{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T05:49:20Z","timestamp":1792043360616,"version":"4.4.0"},"reference-count":27,"publisher":"Korean Cancer Association","issue":"4","license":[{"start":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T00:00:00Z","timestamp":1756252800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"funder":[{"name":"Patient-Centered Clinical Research Coordinating Center","id":[{"id":"https:\/\/ror.org\/00fzvsb30","id-type":"ROR","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100003625","name":"Ministry of Health and Welfare","doi-asserted-by":"publisher","award":["RS-2020-KH094340"],"award-info":[{"award-number":["RS-2020-KH094340"]}],"id":[{"id":"10.13039\/501100003625","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["e-crt.org"],"crossmark-restriction":true},"short-container-title":["Cancer Res Treat"],"published-print":{"date-parts":[[2026,10,15]]},"abstract":"<jats:p>Purpose This study investigated the impact of pre-admission central nervous system (CNS) medication use on delirium incidence, duration, and survival in hospitalized patients with advanced cancer.Materials and Methods In this multicenter prospective study across four tertiary hospitals in South Korea, adults with advanced cancer were enrolled and categorized based on their use of CNS medications within 90 days preceding admission. Associations between pre-admission CNS medication use and outcomes (delirium incidence, delirium duration, and overall survival) were assessed using multivariable regression and Cox proportional hazards models.Results Of the 190 patients enrolled, 140 had used CNS medications prior to admission. Delirium occurred in 22.1% of the patients with CNS medication use versus 14.0% of those without (adjusted odds ratio [aOR], 2.53; 95% confidence interval [CI], 0.95 to 7.60; not significant). Opioid (aOR, 2.48; 95% CI, 1.01 to 6.61) and antidepressant (aOR, 5.58; 95% CI, 1.22 to 27.35) use were significantly associated with increased delirium risk. Use of three or more CNS medication classes was associated with a markedly high risk (aOR, 11.15; 95% CI, 2.13 to 64.17). Delirium duration did not differ significantly between groups. Patients with pre-admission CNS medication exposure exhibited shorter overall survival (adjusted hazard ratio [aHR], 1.45; 95% CI, 1.01 to 2.09). Prior opioid use was also associated with increased mortality (aHR, 1.45; 95% CI, 1.03 to 2.05).Conclusion Pre-admission exposure to CNS medication, particularly opioids and antidepressants, was associated with an increased risk of delirium in patients with advanced cancer. A thorough medication history review upon admission is crucial to identifying high-risk patients and implementing early preventive interventions.<\/jats:p>","DOI":"10.4143\/crt.2025.460","type":"journal-article","created":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T07:41:37Z","timestamp":1756280497000},"page":"1508-1516","update-policy":"https:\/\/doi.org\/10.4143\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Impact of Pre-admission Central Nervous System Medication Use on Delirium in Hospitalized Patients with Advanced Cancer: A Multicenter, Prospective, Observational Study in Korea"],"prefix":"10.4143","volume":"58","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8493-4078","authenticated-orcid":true,"given":"Min Jung","family":"Geum","sequence":"first","affiliation":[{"name":"Department of Pharmacy, Severance Hospital, Yonsei University Health System, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shin Hye","family":"Yoo","sequence":"additional","affiliation":[{"name":"Center for Palliative Care and Clinical Ethics, Seoul National University Hospital, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Si Won","family":"Lee","sequence":"additional","affiliation":[{"name":"Division of Medical Oncology, Department of Internal Medicine, Eunpyeong St. Mary\u2019s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moonki","family":"Hong","sequence":"additional","affiliation":[{"name":"Division of Hemato-Oncology, Department of Internal Medicine, Yongin Severance Hospital, Yonsei University College of Medicine, Yongin, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eun Hee","family":"Jung","sequence":"additional","affiliation":[{"name":"Division of Hematology and Medical Oncology, Department of Internal Medicine, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu Jung","family":"Kim","sequence":"additional","affiliation":[{"name":"Division of Hematology and Medical Oncology, Department of Internal Medicine, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5177-8937","authenticated-orcid":true,"given":"Beodeul","family":"Kang","sequence":"additional","affiliation":[{"name":"Division of Medical Oncology, Department of Internal Medicine, CHA Bundang Medical Center, CHA University School of Medicine, Seongnam, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2954","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1038\/nrclinonc.2014.147","type":"journal-article"},{"key":"ref2","volume-title":"","type":"book"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1155\/2011\/875196","type":"journal-article"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2020.11.011","type":"journal-article"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdy147","type":"journal-article"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejcsup.2013.07.008","type":"journal-article"},{"key":"ref7","volume-title":"","type":"book"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1111\/jgs.14076","type":"journal-article"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1200\/jco.2005.05.140","type":"journal-article"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1093\/ageing\/afq140","type":"journal-article"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1177\/1941874413493185","type":"journal-article"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2019.05.035","type":"journal-article"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2016.03.003","type":"journal-article"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics15010230","type":"journal-article"},{"key":"ref15","first-page":"25","type":"journal-article","volume-title":"Insight 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