{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T05:49:15Z","timestamp":1792043355269,"version":"4.4.0"},"reference-count":71,"publisher":"Korean Cancer Association","issue":"4","license":[{"start":{"date-parts":[[2025,10,2]],"date-time":"2025-10-02T00:00:00Z","timestamp":1759363200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":["e-crt.org"],"crossmark-restriction":true},"short-container-title":["Cancer Res Treat"],"published-print":{"date-parts":[[2026,10,15]]},"abstract":"<jats:p>Purpose Exercise can enhance the therapeutic effects of adjuvant medications, improve both physiological and psychological functions, and increase physical fitness among breast cancer patients receiving adjuvant therapy. This systematic review and meta-analysis examined the latest research on the effects of exercise interventions in this population. Furthermore, subgroup analyses were performed based on exercise type, intensity, frequency, duration, and types of adjuvant therapy.Materials and Methods The PubMed, Embase, CINAHL, and CENTRAL databases were systematically searched from inception to April 2024 to identify randomized controlled trials (RCTs) examining the use of exercise interventions among breast cancer patients receiving adjuvant therapy. The data extracted from the included studies were analyzed via RevMan 5.4.Results A total of 34 studies involving 2,696 participants were included, with 1,369 in the intervention group and 1,327 in the control group, and a mean age ranging from 40 to 60 years. Compared to the control group, exercise interventions improved fatigue, muscular strength, cardiorespiratory fitness, inflammation, and quality of life in breast cancer patients (fatigue: standardized mean difference [SMD]=\u20130.29; 95% confidence interval [CI], \u20130.50 to \u20130.09; p=0.005; upper limb strength: SMD=0.50; 95% CI, 0.33 to 0.68; p &lt; 0.001, lower limb strength: SMD=0.37; 95% CI, 0.22 to 0.52; p &lt; 0.001; cardiorespiratory fitness: SMD=0.51; 95% CI, 0.26 to 0.75; p &lt; 0.001; inflammation: SMD=\u20130.36; 95% CI, \u20130.66 to \u20130.06; p=0.02; quality of life: SMD=0.21; 95% CI, 0.11 to 0.31; p &lt; 0.001). Moderate effect sizes were observed for the alleviation of anxiety and depressive symptoms, although these results did not reach statistical significance (depression: SMD=\u20130.13; 95% CI, \u20130.28 to 0.02; p=0.08; anxiety: SMD=\u20130.81; 95% CI, \u20131.65 to 0.03; p=0.06).Conclusion Exercise during adjuvant therapy can reduce the side effects of adjuvant medications, improve both physiological and psychological functions, and enhance physical fitness among patients with breast cancer.<\/jats:p>","DOI":"10.4143\/crt.2025.762","type":"journal-article","created":{"date-parts":[[2025,10,2]],"date-time":"2025-10-02T05:14:20Z","timestamp":1759382060000},"page":"1245-1272","update-policy":"https:\/\/doi.org\/10.4143\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Effects of Exercise Interventions on Breast Cancer Patients during Adjuvant Therapy: A Systematic Review and Meta-Analysis"],"prefix":"10.4143","volume":"58","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1438-9999","authenticated-orcid":true,"given":"Zhiyuan","family":"Sun","sequence":"first","affiliation":[{"name":"Shandong Sports Science Research Institute, Shandong Sport University, Jinan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-1820-1980","authenticated-orcid":true,"given":"Tengteng","family":"Han","sequence":"additional","affiliation":[{"name":"Shandong Sports Science Research Institute, Shandong Sport University, Jinan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lianshi","family":"Feng","sequence":"additional","affiliation":[{"name":"Shandong Sports Science Research Institute, Shandong Sport University, Jinan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dewei","family":"Mao","sequence":"additional","affiliation":[{"name":"Division of Physical Education, The Chinese University of Hong Kong (Shenzhen Campus), Shenzhen,  China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Can","family":"Zhao","sequence":"additional","affiliation":[{"name":"School of Athletic Performance, Shanghai University of Sport, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-6895-579X","authenticated-orcid":true,"given":"Jie","family":"Han","sequence":"additional","affiliation":[{"name":"Shandong Sports Science Research Institute, Shandong Sport University, Jinan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-7614-9479","authenticated-orcid":true,"given":"Qinghui","family":"Shang","sequence":"additional","affiliation":[{"name":"Shandong Sports Science Research Institute, Shandong Sport University, Jinan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2954","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21660","type":"journal-article"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/j.breast.2022.08.010","type":"journal-article"},{"key":"ref3","first-page":"600","type":"book","volume-title":"","author":"Wright","year":"2010"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctrv.2022.102375","type":"journal-article"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2023.1222947","type":"journal-article"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1007\/s12282-022-01347-z","type":"journal-article"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1249\/mss.0000000000002116","type":"journal-article"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.breast.2017.04.003","type":"journal-article"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.f6715","type":"journal-article"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1200\/jco.2014.59.1081","type":"journal-article"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.rehab.2021.101485","type":"journal-article"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1007\/s10549-019-05204-0","type":"journal-article"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.12965\/jer.1735048.524","type":"journal-article"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1519\/jsc.0000000000003990","type":"journal-article"},{"key":"ref15","first-page":"223","type":"journal-article","volume-title":"Effects of home-based exercise training on VO2 in breast cancer patients under adjuvant or neoadjuvant chemotherapy (SAPA): a randomized controlled trial","author":"Cornette","year":"2016"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1200\/jco.2006.08.2024","type":"journal-article"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016\/j.jshs.2023.07.001","type":"journal-article"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1097\/01893697-200523010-00004","type":"journal-article"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1188\/07.onf.627-633","type":"journal-article"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1007\/s10549-012-2331-y","type":"journal-article"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1188\/13.onf.e374-e381","type":"journal-article"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1111\/sms.12777","type":"journal-article"},{"key":"ref23","first-page":"5623","type":"journal-article","volume-title":"Comparing endurance and resistance training with standard care during chemotherapy for patients with primary breast cancer","author":"Schmidt","year":"2015"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdu374","type":"journal-article"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.29383","type":"journal-article"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-015-2884-5","type":"journal-article"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1007\/s12160-011-9324-7","type":"journal-article"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.30938","type":"journal-article"},{"key":"ref29","first-page":"155","type":"journal-article","volume-title":"The effect of yoga exercise on improving depression, anxiety, and fatigue in women with breast cancer: a randomized controlled trial","author":"Taso","year":"2014"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1200\/jco.2012.48.2752","type":"journal-article"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.1007\/s10549-017-4571-3","type":"journal-article"},{"key":"ref32","first-page":"130","type":"journal-article","volume-title":"The psychological and physical benefits of the supervised individual exercise program during radiotherapy in breast cancer patients: a randomized prospective study","author":"Ozkan","year":"2022"},{"key":"ref33","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.27904","type":"journal-article"},{"key":"ref34","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.30172","type":"journal-article"},{"key":"ref35","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijnurstu.2022.104317","type":"journal-article"},{"key":"ref36","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.2017-0174","type":"journal-article"},{"key":"ref37","doi-asserted-by":"publisher","DOI":"10.1007\/s10549-015-3541-x","type":"journal-article"},{"key":"ref38","doi-asserted-by":"publisher","DOI":"10.1002\/pon.1525","type":"journal-article"},{"key":"ref39","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2016-012187","type":"journal-article"},{"key":"ref40","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpainsymman.2015.12.332","type":"journal-article"},{"key":"ref41","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2015.10.058","type":"journal-article"},{"key":"ref42","doi-asserted-by":"publisher","DOI":"10.1249\/mss.0000000000002490","type":"journal-article"},{"key":"ref43","doi-asserted-by":"publisher","DOI":"10.1001\/jamainternmed.2018.3915","type":"journal-article"},{"key":"ref44","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-015-1213-1","type":"journal-article"},{"key":"ref45","doi-asserted-by":"publisher","DOI":"10.1186\/s13063-019-3499-9","type":"journal-article"},{"key":"ref46","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djt297","type":"journal-article"},{"key":"ref47","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2024.1341927","type":"journal-article"},{"key":"ref48","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijnss.2020.03.001","type":"journal-article"},{"key":"ref49","doi-asserted-by":"publisher","DOI":"10.1016\/j.pmrj.2010.03.024","type":"journal-article"},{"key":"ref50","doi-asserted-by":"publisher","DOI":"10.3390\/ijms25147533","type":"journal-article"},{"key":"ref51","first-page":"395","type":"book","volume-title":"","author":"Fu","year":"2019"},{"key":"ref52","doi-asserted-by":"publisher","DOI":"10.1097\/01.coc.0000190459.14841.55","type":"journal-article"},{"key":"ref53","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijnurstu.2024.104990","type":"journal-article"},{"key":"ref54","doi-asserted-by":"publisher","DOI":"10.1002\/jcsm.12165","type":"journal-article"},{"key":"ref55","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.27917","type":"journal-article"},{"key":"ref56","doi-asserted-by":"publisher","DOI":"10.1590\/s1806-37562017000000120","type":"journal-article"},{"key":"ref57","doi-asserted-by":"publisher","DOI":"10.1016\/j.breast.2017.02.002","type":"journal-article"},{"key":"ref58","doi-asserted-by":"publisher","DOI":"10.1007\/s10549-024-07559-5","type":"journal-article"},{"key":"ref59","first-page":"e14652","type":"journal-article","volume-title":"High-intensity interval training and cardiorespiratory fitness in adults: an umbrella review of systematic reviews and meta-analyses","author":"Poon","year":"2024"},{"key":"ref60","doi-asserted-by":"publisher","DOI":"10.1200\/jco.2022.40.16_suppl.e18696","type":"journal-article"},{"key":"ref61","doi-asserted-by":"publisher","DOI":"10.1002\/pon.6370","type":"journal-article"},{"key":"ref62","doi-asserted-by":"publisher","DOI":"10.1530\/erc-20-0507","type":"journal-article"},{"key":"ref63","doi-asserted-by":"publisher","DOI":"10.1177\/1178223417743976","type":"journal-article"},{"key":"ref64","doi-asserted-by":"publisher","DOI":"10.1158\/1940-6207.capr-12-0278","type":"journal-article"},{"key":"ref65","doi-asserted-by":"publisher","DOI":"10.1016\/j.anr.2023.11.001","type":"journal-article"},{"key":"ref66","doi-asserted-by":"publisher","DOI":"10.5114\/pq.2019.87737","type":"journal-article"},{"key":"ref67","doi-asserted-by":"publisher","DOI":"10.1002\/cam4.70671","type":"journal-article"},{"key":"ref68","doi-asserted-by":"publisher","DOI":"10.1097\/ncc.0000000000000682","type":"journal-article"},{"key":"ref69","doi-asserted-by":"publisher","DOI":"10.1002\/cam4.6387","type":"journal-article"},{"key":"ref70","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph18137201","type":"journal-article"},{"key":"ref71","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-024-83846-x","type":"journal-article"}],"container-title":["Cancer Research and Treatment"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/e-crt.org\/upload\/pdf\/crt-2025-762.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/e-crt.org\/journal\/view.php?doi=10.4143\/crt.2025.762","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/e-crt.org\/upload\/pdf\/crt-2025-762.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T05:36:33Z","timestamp":1792042593000},"score":1,"resource":{"primary":{"URL":"http:\/\/e-crt.org\/journal\/view.php?doi=10.4143\/crt.2025.762"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,15]]},"references-count":71,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,10]]}},"URL":"https:\/\/doi.org\/10.4143\/crt.2025.762","relation":{},"ISSN":["1598-2998","2005-9256"],"issn-type":[{"value":"1598-2998","type":"print"},{"value":"2005-9256","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,15]]},"assertion":[{"value":"2025-07-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-09-28","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-10-02","order":2,"name":"published","label":"Published online","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-10-15","order":3,"name":"published","label":"Print publication","group":{"name":"publication_history","label":"Publication History"}}]}}