{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T02:58:53Z","timestamp":1776826733438,"version":"3.51.2"},"reference-count":43,"publisher":"Informa UK Limited","issue":"13","content-domain":{"domain":["www.tandfonline.com"],"crossmark-restriction":true},"short-container-title":["Bioanalysis"],"published-print":{"date-parts":[[2023,7]]},"DOI":"10.4155\/bio-2023-0074","type":"journal-article","created":{"date-parts":[[2023,6,24]],"date-time":"2023-06-24T13:03:25Z","timestamp":1687611805000},"page":"711-725","update-policy":"https:\/\/doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":8,"title":["Preclinical Pharmacokinetics of 4-Hydroxy Isoleucine Using Lc\u2013Ms\/Ms: A Potential Polycystic Ovary Syndrome Phytopharmaceutical Therapeutics"],"prefix":"10.1080","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-4656-131X","authenticated-orcid":false,"given":"Sristi","family":"Agrawal","sequence":"first","affiliation":[{"name":"Pharmaceutics & Pharmacokinetics Division, CSIR \u2013 Central Drug Research Institute, Lucknow, 226031, India"},{"name":"Academy of Scientific & Innovative Research, Ghaziabad, 201002, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sachin Nashik","family":"Sanap","sequence":"additional","affiliation":[{"name":"Pharmaceutics & Pharmacokinetics Division, CSIR \u2013 Central Drug Research Institute, Lucknow, 226031, India"},{"name":"Academy of Scientific & Innovative Research, Ghaziabad, 201002, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4841-0140","authenticated-orcid":false,"given":"Amol Chhatrapati","family":"Bisen","sequence":"additional","affiliation":[{"name":"Pharmaceutics & Pharmacokinetics Division, CSIR \u2013 Central Drug Research Institute, Lucknow, 226031, India"},{"name":"Academy of Scientific & Innovative Research, Ghaziabad, 201002, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arpon","family":"Biswas","sequence":"additional","affiliation":[{"name":"Pharmaceutics & Pharmacokinetics Division, CSIR \u2013 Central Drug Research Institute, Lucknow, 226031, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abhijit Deb","family":"Choudhury","sequence":"additional","affiliation":[{"name":"Pharmaceutics & Pharmacokinetics Division, CSIR \u2013 Central Drug Research Institute, Lucknow, 226031, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarvesh Kumar","family":"Verma","sequence":"additional","affiliation":[{"name":"Pharmaceutics & Pharmacokinetics Division, CSIR \u2013 Central Drug Research Institute, Lucknow, 226031, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shubham","family":"Jaiswal","sequence":"additional","affiliation":[{"name":"Academy of Scientific & Innovative Research, Ghaziabad, 201002, India"},{"name":"Division of Medicinal & Process Chemistry, CSIR \u2013 Central Drug Research Institute, Lucknow, 226031, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tadigoppula","family":"Narender","sequence":"additional","affiliation":[{"name":"Academy of Scientific & Innovative Research, Ghaziabad, 201002, India"},{"name":"Division of Medicinal & Process Chemistry, CSIR \u2013 Central Drug Research Institute, Lucknow, 226031, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4844-2388","authenticated-orcid":false,"given":"Rabi Sankar","family":"Bhatta","sequence":"additional","affiliation":[{"name":"Pharmaceutics & Pharmacokinetics Division, CSIR \u2013 Central Drug Research Institute, Lucknow, 226031, India"},{"name":"Academy of Scientific & Innovative Research, Ghaziabad, 201002, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"301","published-online":{"date-parts":[[2023,6,24]]},"reference":[{"key":"e_1_3_6_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-018-0035-5"},{"key":"e_1_3_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpba.2023.115484"},{"key":"e_1_3_6_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/1477-7827-9-39"},{"key":"e_1_3_6_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/bmc.5600"},{"issue":"4","key":"e_1_3_6_7_1","first-page":"353","article-title":"4-Hydroxyisoleucine: a plant-derived treatment for metabolic syndrome.","volume":"10","author":"Jett\u00e9 L Harvey L, Eugeni K, Levens N.","year":"2009","unstructured":"Jett\u00e9 L, Harvey L, Eugeni K, Levens N. 4-Hydroxyisoleucine: a plant-derived treatment for metabolic syndrome. Curr. Opin. Investig. Drugs. 10(4) 353\u2013358 (2009).","journal-title":"Curr. Opin. Investig. Drugs."},{"key":"e_1_3_6_8_1","first-page":"1","volume-title":"Comparative Insilico Analysis of Fenugreek and Flaxseed for Drug Development in Polycystic Ovary Syndrome.","author":"Tariq L","year":"2022","unstructured":"Tariq L . Comparative Insilico Analysis of Fenugreek and Flaxseed for Drug Development in Polycystic Ovary Syndrome.Capital University of Science & Technology, Islamabad, Pakistan, 1\u2013121 (2022). https:\/\/thesis.cust.edu.pk\/UploadedFiles\/LaraibTariq-MBS203029.pdf"},{"key":"e_1_3_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rbmo.2014.03.011"},{"issue":"2","key":"e_1_3_6_10_1","first-page":"90","article-title":"Long term health consequences of polycystic ovarian syndrome: a review analysis","volume":"13","author":"Daniilidis A","year":"2009","unstructured":"Daniilidis A , DinasK. Long term health consequences of polycystic ovarian syndrome: a review analysis. Hippokratia.13(2), 90\u201392 (2009).","journal-title":"Hippokratia."},{"issue":"1","key":"e_1_3_6_11_1","first-page":"41","article-title":"Effects of fenugreek seed on the severity and systemic symptoms of dysmenorrhea","volume":"15","author":"Younesy S","year":"2014","unstructured":"Younesy S , AmiraliakbariS, EsmaeiliSet al. Effects of fenugreek seed on the severity and systemic symptoms of dysmenorrhea. J. Reprod. Infertil.15(1), 41\u201348 (2014).","journal-title":"J. Reprod. Infertil."},{"key":"e_1_3_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.aca.2006.06.034"},{"key":"e_1_3_6_13_1","doi-asserted-by":"publisher","DOI":"10.1080\/10286020.2020.1769609"},{"issue":"4","key":"e_1_3_6_14_1","first-page":"169","article-title":"Fenugreek (Trigonella foenum-graecum L.): an overview","volume":"2","author":"Snehlata HS","year":"2011","unstructured":"Snehlata HS , PayalDR. Fenugreek (Trigonella foenum-graecum L.): an overview. Int. J. Curr. Pharm. Rev. Res.2(4), 169\u2013187 (2011).","journal-title":"Int. J. Curr. Pharm. Rev. Res."},{"key":"e_1_3_6_15_1","doi-asserted-by":"publisher","DOI":"10.1271\/bbb.80805"},{"key":"e_1_3_6_16_1","doi-asserted-by":"publisher","DOI":"10.4161\/cbt.8.3.7443"},{"key":"e_1_3_6_17_1","doi-asserted-by":"publisher","DOI":"10.3181\/00379727-182-42322"},{"key":"e_1_3_6_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jssas.2016.01.007"},{"key":"e_1_3_6_19_1","doi-asserted-by":"publisher","DOI":"10.7150\/ijms.13024"},{"key":"e_1_3_6_20_1","doi-asserted-by":"publisher","DOI":"10.2174\/092986712801323171"},{"key":"e_1_3_6_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0271-5317(05)80822-X"},{"key":"e_1_3_6_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/bmc.5275"},{"key":"e_1_3_6_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2005.10.003"},{"key":"e_1_3_6_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2008.06.081"},{"key":"e_1_3_6_25_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.1999.277.4.E617"},{"key":"e_1_3_6_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phyplu.2021.100141"},{"key":"e_1_3_6_27_1","doi-asserted-by":"publisher","DOI":"10.2337\/diab.47.2.206"},{"key":"e_1_3_6_28_1","doi-asserted-by":"publisher","DOI":"10.1039\/C9RA08121F"},{"key":"e_1_3_6_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/jssc.202100894"},{"issue":"1","key":"e_1_3_6_30_1","first-page":"13","article-title":"Bioanalytical method validation","volume":"10","author":"Imre S","year":"2008","unstructured":"Imre S , VlaseL, MunteanDL. Bioanalytical method validation. Rev. Rom. Med. Lab.10(1), 13\u201321 (2008).","journal-title":"Rev. Rom. Med. Lab."},{"key":"e_1_3_6_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/bmc.5681"},{"key":"e_1_3_6_32_1","doi-asserted-by":"publisher","DOI":"10.4155\/bio.12.107"},{"key":"e_1_3_6_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpba.2021.114463"},{"key":"e_1_3_6_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/sscp.202200098"},{"key":"e_1_3_6_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cjac.2022.100197"},{"key":"e_1_3_6_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpba.2016.02.047"},{"key":"e_1_3_6_37_1","doi-asserted-by":"publisher","DOI":"10.1021\/ac020361s"},{"key":"e_1_3_6_38_1","doi-asserted-by":"publisher","DOI":"10.1039\/D3AY00317E"},{"key":"e_1_3_6_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpba.2016.03.002"},{"key":"e_1_3_6_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fitote.2014.05.004"},{"key":"e_1_3_6_41_1","doi-asserted-by":"publisher","DOI":"10.1124\/dmd.107.019240"},{"key":"e_1_3_6_42_1","doi-asserted-by":"publisher","DOI":"10.1177\/074823379701300401"},{"key":"e_1_3_6_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchromb.2016.07.030"},{"key":"e_1_3_6_44_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00210-018-1518-0"},{"key":"e_1_3_6_45_1","doi-asserted-by":"publisher","DOI":"10.1080\/00498254.2022.2101033"}],"container-title":["Bioanalysis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.4155\/bio-2023-0074","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,17]],"date-time":"2024-05-17T15:59:08Z","timestamp":1715961548000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.tandfonline.com\/doi\/full\/10.4155\/bio-2023-0074"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6,24]]},"references-count":43,"journal-issue":{"issue":"13","published-print":{"date-parts":[[2023,7]]}},"alternative-id":["10.4155\/bio-2023-0074"],"URL":"https:\/\/doi.org\/10.4155\/bio-2023-0074","relation":{},"ISSN":["1757-6180","1757-6199"],"issn-type":[{"value":"1757-6180","type":"print"},{"value":"1757-6199","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,6,24]]},"assertion":[{"value":"The publishing and review policy for this title is described in its Aims & Scope.","order":1,"name":"peerreview_statement","label":"Peer Review Statement"},{"value":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=ibio20","URL":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=ibio20","order":2,"name":"aims_and_scope_url","label":"Aim & Scope"},{"value":"2023-04-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-05-24","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-06-24","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}