{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T12:57:15Z","timestamp":1777294635598,"version":"3.51.4"},"reference-count":29,"publisher":"Korean Cancer Association","issue":"1","license":[{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["e-crt.org"],"crossmark-restriction":true},"short-container-title":["Cancer Res Treat"],"published-print":{"date-parts":[[2024,1,15]]},"abstract":"<jats:p>Purpose Neoadjuvant chemotherapy (NACT) can change invasive breast carcinomas (IBC) and influence the patients\u2019 overall survival time (OS). We aimed to identify IBC changes after NACT and their association with OS.Materials and Methods IBC data in pre- and post-NACT samples of 86 patients were evaluated and associated with OS.Results Post-NACT tumors changed nuclear pleomorphism score (p=0.025); mitotic count (p=0.002); % of tumor-infiltrating inflammatory cells (p=0.016); presence of &lt;i&gt;in situ&lt;\/i&gt; carcinoma (p=0.001) and lymphovascular invasion (LVI; p=0.002); expression of estrogen (p=0.003), progesterone receptors (PR; p=0.019), and Ki67 (p=0.003). Immunohistochemical (IHC) profile changed in 26 tumors (30.2%, p=0.050). Higher risk of death was significatively associated with initial tumor histological grade III (hazard ratio [HR], 2.94), high nuclear pleomorphism (HR, 2.53), high Ki67 index (HR, 2.47), post-NACT presence of LVI (HR, 1.90), luminal B\u2013like profile (HR, 2.58), pre- (HR, 2.26) and post-NACT intermediate mitotic count (HR, 2.12), pre- (HR, 4.45) and post-NACT triple-negative IHC profile (HR, 4.52). On the other hand, lower risk of death was significative associated with pre- (HR, 0.35) and post-NACT (HR, 0.39) estrogen receptor\u2013positive, and pre- (HR, 0.37) and post-NACT (HR, 0.57) PR-positive. Changes in IHC profile were associated with longer OS (p=0.050). In multivariate analysis, pre-NACT grade III tumors and pre-NACT and post-NACT triple negative IHC profile proved to be independent factors for shorter OS.Conclusion NACT can change tumor characteristics and biomarkers and impact on OS; therefore, they should be reassessed on residual samples to improve therapeutic decisions.<\/jats:p>","DOI":"10.4143\/crt.2023.386","type":"journal-article","created":{"date-parts":[[2023,8,2]],"date-time":"2023-08-02T01:04:31Z","timestamp":1690938271000},"page":"178-190","update-policy":"https:\/\/doi.org\/10.4143\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Changes in Invasive Breast Carcinomas after Neoadjuvant Chemotherapy Can Influence Adjuvant Therapeutic Decisions"],"prefix":"10.4143","volume":"56","author":[{"given":"B\u00e1rbara","family":"Jaime dos Santos","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D\u00e9bora","family":"Balabram","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Virginia","family":"Mara Reis Gomes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carolina","family":"Costa Caf\u00e9 de Castro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paulo","family":"Henrique Costa Diniz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcelo","family":"Ara\u00fajo Buzelin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristiana","family":"Buzelin Nunes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2954","reference":[{"key":"ref1","first-page":"1245","volume-title":"Breast cancer biomarker changes after neoadjuvant chemotherapy: a single institution experience and literature review","author":"Reddy","year":"2017"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.21037\/atm-21-6924"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0247802"},{"key":"ref4","first-page":"1162","volume-title":"Impact of immunohistochemical profile changes following neoadjuvant therapy in the treatment of breast cancer","author":"Candas","year":"2021"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1186\/s12957-018-1332-7"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1200\/jco.2010.31.8469"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdv611"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1159\/000521880"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1200\/jco.2015.61.1459"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1038\/s41379-021-00738-5"},{"key":"ref11","volume-title":"Joint Ordinance No. 5, APRIL 18, 2019. Diagnostic and therapeutic guidelines for breast carcinoma [Internet]","year":"2019"},{"key":"ref12","first-page":"84","volume-title":"","year":"2020"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.1991.tb00229.x"},{"key":"ref14","first-page":"211","volume-title":"","author":"Amin","year":"2017"},{"key":"ref15","first-page":"545","volume-title":"Estrogen and progesterone receptor testing in breast cancer: American Society of Clinical Oncology\/College of American Pathologists guideline update","author":"Allison","year":"2020"},{"key":"ref16","first-page":"1364","volume-title":"Human epidermal growth factor receptor 2 testing in breast cancer: American Society of Clinical Oncology\/College of American Pathologists clinical practice guideline focused update","author":"Wolff","year":"2018"},{"key":"ref17","first-page":"299","volume-title":"Highlights from the 13th St Gallen International Breast Cancer Conference 2013. Access to innovation for patients with breast cancer: how to speed it up?","author":"Curigliano","year":"2013"},{"key":"ref18","first-page":"356","volume-title":"","year":"2019"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2017.02.005"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics11122249"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2021.668610"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.2147\/bctt.s94516"},{"key":"ref23","volume-title":"","author":"Bossuyt","year":"2023"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.4103\/0019-509x.112301"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/107.2.211"},{"key":"ref26","first-page":"1","volume-title":"Core needle biopsy of the breast: an evaluation of contemporary data","author":"Calhoun","year":"2018"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejso.2018.07.002"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1007\/s10549-018-4842-7"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2407-13-434"}],"container-title":["Cancer Research and Treatment"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/e-crt.org\/upload\/pdf\/crt-2023-386.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/e-crt.org\/journal\/view.php?doi=10.4143\/crt.2023.386","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/e-crt.org\/upload\/pdf\/crt-2023-386.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,11]],"date-time":"2024-01-11T07:39:23Z","timestamp":1704958763000},"score":1,"resource":{"primary":{"URL":"http:\/\/e-crt.org\/journal\/view.php?doi=10.4143\/crt.2023.386"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1,15]]},"references-count":29,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024,1]]}},"URL":"https:\/\/doi.org\/10.4143\/crt.2023.386","relation":{},"ISSN":["1598-2998","2005-9256"],"issn-type":[{"value":"1598-2998","type":"print"},{"value":"2005-9256","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,1,15]]},"assertion":[{"value":"2023-02-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-07-30","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-08-01","order":2,"name":"published","label":"Published online","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-01-15","order":3,"name":"published","label":"Print publication","group":{"name":"publication_history","label":"Publication History"}}]}}