{"URL":"http:\/\/e-crt.org\/journal\/view.php?doi=10.4143\/crt.2021.368"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4,15]]},"references-count":28,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2022,4]]}},"URL":"https:\/\/doi.org\/10.4143\/crt.2021.368","relation":{},"ISSN":["1598-2998","2005-9256"],"issn-type":[{"value":"1598-2998","type":"print"},{"value":"2005-9256","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,4,15]]},"assertion":[{"value":"2021-03-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-08-09","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-08-10","order":2,"name":"published","label":"Published online","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-04-15","order":3,"name":"published","label":"Print publication","group":{"name":"publication_history","label":"Publication History"}}]}}