{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T13:43:37Z","timestamp":1783691017920,"version":"3.55.0"},"reference-count":33,"publisher":"Korean Cancer Association","issue":"2","license":[{"start":{"date-parts":[[2024,10,4]],"date-time":"2024-10-04T00:00:00Z","timestamp":1728000000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":["e-crt.org"],"crossmark-restriction":true},"short-container-title":["Cancer Res Treat"],"published-print":{"date-parts":[[2025,4,15]]},"abstract":"<jats:p>Purpose This study aimed to evaluate long-term treatment outcomes in patients with localized gastric mucosa-associated lymphoid tissue (MALT) lymphoma treated with radiotherapy (RT).Materials and Methods A total of 229 patients who received RT in 10 tertiary hospitals between 2010 and 2019 were included in this multicenter analysis. Response after RT was based on esophagogastroduodenoscopy after RT. Locoregional relapse-free survival (LRFS) and disease-free survival (DFS), and overall survival (OS) were evaluated.Results After a median follow-up time of 93.2 months, 5-year LRFS, DFS, and OS rates were 92.8%, 90.4%, and 96.1%, respectively. LRFS, DFS, and OS rates at 10 years were 90.3%, 87.7%, and 92.8%, respectively. Of 229 patients, 228 patients (99.6%) achieved complete remission after RT. Five-year LRFS was significantly lower in patients with stage IIE than in those with stage IE (77.4% vs. 94.2%, p=0.047). Patients with age \u2265 60 had significantly lower LRFS than patients with age &lt; 60 (89.3% vs. 95.1%, p=0.003). In the multivariate analysis, old age (\u2265 60 years) was a poor prognostic factor for LRFS (hazard ratio, 3.72; confidence interval, 1.38 to 10.03; p=0.009). Grade 2 or higher gastritis was reported in 69 patients (30.1%). Secondary malignancies including gastric adenocarcinoma, malignant lymphoma, lung cancer, breast cancer, and prostate cancer were observed in 11 patients (4.8%) after RT.Conclusion Patients treated with RT for localized gastric MALT lymphoma showed favorable 10-year outcomes. Radiation therapy is an effective treatment without an increased risk of secondary cancer. The toxicity for RT to the stomach is not high.<\/jats:p>","DOI":"10.4143\/crt.2024.651","type":"journal-article","created":{"date-parts":[[2024,10,4]],"date-time":"2024-10-04T02:33:07Z","timestamp":1728009187000},"page":"570-579","update-policy":"https:\/\/doi.org\/10.4143\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Long-term Clinical Efficacy of Radiotherapy for Patients with Stage I-II Gastric Extranodal Marginal Zone B-Cell Lymphoma of Mucosa-Associated Lymphoid Tissue: A Retrospective Multi-institutional Study"],"prefix":"10.4143","volume":"57","author":[{"given":"Jae Uk","family":"Jeong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyo Chun","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin Ho","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keun Yong","family":"Eom","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin Hee","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoo Kang","family":"Kwak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Woo Chul","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sun Young","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin Hwa","family":"Choi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kang Kyu","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jong Hoon","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2954","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.3960\/jslrt.47.31"},{"key":"ref2","first-page":"3909","volume-title":"The Non-Hodgkin\u2019s Lymphoma Classification Project","year":"1997"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.3390\/jcm12010120"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(93)91409-f"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdl468"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.25226"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-013-0844-8"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1200\/jco.2013.54.8800"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.14153"},{"key":"ref10","volume-title":"Common Terminology Criteria for Adverse Events (CTCAE) version 5.0 [Internet]","year":"2017"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1200\/jco.2005.02.3903"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2008.02.012"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-018-1517-4"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1002\/hon.3078"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mds623"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.5009\/gnl15510"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2017-03-771915"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.3857\/roj.2023.00339"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2019.02.002"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2021.681689"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mds644"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2011-300495"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1200\/jco.2005.04.2200"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1023\/a:1008328226599"},{"key":"ref25","first-page":"1481","volume-title":"Risk of second cancer after treatment of aggressive non-Hodgkin\u2019s lymphoma; 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