{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T05:49:22Z","timestamp":1792043362677,"version":"4.4.0"},"reference-count":22,"publisher":"Korean Cancer Association","issue":"4","license":[{"start":{"date-parts":[[2025,9,17]],"date-time":"2025-09-17T00:00:00Z","timestamp":1758067200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100003710","name":"Korea Health Industry Development Institute","doi-asserted-by":"publisher","award":["HE23C002800"],"award-info":[{"award-number":["HE23C002800"]}],"id":[{"id":"10.13039\/501100003710","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003625","name":"Ministry of Health and Welfare","doi-asserted-by":"publisher","award":["HR20C0025"],"award-info":[{"award-number":["HR20C0025"]}],"id":[{"id":"10.13039\/501100003625","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003569","name":"Ministry of Food and Drug Safety","doi-asserted-by":"publisher","award":["RS-2024-00332632"],"award-info":[{"award-number":["RS-2024-00332632"]}],"id":[{"id":"10.13039\/501100003569","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["e-crt.org"],"crossmark-restriction":true},"short-container-title":["Cancer Res Treat"],"published-print":{"date-parts":[[2026,10,15]]},"abstract":"<jats:p>Purpose Axicabtagene ciloleucel (axi-cel), tisagenlecleucel (tisa-cel), and lisocabtagene maraleucel (liso-cel) have received regulatory approval for relapsed or refractory follicular lymphoma (FL). However, the data are scarce on their comparative effectiveness against the salvage therapies available in real-world settings. This study aimed to indirectly compare treatment outcomes of axi-cel, tisa-cel, and liso-cel versus usual care in South Korean patients with FL.Materials and Methods To assess effectiveness in real-world data, aggregate data from the ZUMA-5, ELARA, and TRANSCEND FL studies were compared with individual patient data from the Samsung Medical Center\u2013Lymphoma Cohort Study (SMC-LCS). Patients meeting ZUMA-5, ELARA, and TRANSCEND FL eligibility criteria were selected as the external control arm. All eligible treatment lines per patient were analyzed as independent episodes and weighted using the matching-adjusted indirect comparison method. Timeto-event outcomes were assessed with weighted Kaplan-Meier analysis, and adjusted hazard ratios (HRs) were estimated using Cox proportional hazards models.Results Axi-cel included 127 patients, tisa-cel included 94, liso-cel included 101, and 121 episodes from 49 patients were analyzed in the external control arm. The weighted HRs for overall survival and progression-free survival for axi-cel versus the external control were 0.37 (95% confidence interval [CI], 0.21 to 0.64) and 0.35 (95% CI, 0.20 to 0.59), respectively. For tisa-cel, the HRs were 0.24 (95% CI, 0.11 to 0.53), and 0.35 (95% CI, 0.20 to 0.60), respectively. For liso-cel, the HRs were 0.38 (95% CI, 0.13 to 1.04) and 0.36 (95% CI, 0.15 to 0.88), respectively.Conclusion All three chimeric antigen receptor T-cell therapies showed outstanding effectiveness compared to conventional treatments in usual care in South Korea.<\/jats:p>","DOI":"10.4143\/crt.2024.1181","type":"journal-article","created":{"date-parts":[[2025,9,17]],"date-time":"2025-09-17T02:17:34Z","timestamp":1758075454000},"page":"1449-1459","update-policy":"https:\/\/doi.org\/10.4143\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Effectiveness of CAR-T Cell Therapies for Relapsed\/Refractory Follicular Lymphoma: An External Control Arm Study"],"prefix":"10.4143","volume":"58","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-9182-7625","authenticated-orcid":true,"given":"Hee-Jin","family":"Seo","sequence":"first","affiliation":[{"name":"Department of Biohealth Regulatory Science, Sungkyunkwan University, Suwon, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7253-6515","authenticated-orcid":true,"given":"Ju Hwan","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Biohealth Regulatory Science, Sungkyunkwan University, Suwon, Korea"},{"name":"School of Pharmacy, Sungkyunkwan University, Suwon, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sang Eun","family":"Yoon","sequence":"additional","affiliation":[{"name":"Division of Hematology-Oncology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Won Seog","family":"Kim","sequence":"additional","affiliation":[{"name":"Division of Hematology-Oncology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong Keon","family":"Yon","sequence":"additional","affiliation":[{"name":"Center for Digital Health, Medical Science Research Institute, Kyung Hee University College of Medicine, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1010-7525","authenticated-orcid":true,"given":"Ju-Young","family":"Shin","sequence":"additional","affiliation":[{"name":"Department of Biohealth Regulatory Science, Sungkyunkwan University, Suwon, Korea"},{"name":"School of Pharmacy, Sungkyunkwan University, Suwon, Korea"},{"name":"Department of Clinical Research Design & Evaluation, Samsung Advanced Institute for Health Sciences and Technology, Sungkyunkwan University, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2776-4401","authenticated-orcid":true,"given":"Seok Jin","family":"Kim","sequence":"additional","affiliation":[{"name":"Division of Hematology-Oncology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea"},{"name":"Department of Health Sciences and Technology, Samsung Advanced Institute for Health Sciences and Technology, Sungkyunkwan University School of Medicine, Seoul, 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trends in lymphoid neoplasm distribution in South Korea: analysis of 8615 cases from a single institute, 1997-2016: an observational study","author":"Sim","year":"2019"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-019-0132-x","type":"journal-article"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1016\/j.clml.2015.12.012","type":"journal-article"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2022.281421","type":"journal-article"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.5045\/br.2022.2022037","type":"journal-article"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1177\/0272989x221096070","type":"journal-article"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1002\/pst.2107","type":"journal-article"}],"container-title":["Cancer Research and 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