{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T02:26:44Z","timestamp":1780885604320,"version":"3.54.1"},"reference-count":17,"publisher":"Korean Cancer Association","issue":"1","license":[{"start":{"date-parts":[[2025,4,15]],"date-time":"2025-04-15T00:00:00Z","timestamp":1744675200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"funder":[{"name":"Patient-Centered Clinical Research Coordinating Center"},{"DOI":"10.13039\/501100003625","name":"Ministry of Health and Welfare","doi-asserted-by":"publisher","award":["HC19C0110"],"award-info":[{"award-number":["HC19C0110"]}],"id":[{"id":"10.13039\/501100003625","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["e-crt.org"],"crossmark-restriction":true},"short-container-title":["Cancer Res Treat"],"published-print":{"date-parts":[[2026,1,15]]},"abstract":"<jats:p>PurposeSentinel lymph node biopsy (SLNB) using dye and isotope (DUAL) is recommended over the dye-only (DYE) method after neoadjuvant chemotherapy (NCT) due to potentially lower false-negative rates. However, the long-term outcome of either method is unclear. We aimed to compare the long-term oncological outcomes of DYE versus DUAL SLNB methods in patients who received NCT.Materials and MethodsIn this retrospective cohort study, 893 patients who underwent SLNB following NCT and had pathologically negative lymph nodes were included. After propensity score matching for cT, cN, and pT categories, 280 patients were in the DYE group and 560 in the DUAL group. Indigo carmine was used for dye and Tc-99m antimony trisulfate for isotope mapping.ResultsMedian follow-up was 75.6 months in the DYE group and 83.0 months in the DUAL group. Mean (\u00b1standard deviation) number of harvested sentinel nodes was 6.7 (\u00b13.9) and 6.7 (\u00b13.3) in the DYE and DUAL groups (p=0.875). Five-year distant metastasisfree survival was 95.2% in DYE group and 93.3% in DUAL group (hazard ratio [HR], 1.45; 95% confidence interval [CI], 0.82 to 2.57; p=0.192). Disease-free survival (HR, 0.97; 95% CI, 0.69 to 1.50; p=0.914) and overall survival (HR, 0.98; 95% CI, 0.56 to 1.69; p=0.954) were not significantly different. Axillary recurrence rate was 1.8% and 2.5% in DYE and DUAL groups (p=0.647).ConclusionLong-term oncological outcomes did not significantly differ between DYE and DUAL SLNB methods. The dye-only method can be safely recommended for breast cancer patients who received NCT.<\/jats:p>","DOI":"10.4143\/crt.2024.1253","type":"journal-article","created":{"date-parts":[[2025,4,15]],"date-time":"2025-04-15T00:32:25Z","timestamp":1744677145000},"page":"175-181","update-policy":"https:\/\/doi.org\/10.4143\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Comparison of Long-term Oncological Outcome of Sentinel Lymph Node Mapping Methods (Dye-Only versus Dye and Radioisotope) in Breast Cancer Patients Following Neoadjuvant Chemotherapy"],"prefix":"10.4143","volume":"58","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-7615-7698","authenticated-orcid":true,"given":"Jinyoung","family":"Byeon","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changjin","family":"Lim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eunhye","family":"Kang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji-Jung","family":"Jung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong-Kyu","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han-Byoel","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyeong-Gon","family":"Moon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7310-0764","authenticated-orcid":true,"given":"Wonshik","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2954","reference":[{"key":"ref1","first-page":"586","volume-title":"Axillary dissection in breast-conserving surgery for stage I and II breast cancer: a National Cancer Data Base study of patterns of omission and implications for survival","author":"Bland","year":"1999"},{"key":"ref2","first-page":"3657","volume-title":"Surgical complications associated with sentinel lymph node dissection (SLND) plus axillary lymph node dissection compared with SLND alone in the American College of Surgeons Oncology Group Trial Z0011","author":"Lucci","year":"2007"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1007\/s10549-005-9025-7"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2007.07.2376"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/s1470-2045(13)70590-4"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1007\/s00268-012-1623-z"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.4143\/crt.2022.871"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1200\/jco.2014.55.7827"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1200\/jco.2015.64.0094"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1097\/sla.0b013e3181b8fd5e"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/s1470-2045(13)70166-9"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1200\/jco.2014.57.8401"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2013.278932"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1007\/bf02966726"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.10986"},{"key":"ref16","volume-title":"","year":"2025"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1200\/jco.2014.32.15_suppl.tps1141"}],"container-title":["Cancer Research and Treatment"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/e-crt.org\/upload\/pdf\/crt-2024-1253.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/e-crt.org\/journal\/view.php?doi=10.4143\/crt.2024.1253","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/e-crt.org\/upload\/pdf\/crt-2024-1253.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,12]],"date-time":"2026-01-12T07:44:38Z","timestamp":1768203878000},"score":1,"resource":{"primary":{"URL":"http:\/\/e-crt.org\/journal\/view.php?doi=10.4143\/crt.2024.1253"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,15]]},"references-count":17,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"URL":"https:\/\/doi.org\/10.4143\/crt.2024.1253","relation":{},"ISSN":["1598-2998","2005-9256"],"issn-type":[{"value":"1598-2998","type":"print"},{"value":"2005-9256","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,15]]},"assertion":[{"value":"2024-12-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication 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