{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T12:37:20Z","timestamp":1771677440974,"version":"3.50.1"},"reference-count":22,"publisher":"Korean Cancer Association","issue":"4","license":[{"start":{"date-parts":[[2024,4,23]],"date-time":"2024-04-23T00:00:00Z","timestamp":1713830400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"funder":[{"name":"Korean Society of Otorhinolaryngology-Head and Neck Surgery"},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["RS-2023-00208625"],"award-info":[{"award-number":["RS-2023-00208625"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100014188","name":"Ministry of Science and ICT","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100014188","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["e-crt.org"],"crossmark-restriction":true},"short-container-title":["Cancer Res Treat"],"published-print":{"date-parts":[[2024,10,15]]},"abstract":"<jats:p>Purpose This study aimed to assess the long-term risks associated with a history of infectious mononucleosis (IM), primarily caused by the Epstein-Barr virus (EBV). Specifically analyzing the potential increase in developing nasopharyngeal cancer (NPC) and lymphoma in patients with a history of IM and exploring the prevalence of other EBV-associated conditions.Materials and Methods The Korean National Health Insurance Service (NHIS) database was utilized for a retrospective analysis, covering data from 2002 to 2021. A total of 25,582 IM patients and controls were included, with 1:1 propensity score matching. The study monitored outcomes, including lymphoma, NPC, gastric cancer, multiple sclerosis, and all-cause mortality.Results Patients with a history of IM demonstrated a significantly higher incidence of lymphoma (hazard ratio [HR], 5.320; 95% confidence interval [CI], 3.208 to 8.820; p &lt; 0.001) and NPC (HR, 7.116; 95% CI, 1.617 to 31.314; p=0.009) during the follow-up period compared with the control group. Additionally, the IM group showed an increased rate of all-cause mortality (HR, 2.225; 95% CI, 1.858 to 2.663; p &lt; 0.001).Conclusion This study suggests that individuals with a history of IM have an elevated risk of developing lymphoma and NPC in South Korea, emphasizing the importance of vigilant follow-up and monitoring. The results advocate for heightened awareness and potential national monitoring policies to address the long-term health implications of EBV infection and to implement preventive measures.<\/jats:p>","DOI":"10.4143\/crt.2023.1356","type":"journal-article","created":{"date-parts":[[2024,5,27]],"date-time":"2024-05-27T00:08:23Z","timestamp":1716768503000},"page":"1077-1083","update-policy":"https:\/\/doi.org\/10.4143\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["The Impact of Infectious Mononucleosis History on the Risk of Developing Lymphoma and Nasopharyngeal Carcinoma: A Retrospective Large-Scale Cohort Study Using National Health Insurance Data in South Korea"],"prefix":"10.4143","volume":"56","author":[{"given":"So Hee","family":"Kang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yun-Hee","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun-Pyo","family":"Myong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Minsu","family":"Kwon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2954","reference":[{"key":"ref1","first-page":"71","volume-title":"Infectious mononucleosis: rapid evidence review","author":"Sylvester","year":"2023"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcv.2018.03.001"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.587380"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1038\/s41579-022-00770-5"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/j.pathol.2019.09.006"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.pathol.2019.09.011"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1097\/qco.0000000000000787"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-pathmechdis-012418-013023"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016\/j.hoc.2021.05.007"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2019000568"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1038\/s41579-019-0249-7"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.4093\/dmj.2020.0207"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.23838\/pfm.2021.00135"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.4070\/kcj.2020.0171"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1136\/jclinpath-2019-205822"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016\/j.jiph.2015.05.004"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016\/j.pvr.2016.10.002"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1056\/nejmoa023141"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0115836"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.25633"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1186\/s12889-020-09049-x"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0261665"}],"container-title":["Cancer Research and Treatment"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/e-crt.org\/upload\/pdf\/crt-2023-1356.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/e-crt.org\/journal\/view.php?doi=10.4143\/crt.2023.1356","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/e-crt.org\/upload\/pdf\/crt-2023-1356.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,13]],"date-time":"2024-10-13T23:44:39Z","timestamp":1728863079000},"score":1,"resource":{"primary":{"URL":"http:\/\/e-crt.org\/journal\/view.php?doi=10.4143\/crt.2023.1356"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,15]]},"references-count":22,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2024,10]]}},"URL":"https:\/\/doi.org\/10.4143\/crt.2023.1356","relation":{},"ISSN":["1598-2998","2005-9256"],"issn-type":[{"value":"1598-2998","type":"print"},{"value":"2005-9256","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,10,15]]},"assertion":[{"value":"2023-12-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-04-22","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-04-23","order":2,"name":"published","label":"Published online","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-10-15","order":3,"name":"published","label":"Print publication","group":{"name":"publication_history","label":"Publication History"}}]}}