{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T16:56:47Z","timestamp":1790009807682,"version":"4.0.1"},"reference-count":114,"publisher":"Informa UK Limited","issue":"12","funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81573283, 21502224"],"award-info":[{"award-number":["81573283, 21502224"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["www.tandfonline.com"],"crossmark-restriction":true},"short-container-title":["Future Med. Chem."],"published-print":{"date-parts":[[2016,8]]},"DOI":"10.4155\/fmc-2016-0020","type":"journal-article","created":{"date-parts":[[2016,7,27]],"date-time":"2016-07-27T17:37:18Z","timestamp":1469641038000},"page":"1435-1454","update-policy":"https:\/\/doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":35,"title":["Strategies in the Discovery of Novel Antifungal Scaffolds"],"prefix":"10.1080","volume":"8","author":[{"given":"Na","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Medicinal Chemistry, School of Pharmacy, Second Military Medical University, 325 Guohe Road, Shanghai200433, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Wang","sequence":"additional","affiliation":[{"name":"Changhai Hospital of Traditional Chinese Medicine, Second Military Medical University, 800 Xiangyin Road, Shanghai200433, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hua","family":"Su","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutics, Jinling Hospital, Nanjing University School of Medicine, Nanjing210002, Nanjing, 210002, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wannian","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Medicinal Chemistry, School of Pharmacy, Second Military Medical University, 325 Guohe Road, Shanghai200433, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunquan","family":"Sheng","sequence":"additional","affiliation":[{"name":"Department of Medicinal Chemistry, School of Pharmacy, Second Military Medical University, 325 Guohe Road, Shanghai200433, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2016,7,27]]},"reference":[{"key":"e_1_3_2_3_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1222236"},{"key":"e_1_3_2_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkn304"},{"key":"e_1_3_2_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10156-007-0595-7"},{"key":"e_1_3_2_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0b013e328322ffac"},{"key":"e_1_3_2_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1130-1406(05)70048-6"},{"key":"e_1_3_2_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0966-842X(03)00117-3"},{"key":"e_1_3_2_9_1","doi-asserted-by":"publisher","DOI":"10.1039\/b820743g"},{"key":"e_1_3_2_10_1","doi-asserted-by":"publisher","DOI":"10.1086\/376634"},{"key":"e_1_3_2_11_1","doi-asserted-by":"publisher","DOI":"10.1179\/joc.2000.12.6.463"},{"key":"e_1_3_2_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/nchembio.1821"},{"key":"e_1_3_2_13_1","doi-asserted-by":"publisher","DOI":"10.2165\/11596540-000000000-00000"},{"key":"e_1_3_2_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2011.11.001"},{"key":"e_1_3_2_15_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.43.12.5848-5859.2005"},{"key":"e_1_3_2_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(02)00181-0"},{"key":"e_1_3_2_17_1","doi-asserted-by":"publisher","DOI":"10.1177\/1060028015581679"},{"key":"e_1_3_2_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkf045"},{"key":"e_1_3_2_19_1","doi-asserted-by":"publisher","DOI":"10.1039\/C3NP70070D"},{"key":"e_1_3_2_20_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00432-11"},{"key":"e_1_3_2_21_1","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a019703"},{"key":"e_1_3_2_22_1","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a019752"},{"key":"e_1_3_2_23_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.47.6.1948-1951.2003"},{"key":"e_1_3_2_24_1","doi-asserted-by":"publisher","DOI":"10.2174\/092986711794480113"},{"key":"e_1_3_2_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/457153a"},{"key":"e_1_3_2_26_1","doi-asserted-by":"publisher","DOI":"10.1039\/c2cs35023h"},{"key":"e_1_3_2_27_1","doi-asserted-by":"publisher","DOI":"10.1021\/co400022r"},{"key":"e_1_3_2_28_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.02445-09"},{"key":"e_1_3_2_29_1","doi-asserted-by":"publisher","DOI":"10.1586\/eri.10.2"},{"key":"e_1_3_2_30_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00477-12"},{"key":"e_1_3_2_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2011.08.029"},{"key":"e_1_3_2_32_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm501814x"},{"key":"e_1_3_2_33_1","doi-asserted-by":"publisher","DOI":"10.1021\/ml400492t"},{"key":"e_1_3_2_34_1","doi-asserted-by":"publisher","DOI":"10.2217\/fmb.14.32"},{"key":"e_1_3_2_35_1","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2010.47"},{"key":"e_1_3_2_36_1","doi-asserted-by":"publisher","DOI":"10.1177\/1087057113496847"},{"key":"e_1_3_2_37_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0033705"},{"key":"e_1_3_2_38_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.00131-07"},{"key":"e_1_3_2_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tim.2011.07.004"},{"key":"e_1_3_2_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mib.2013.03.007"},{"key":"e_1_3_2_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coph.2013.08.008"},{"key":"e_1_3_2_42_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkq530"},{"key":"e_1_3_2_43_1","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2008.141"},{"key":"e_1_3_2_44_1","doi-asserted-by":"publisher","DOI":"10.1038\/npjbiofilms.2015.12"},{"key":"e_1_3_2_45_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1305982110"},{"key":"e_1_3_2_46_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0085836"},{"key":"e_1_3_2_47_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.0030018"},{"key":"e_1_3_2_48_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0007025"},{"key":"e_1_3_2_49_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd3776"},{"key":"e_1_3_2_50_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1002870"},{"key":"e_1_3_2_51_1","first-page":"192","article-title":"Teaching old drugs new tricks: reincarnating immunosuppressants as antifungal drugs","volume":"4","author":"Blankenship JR","year":"2003","unstructured":"Blankenship JR , SteinbachWJ, PerfectJR, HeitmanJ. Teaching old drugs new tricks: reincarnating immunosuppressants as antifungal drugs. Curr. Opin. Investig. Drugs4, 192\u2013199 (2003).","journal-title":"Curr. Opin. Investig. Drugs"},{"key":"e_1_3_2_52_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00212-12"},{"key":"e_1_3_2_53_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01564-08"},{"key":"e_1_3_2_54_1","doi-asserted-by":"publisher","DOI":"10.1128\/EC.00314-12"},{"key":"e_1_3_2_55_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00680-13"},{"key":"e_1_3_2_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2015.01.026"},{"key":"e_1_3_2_57_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01087-13"},{"key":"e_1_3_2_58_1","doi-asserted-by":"publisher","DOI":"10.1039\/b914961a"},{"key":"e_1_3_2_59_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules19032925"},{"key":"e_1_3_2_60_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd4510"},{"key":"e_1_3_2_61_1","doi-asserted-by":"publisher","DOI":"10.1021\/np200906s"},{"key":"e_1_3_2_62_1","doi-asserted-by":"publisher","DOI":"10.1021\/np500032u"},{"key":"e_1_3_2_63_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jnatprod.5b00008"},{"key":"e_1_3_2_64_1","doi-asserted-by":"publisher","DOI":"10.1002\/ejoc.201000916"},{"key":"e_1_3_2_65_1","doi-asserted-by":"publisher","DOI":"10.1002\/1522-2675(20011219)84:12<3766::AID-HLCA3766>3.0.CO;2-Z"},{"key":"e_1_3_2_66_1","first-page":"1099","article-title":"Biologically active metabolites from fungi, 5. palmarumycins C1\u2013C16 from Coniothyrium sp.: isolation, structure elucidation, and biological activity","author":"Krohn K","year":"1994","unstructured":"Krohn K , MichelA, Fl\u00f6rkeU, AustH-J, DraegerS, SchulzB. Biologically active metabolites from fungi, 5. palmarumycins C1\u2013C16 from Coniothyrium sp.: isolation, structure elucidation, and biological activity. Eur. J. Org. Chem.1099\u20131108 (1994).","journal-title":"Eur. J. Org. Chem."},{"key":"e_1_3_2_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fitote.2014.09.015"},{"key":"e_1_3_2_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fitote.2012.05.002"},{"key":"e_1_3_2_69_1","doi-asserted-by":"publisher","DOI":"10.1021\/np070447m"},{"key":"e_1_3_2_70_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jnatprod.5b00470"},{"key":"e_1_3_2_71_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jnatprod.5b00744"},{"key":"e_1_3_2_72_1","doi-asserted-by":"publisher","DOI":"10.1021\/np501052a"},{"key":"e_1_3_2_73_1","doi-asserted-by":"publisher","DOI":"10.1021\/np4001703"},{"key":"e_1_3_2_74_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fitote.2011.11.009"},{"key":"e_1_3_2_75_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fitote.2013.04.011"},{"key":"e_1_3_2_76_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fitote.2011.11.003"},{"key":"e_1_3_2_77_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fitote.2011.12.023"},{"key":"e_1_3_2_78_1","doi-asserted-by":"publisher","DOI":"10.1021\/np50044a029"},{"key":"e_1_3_2_79_1","doi-asserted-by":"publisher","DOI":"10.1021\/np000436s"},{"key":"e_1_3_2_80_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm00100a012"},{"key":"e_1_3_2_81_1","doi-asserted-by":"publisher","DOI":"10.1002\/ardp.200700064"},{"key":"e_1_3_2_82_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2014.07.064"},{"key":"e_1_3_2_83_1","doi-asserted-by":"publisher","DOI":"10.1039\/C5CC05699C"},{"key":"e_1_3_2_84_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1324245111"},{"key":"e_1_3_2_85_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm020362c"},{"key":"e_1_3_2_86_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm051211n"},{"key":"e_1_3_2_87_1","doi-asserted-by":"publisher","DOI":"10.2174\/138945011501140115112242"},{"key":"e_1_3_2_88_1","doi-asserted-by":"publisher","DOI":"10.2174\/187152608784139613"},{"key":"e_1_3_2_89_1","first-page":"222","article-title":"Chitin synthase inhibitors as antifungal agents","volume":"13","author":"Chaudhary PM","year":"2013","unstructured":"Chaudhary PM , TupeSG, DeshpandeMV. Chitin synthase inhibitors as antifungal agents. Mini. Rev. Med. Chem.13, 222\u2013236 (2013).","journal-title":"Mini. Rev. Med. Chem."},{"key":"e_1_3_2_90_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00726-014-1873-1"},{"key":"e_1_3_2_91_1","doi-asserted-by":"publisher","DOI":"10.1002\/cmdc.201402174"},{"key":"e_1_3_2_92_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbpa.2013.09.016"},{"key":"e_1_3_2_93_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2958.2003.03481.x"},{"key":"e_1_3_2_94_1","doi-asserted-by":"publisher","DOI":"10.1021\/cb300235m"},{"key":"e_1_3_2_95_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2010.06.005"},{"key":"e_1_3_2_96_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkr342"},{"key":"e_1_3_2_97_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.05414-11"},{"key":"e_1_3_2_98_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00570-11"},{"key":"e_1_3_2_99_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00291-11"},{"key":"e_1_3_2_100_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00366-11"},{"key":"e_1_3_2_101_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.03944-14"},{"key":"e_1_3_2_102_1","doi-asserted-by":"publisher","DOI":"10.2174\/13816128113199990009"},{"key":"e_1_3_2_103_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm301501k"},{"key":"e_1_3_2_104_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01809-12"},{"key":"e_1_3_2_105_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm030931w"},{"key":"e_1_3_2_106_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chembiol.2008.07.013"},{"key":"e_1_3_2_107_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1747-0285.2008.00745.x"},{"key":"e_1_3_2_108_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2013.01.008"},{"key":"e_1_3_2_109_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm401916j"},{"key":"e_1_3_2_110_1","doi-asserted-by":"publisher","DOI":"10.1517\/17460441.2010.498472"},{"key":"e_1_3_2_111_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00844-08"},{"key":"e_1_3_2_112_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2010.05.024"},{"key":"e_1_3_2_113_1","doi-asserted-by":"publisher","DOI":"10.1248\/bpb.33.192"},{"key":"e_1_3_2_114_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00435-09"},{"key":"e_1_3_2_115_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2010.06.096"},{"key":"e_1_3_2_116_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms7741"}],"container-title":["Future Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.4155\/fmc-2016-0020","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,23]],"date-time":"2024-05-23T19:51:50Z","timestamp":1716493910000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.tandfonline.com\/doi\/full\/10.4155\/fmc-2016-0020"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,7,27]]},"references-count":114,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2016,8]]}},"alternative-id":["10.4155\/fmc-2016-0020"],"URL":"https:\/\/doi.org\/10.4155\/fmc-2016-0020","relation":{},"ISSN":["1756-8919","1756-8927"],"issn-type":[{"value":"1756-8919","type":"print"},{"value":"1756-8927","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,7,27]]},"assertion":[{"value":"The publishing and review policy for this title is described in its Aims & Scope.","order":1,"name":"peerreview_statement","label":"Peer Review Statement"},{"value":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=ifmc20","URL":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=ifmc20","order":2,"name":"aims_and_scope_url","label":"Aim & Scope"},{"value":"2016-01-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-05-13","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-07-27","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}