{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T03:19:37Z","timestamp":1768274377414,"version":"3.49.0"},"reference-count":31,"publisher":"Korean Cancer Association","issue":"1","license":[{"start":{"date-parts":[[2024,7,3]],"date-time":"2024-07-03T00:00:00Z","timestamp":1719964800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100002635","name":"Inha University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002635","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["2018R1C1B5086265"],"award-info":[{"award-number":["2018R1C1B5086265"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100014188","name":"Ministry of Science and ICT","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100014188","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["e-crt.org"],"crossmark-restriction":true},"short-container-title":["Cancer Res Treat"],"published-print":{"date-parts":[[2025,1,15]]},"abstract":"<jats:p>Purpose Stereotactic radiosurgery (SRS) or fractionated stereotactic radiotherapy (FSRT) are increasingly used as initial therapies for brain metastases (BM). We aimed to assess the outcomes of SRS\/FSRT in patients aged \u2265 65 years who had 1-10 BM from non\u2013small cell lung cancer (NSCLC).Materials and Methods We retrospectively reviewed 91 elderly NSCLC patients with 222 BM who were treated with SRS\/FSRT at two institutions between 2010 and 2020. The primary endpoint was overall survival (OS) after SRS\/FSRT. In addition, in-field local control (IFLC) within the treated field was evaluated. Statistical analysis was performed to identify the prognostic factors affecting OS and IFLC.Results During a median follow-up of 18 months, the median OS was 32 months. The 1- and 2-year survival rates were 69.8% and 56.1%, respectively. In multivariate analysis, the NSCLC-specific graded prognostic assessment (GPA) score (p=0.007) and administration of systemic therapy (p=0.039) were defined as prognosticators affecting OS. The median IFLC period was 31 months, and the 1- and 2-year IFLC rates were 75.9% and 57.6%, respectively. The total BM volume (p=0.042) significantly affected IFLC. No severe adverse events were reported after SRS\/FSRT.Conclusion SRS\/FSRT is an effective upfront treatment option for BM arising from NSCLC in elderly patients, with a good OS without severe side effects. Higher GPA score and active systemic treatment were associated with improved OS, indicating that elderly patients are significant candidates for SRS\/FSRT.<\/jats:p>","DOI":"10.4143\/crt.2024.223","type":"journal-article","created":{"date-parts":[[2024,7,4]],"date-time":"2024-07-04T02:41:08Z","timestamp":1720060868000},"page":"47-56","update-policy":"https:\/\/doi.org\/10.4143\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Upfront Stereotactic Radiosurgery or Fractionated Stereotactic Radiotherapy in Elderly Patients with Brain Metastases from Non\u2013Small Cell Lung Cancer: A Retrospective Analysis of a 10-Year Bi-institutional Experience"],"prefix":"10.4143","volume":"57","author":[{"given":"Myungsoo","family":"Kim","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jihye","family":"Cha","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hun 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adults","author":"Zamudio-Rodriguez","year":"2021"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1007\/s11060-019-03242-8"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1016\/j.lungcan.2020.07.037"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1016\/j.cllc.2017.06.011"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1007\/s13402-017-0345-5"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21041416"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1016\/s1470-2045(20)30111-x"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1007\/s11060-012-1016-z"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2005.04.037"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2005.08.035"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-016-2983-9"}],"container-title":["Cancer Research and 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