{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T21:45:37Z","timestamp":1760132737305,"version":"3.32.0"},"reference-count":21,"publisher":"Korean Cancer Association","issue":"1","license":[{"start":{"date-parts":[[2024,7,23]],"date-time":"2024-07-23T00:00:00Z","timestamp":1721692800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":["e-crt.org"],"crossmark-restriction":true},"short-container-title":["Cancer Res Treat"],"published-print":{"date-parts":[[2025,1,15]]},"abstract":"<jats:p>PurposeThis study investigated the recurrence patterns and timing in patients with pathologic N2 (pN2) non-small cell lung cancer (NSCLC) according to the residual tumor (R) descriptor proposed by the International Association for the Study of Lung Cancer (IASLC).Materials and MethodsFrom 2004 to 2021, patients with pN2 NSCLC who underwent anatomical resection were analyzed according to the IASLC R criteria using medical records from a single center. Survival analysis was performed using Cox proportional hazards models. Recurrence patterns between complete (R0) and uncertain resections (R[un]) were compared.ResultsIn total, 1,373 patients were enrolled in this study: 576 (42.0%) in R0, 286 (20.8%) in R(un), and 511 (37.2%) in R1\/R2 according to the IASLC R criteria. The most common reason for R(un) classification was positivity for the highest lymph node (88.8%). In multivariable analysis, the hazard ratios for recurrence in R(un) and R1\/R2 compared to R0 were 1.18 (95% confidence interval [CI], 0.96\u20131.46) and 1.58 (1.31\u20131.90), respectively. The hazard rate curves displayed similar patterns among groups, peaking at approximately 12 months after surgery. There was a significant difference in distant recurrence patterns between R0 and R(un). Further analysis after stratification with the IASLC N2 descriptor showed significant differences in distant recurrence patterns between R0 and R(un) in patients pN2a1 and pN2a2 disease, but not in those with pN2b disease.ConclusionThe IASLC R criteria has prognostic relevance in patients with pN2 NSCLC. R(un) is a highly heterogeneous group, and the involvement of the highest mediastinal lymph node can affect distant recurrence patterns.<\/jats:p>","DOI":"10.4143\/crt.2024.150","type":"journal-article","created":{"date-parts":[[2024,7,26]],"date-time":"2024-07-26T02:24:11Z","timestamp":1721960651000},"page":"105-115","update-policy":"https:\/\/doi.org\/10.4143\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Recurrence Dynamics of Pathological N2 Non\u2013Small Cell Lung Cancer Based on IASLC Residual Tumor Descriptor"],"prefix":"10.4143","volume":"57","author":[{"given":"In Ha","family":"Kim","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Geun Dong","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sehoon","family":"Choi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyeong 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proposals for the revision of the N descriptors in the forthcoming 8th edition of the TNM classification for lung cancer","author":"Asamura","year":"2015"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016\/s0022-5223(19)40289-4"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1200\/jco.2018.78.7101"},{"key":"ref19","first-page":"766","volume-title":"The International Association for the Study of Lung Cancer Staging Project for Lung Cancer: proposals for the revision of the N descriptors in the forthcoming ninth edition of the TNM classification for lung cancer","author":"Huang","year":"2024"},{"key":"ref20","first-page":"437","volume-title":"Normativa actualizada (1998) sobre diagn\u00f3stico y estadificaci\u00f3n del carcinoma broncog\u00e9nico [Updated regulations (1998) on diagnosis and staging of bronchogenic carcinoma]","author":"Porta","year":"1998"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1016\/j.lungcan.2019.09.018"}],"container-title":["Cancer 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