{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T04:16:12Z","timestamp":1773116172583,"version":"3.50.1"},"reference-count":30,"publisher":"Korean Cancer Association","issue":"2","license":[{"start":{"date-parts":[[2023,10,6]],"date-time":"2023-10-06T00:00:00Z","timestamp":1696550400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":["e-crt.org"],"crossmark-restriction":true},"short-container-title":["Cancer Res Treat"],"published-print":{"date-parts":[[2024,4,15]]},"abstract":"<jats:p>Purpose The association of physical activity with the risk of bladder cancer remains inconsistent among Asian populations. We aimed to examine the association in a large Japanese cohort.Materials and Methods In a population-based prospective cohort study, a total of 50,374 Japanese adults aged 40-79 years without a history of cancer or cardiovascular disease who had information on physical activity from self-administrated questionnaires were used for analysis. We performed Cox proportional hazard models to estimate the hazard ratios (HRs) and 95% confidence intervals (CIs) for incident bladder cancer after adjusting for several potential confounders.Results During the median 17.5 years of follow-up, 153 incident bladder cancers (116 men and 37 women) were identified. After the multivariable adjustment, HRs (95% CI) of bladder cancer concerning those with recreational sports participation of 1-2 hr\/wk, 3-4 hr\/wk, and 5 hr\/wk and more were 0.67 (0.38-1.20), 0.79 (0.36-1.74), and 0.28 (0.09-0.89), respectively (p for trend=0.017). Compared with mostly sitting at the workplace, occupational physical activity of standing and walking were associated with a lower risk of bladder cancer (HR, 0.53 [95% CI, 0.32 to 0.85]). Hours of daily walking were not associated with the risk. The lower risk of bladder cancer was more evident for recreational sports (HR, 0.33 [95% CI, 0.10 to 1.00]), and for occupational standing and walking activity at work (HR, 0.57 [95% CI, 0.33 to 0.98]) among men.Conclusion Recreational sports participation and occupational physical activity were inversely associated with the risk of bladder cancer among Japanese, especially in men.<\/jats:p>","DOI":"10.4143\/crt.2023.962","type":"journal-article","created":{"date-parts":[[2023,10,6]],"date-time":"2023-10-06T01:11:22Z","timestamp":1696554682000},"page":"616-623","update-policy":"https:\/\/doi.org\/10.4143\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Physical Activity and Bladder Cancer Risk: Findings of the Japan Collaborative Cohort Study"],"prefix":"10.4143","volume":"56","author":[{"given":"Hang","family":"An","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keyang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kokoro","family":"Shirai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryo","family":"Kawasaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akiko","family":"Tamakoshi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroyasu","family":"Iso","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2954","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21492"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2016.06.010"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1586\/era.12.140"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.epi-06-0251"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.epi-13-0407"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1249\/mss.0000000000001937"},{"key":"ref7","first-page":"174","volume-title":"Physical 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production by human bladder tumor cell lines is up-regulated by bacillus Calmette-Guerin through nuclear factor-kappaB and Ap-1 via an immediate early pathway","author":"Chen","year":"2002"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2009.08.018"},{"key":"ref26","first-page":"271","volume-title":"Physical activity and cancer prevention : pathways and targets for intervention","author":"Rogers","year":"2008"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1016\/j.gendis.2020.10.002"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1016\/j.canep.2010.09.004"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6602473"},{"key":"ref30","first-page":"715","volume-title":"Epidemiology of bladder cancer deaths in Japan","author":"Ohno","year":"1977"}],"container-title":["Cancer Research and Treatment"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/e-crt.org\/upload\/pdf\/crt-2023-962.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/e-crt.org\/journal\/view.php?doi=10.4143\/crt.2023.962","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/e-crt.org\/upload\/pdf\/crt-2023-962.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,16]],"date-time":"2024-04-16T04:46:30Z","timestamp":1713242790000},"score":1,"resource":{"primary":{"URL":"http:\/\/e-crt.org\/journal\/view.php?doi=10.4143\/crt.2023.962"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4,15]]},"references-count":30,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2024,4]]}},"URL":"https:\/\/doi.org\/10.4143\/crt.2023.962","relation":{},"ISSN":["1598-2998","2005-9256"],"issn-type":[{"value":"1598-2998","type":"print"},{"value":"2005-9256","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,4,15]]},"assertion":[{"value":"2023-08-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication 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