{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T05:23:49Z","timestamp":1781241829380,"version":"3.54.1"},"reference-count":29,"publisher":"Informa UK Limited","issue":"1","content-domain":{"domain":["www.tandfonline.com"],"crossmark-restriction":true},"short-container-title":["Bioanalysis"],"published-print":{"date-parts":[[2019,1]]},"DOI":"10.4155\/bio-2018-0236","type":"journal-article","created":{"date-parts":[[2018,12,10]],"date-time":"2018-12-10T16:00:02Z","timestamp":1544457602000},"page":"21-32","update-policy":"https:\/\/doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":4,"title":["Juvenile Rat and Pediatric Trazodone Studies: How to Gain Extra Sensitivity to Overcome Bioanalytical Challenges"],"prefix":"10.1080","volume":"11","author":[{"given":"Silvana","family":"Olivieri","sequence":"first","affiliation":[{"name":"Angelini RR&D (Research, Regulatory & Development), Angelini SpA, Piazzale della Stazione snc, 00071 \u2013 S Palomba-Pomezia(Rome), Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Graziella","family":"Bovi","sequence":"additional","affiliation":[{"name":"Angelini RR&D (Research, Regulatory & Development), Angelini SpA, Piazzale della Stazione snc, 00071 \u2013 S Palomba-Pomezia(Rome), Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vanessa","family":"Petrucci","sequence":"additional","affiliation":[{"name":"Angelini RR&D (Research, Regulatory & Development), Angelini SpA, Piazzale della Stazione snc, 00071 \u2013 S Palomba-Pomezia(Rome), Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Alfieri","sequence":"additional","affiliation":[{"name":"Angelini RR&D (Research, Regulatory & Development), Angelini SpA, Piazzale della Stazione snc, 00071 \u2013 S Palomba-Pomezia(Rome), Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Oggianu","sequence":"additional","affiliation":[{"name":"Angelini RR&D (Research, Regulatory & Development), Angelini SpA, Piazzale della Stazione snc, 00071 \u2013 S Palomba-Pomezia(Rome), Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rossella","family":"Picollo","sequence":"additional","affiliation":[{"name":"Angelini RR&D (Research, Regulatory & Development), Angelini SpA, Piazzale della Stazione snc, 00071 \u2013 S Palomba-Pomezia(Rome), Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolina","family":"Devastato","sequence":"additional","affiliation":[{"name":"Angelini RR&D (Research, Regulatory & Development), Angelini SpA, Piazzale della Stazione snc, 00071 \u2013 S Palomba-Pomezia(Rome), Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrizia","family":"Dragone","sequence":"additional","affiliation":[{"name":"Angelini RR&D (Research, Regulatory & Development), Angelini SpA, Piazzale della Stazione snc, 00071 \u2013 S Palomba-Pomezia(Rome), Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabio","family":"Garofolo","sequence":"additional","affiliation":[{"name":"Angelini RR&D (Research, Regulatory & Development), Angelini SpA, Piazzale della Stazione snc, 00071 \u2013 S Palomba-Pomezia(Rome), Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Serena","family":"Tongiani","sequence":"additional","affiliation":[{"name":"Angelini RR&D (Research, Regulatory & Development), Angelini SpA, Piazzale della Stazione snc, 00071 \u2013 S Palomba-Pomezia(Rome), Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2018,12,10]]},"reference":[{"key":"e_1_3_3_2_1","unstructured":"Palazzo G SilvestriniB : CA:69 52146W (1968)."},{"key":"e_1_3_3_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpp.12812"},{"key":"e_1_3_3_4_1","doi-asserted-by":"publisher","DOI":"10.1177\/0269881105051526"},{"key":"e_1_3_3_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinbiochem.2016.06.014"},{"key":"e_1_3_3_6_1","doi-asserted-by":"publisher","DOI":"10.2174\/1381612821666150619092236"},{"issue":"7","key":"e_1_3_3_7_1","first-page":"24","article-title":"Trazodone for insomnia: a systematic review","volume":"14","author":"Jaffer KY","year":"2017","unstructured":"Jaffer KY , ChangT, VanleBet al. Trazodone for insomnia: a systematic review. Innov. Clin. Neurosci.14 (7\u20138), 24\u201334 (2017).","journal-title":"Innov. Clin. Neurosci."},{"key":"e_1_3_3_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sleep.2009.11.015"},{"key":"e_1_3_3_9_1","volume-title":"US Department of Health and Human Services, E11 \u2013 ICH Harmonised Tripartite Guideline","author":"Clinical investigation of medicinal products in the pediatric population","year":"2000","unstructured":"Clinical investigation of medicinal products in the pediatric population . US Department of Health and Human Services, E11 \u2013 ICH Harmonised Tripartite Guideline. US FDA, Rockville, MD, USA (2000)."},{"key":"e_1_3_3_10_1","unstructured":"Guidance for Industry Nonclinical Safety Evaluation of Pediatric Drug Products \u2013 US Department of Health and Human Services US FDA Rockville MD USA (2006)."},{"key":"e_1_3_3_11_1","unstructured":"Guideline on the need for non-clinical testing in juvenile animals on human pharmaceuticals for paediatric indications. EMA London UK (2001)."},{"key":"e_1_3_3_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yrtph.2013.03.001"},{"key":"e_1_3_3_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yrtph.2011.08.001"},{"key":"e_1_3_3_14_1","unstructured":"National Centre for replacement refinement and reduction of animals in research. www.nc3rs.org.uk."},{"key":"e_1_3_3_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchromb.2008.05.025"},{"key":"e_1_3_3_16_1","doi-asserted-by":"publisher","DOI":"10.4155\/bio.12.205"},{"key":"e_1_3_3_17_1","doi-asserted-by":"publisher","DOI":"10.4155\/bio.13.238"},{"key":"e_1_3_3_18_1","doi-asserted-by":"publisher","DOI":"10.4155\/bio.15.204"},{"key":"e_1_3_3_19_1","doi-asserted-by":"publisher","DOI":"10.4155\/bio.12.25"},{"key":"e_1_3_3_20_1","doi-asserted-by":"publisher","DOI":"10.4155\/bio.14.265"},{"key":"e_1_3_3_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpba.2015.01.052"},{"key":"e_1_3_3_22_1","doi-asserted-by":"publisher","DOI":"10.4155\/bio-2016-4992"},{"key":"e_1_3_3_23_1","doi-asserted-by":"publisher","DOI":"10.4155\/bio-2017-4975"},{"key":"e_1_3_3_24_1","doi-asserted-by":"publisher","DOI":"10.4155\/bio.13.156"},{"key":"e_1_3_3_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchromb.2008.06.046"},{"key":"e_1_3_3_26_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2015.00224"},{"key":"e_1_3_3_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchromb.2011.03.049"},{"key":"e_1_3_3_28_1","unstructured":"Guideline on bioanalytical method validation. EMA London UK (2011)."},{"key":"e_1_3_3_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.aca.2011.02.047"},{"key":"e_1_3_3_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.aca.2017.01.060"}],"container-title":["Bioanalysis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.4155\/bio-2018-0236","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,17]],"date-time":"2024-05-17T17:12:12Z","timestamp":1715965932000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.tandfonline.com\/doi\/full\/10.4155\/bio-2018-0236"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,12,10]]},"references-count":29,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019,1]]}},"alternative-id":["10.4155\/bio-2018-0236"],"URL":"https:\/\/doi.org\/10.4155\/bio-2018-0236","relation":{},"ISSN":["1757-6180","1757-6199"],"issn-type":[{"value":"1757-6180","type":"print"},{"value":"1757-6199","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,12,10]]},"assertion":[{"value":"The publishing and review policy for this title is described in its Aims & Scope.","order":1,"name":"peerreview_statement","label":"Peer Review Statement"},{"value":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=ibio20","URL":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=ibio20","order":2,"name":"aims_and_scope_url","label":"Aim & Scope"},{"value":"2018-09-04","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-10-30","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-12-10","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}