{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T13:57:30Z","timestamp":1791640650176,"version":"4.3.4"},"reference-count":26,"publisher":"Korean Cancer Association","issue":"3","license":[{"start":{"date-parts":[[2024,12,16]],"date-time":"2024-12-16T00:00:00Z","timestamp":1734307200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"funder":[{"name":"Korean Cancer Study Group"},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["RS-2023-00249672"],"award-info":[{"award-number":["RS-2023-00249672"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100014188","name":"Ministry of Science and ICT","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100014188","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["e-crt.org"],"crossmark-restriction":true},"short-container-title":["Cancer Res Treat"],"published-print":{"date-parts":[[2025,7,15]]},"abstract":"<jats:p>Purpose The role of neoadjuvant chemotherapy in locally advanced sinonasal squamous cell carcinoma (SNSCC) has not been established prospectively. We conducted a phase II trial of neoadjuvant chemotherapy (NAC) with docetaxel\/cisplatin\/5-fluorouracil (TPF) in this population.Materials and Methods Eligible patients had unresectable, locally advanced SNSCC, defined as T3\/4 category or potential compromise of critical organ function on surgery. Three TPF (docetaxel 75 mg\/m2 and cisplatin 75 mg\/m2 on day 1, 5-fluorouracil 1,000 mg\/m2 on days 1-4 every 3 weeks) cycles were administered with prophylactic pegteograstim. The primary outcome was the objective response rate (ORR); the secondary outcomes included 2-year progression-free survival (PFS), eyeball preservation rate, and safety.Results Among 28 patients screened, 25 were evaluable for efficacy (one screen-failure; two evaluable for safety only). The confirmed ORR was 72.0%. The definitive post-NAC treatment comprised chemoradiotherapy (n=15) and surgery (n=10). With a median follow-up of 25.5 months, median PFS was not reached and the 2-year PFS rate was 60.4%. Response to NAC was related to prolonged PFS (p=0.038). No patient underwent eyeball exenteration at the data cutoff point. Treatment-related adverse events of grade \u2265 3 were neutropenia (48.1%) including febrile neutropenia (14.8%), followed by acute kidney injury (22.2%), nausea\/vomiting (11.1%), anemia (7.4%), thrombocytopenia (7.4%), and enterocolitis (3.7%).Conclusion TPF NAC showed a promising efficacy and might help preserve critical structures in this population, which needs to be validated in a large prospective trial (KCT0003377).<\/jats:p>","DOI":"10.4143\/crt.2024.1025","type":"journal-article","created":{"date-parts":[[2024,12,16]],"date-time":"2024-12-16T01:16:56Z","timestamp":1734311816000},"page":"701-708","update-policy":"https:\/\/doi.org\/10.4143\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Phase II Trial of Neoadjuvant Docetaxel\/Cisplatin\/5-Fluorouracil Combined with Pegteograstim for Unresectable, Locally Advanced Sinonasal Squamous Cell Carcinoma: KCSG HN18-07"],"prefix":"10.4143","volume":"57","author":[{"given":"Bhumsuk","family":"Keam","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ho Jung","family":"An","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seong Hoon","family":"Shin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min Kyoung","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jung 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and fluorouracil alone or with docetaxel in head and neck cancer","author":"Posner","year":"2007"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1056\/nejmoa071028"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1200\/jco.2023.41.16_suppl.6090"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1177\/01945998221083097"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.33452"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.3904\/kjim.2015.020"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/487872"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1001\/archoto.2010.231"},{"key":"ref17","first-page":"301","volume-title":"Neoadjuvant chemotherapy and radiation for inoperable carcinoma of the maxillary antrum: a matched-control study","author":"Kim","year":"2000"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2008.10.026"},{"key":"ref19","volume-title":"","author":"Edge","year":"2010"},{"key":"ref20","first-page":"E1305","volume-title":"Prognostic impact of pathological response to neoadjuvant chemotherapy followed by definitive surgery in sinonasal squamous cell carcinoma","author":"Hirakawa","year":"2016"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1056\/nejm199106133242402"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-015-2963-7"},{"key":"ref23","volume-title":"Hematopoietic growth factors (version 3.2024) [Internet]","year":"2024"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1111\/cas.12647"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-014-2270-8"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1111\/cas.14218"}],"container-title":["Cancer Research and Treatment"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/e-crt.org\/upload\/pdf\/crt-2024-1025.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/e-crt.org\/journal\/view.php?doi=10.4143\/crt.2024.1025","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/e-crt.org\/upload\/pdf\/crt-2024-1025.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,14]],"date-time":"2025-07-14T01:50:55Z","timestamp":1752457855000},"score":1,"resource":{"primary":{"URL":"http:\/\/e-crt.org\/journal\/view.php?doi=10.4143\/crt.2024.1025"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,15]]},"references-count":26,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,7]]}},"URL":"https:\/\/doi.org\/10.4143\/crt.2024.1025","relation":{},"ISSN":["1598-2998","2005-9256"],"issn-type":[{"value":"1598-2998","type":"print"},{"value":"2005-9256","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7,15]]},"assertion":[{"value":"2024-10-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication 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