{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T04:03:15Z","timestamp":1790827395376,"version":"4.1.0"},"reference-count":26,"publisher":"Korean Cancer Association","issue":"2","license":[{"start":{"date-parts":[[2023,10,12]],"date-time":"2023-10-12T00:00:00Z","timestamp":1697068800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":["e-crt.org"],"crossmark-restriction":true},"short-container-title":["Cancer Res Treat"],"published-print":{"date-parts":[[2024,4,15]]},"abstract":"<jats:p>Purpose Patients with advanced biliary tract cancer (BTC) have a poor survival. We aim to evaluate the efficacy and safety of nab-paclitaxel plus gemcitabine and cisplatin regimen in Chinese advanced BTC patients.Materials and Methods Eligible patients with locally advanced or metastatic BTC administrated intravenous 100 mg\/m&lt;sup&gt;2&lt;\/sup&gt; nab-paclitaxel, 800 mg\/m&lt;sup&gt;2&lt;\/sup&gt; gemcitabine, and 25 mg\/m&lt;sup&gt;2&lt;\/sup&gt; cisplatin every 3 weeks. The primary endpoint was progression-free survival (PFS). The secondary endpoints included overall survival (OS) and adverse events, while exploratory endpoint was the association of biomarkers with efficacy.Results After the median follow-up of 25.0 months, the median PFS and OS of 34 enrolled patients were 7.1 months (95% confidence interval [CI], 5.4 to 13.7) and 16.4 months (95% CI, 10.9 to 23.6), respectively. The most common treatment-related adverse events at \u2265 3 grade were neutropenia (26.5%) and leukopenia (26.5%). Survival analyses demonstrated that carcinoembryonic antigen (CEA) levels could monitor patients\u2019 survival outcomes. A significant increase in the number of infiltrating CD4+ cells (p=0.008) and a decrease in programmed death-1\u2013positive (PD-1+) cells (p=0.032) were observed in the response patients.Conclusion In advanced BTC patients, nab-paclitaxel plus gemcitabine and cisplatin regimen showed therapeutic potential. Potential prognostic factors of CEA levels, number of CD4+ cells and PD-1+ cells may help us maximize the efficacy benefit.<\/jats:p>","DOI":"10.4143\/crt.2023.726","type":"journal-article","created":{"date-parts":[[2023,10,12]],"date-time":"2023-10-12T01:11:54Z","timestamp":1697073114000},"page":"602-615","update-policy":"https:\/\/doi.org\/10.4143\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["A Single-Arm Phase II Study of Nab-Paclitaxel Plus Gemcitabine and Cisplatin for Locally Advanced or Metastatic Biliary Tract Cancer"],"prefix":"10.4143","volume":"56","author":[{"given":"Ting","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunhua","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Pu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shasha","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Lai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuebin","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisha","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuyang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miao","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongfeng","family":"Gou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2954","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(21)00153-7"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1038\/nrgastro.2016.51"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.2015-0446"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2014.01.021"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1056\/nejmoa0908721"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.10452"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2017.08.011"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdt540"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1007\/s00280-017-3353-2"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2019.0270"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.5009\/gnl210346"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.33476"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21660"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2018.3277"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-018-5211-y"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djz071"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0195118"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.2009.27819"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.113.071399"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1097\/mcg.0b013e318293a825"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-011-1976-9"},{"key":"ref22","first-page":"428","volume-title":"A population based analysis of prognostic factors in advanced biliary tract cancer","author":"Peixoto","year":"2014"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v20.i14.4085"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.4143\/crt.2016.538"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2017.401"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2013.610"}],"container-title":["Cancer Research and Treatment"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/e-crt.org\/upload\/pdf\/crt-2023-726.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/e-crt.org\/journal\/view.php?doi=10.4143\/crt.2023.726","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/e-crt.org\/upload\/pdf\/crt-2023-726.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,16]],"date-time":"2024-04-16T04:46:26Z","timestamp":1713242786000},"score":1,"resource":{"primary":{"URL":"http:\/\/e-crt.org\/journal\/view.php?doi=10.4143\/crt.2023.726"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4,15]]},"references-count":26,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2024,4]]}},"URL":"https:\/\/doi.org\/10.4143\/crt.2023.726","relation":{},"ISSN":["1598-2998","2005-9256"],"issn-type":[{"value":"1598-2998","type":"print"},{"value":"2005-9256","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,4,15]]},"assertion":[{"value":"2023-06-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication 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