{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T21:05:55Z","timestamp":1791925555043,"version":"4.3.4"},"reference-count":132,"publisher":"Informa UK Limited","issue":"7","funder":[{"name":"Major Project of Science and Technology of Shandong Province","award":["2015ZDJS04001"],"award-info":[{"award-number":["2015ZDJS04001"]}]}],"content-domain":{"domain":["www.tandfonline.com"],"crossmark-restriction":true},"short-container-title":["Future Med. Chem."],"published-print":{"date-parts":[[2016,5]]},"DOI":"10.4155\/fmc-2016-0024","type":"journal-article","created":{"date-parts":[[2016,5,5]],"date-time":"2016-05-05T12:02:29Z","timestamp":1462449749000},"page":"817-832","update-policy":"https:\/\/doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":96,"title":["Store-Operated Crac Channel Inhibitors: Opportunities and Challenges"],"prefix":"10.1080","volume":"8","author":[{"given":"Chengsen","family":"Tian","sequence":"first","affiliation":[{"name":"Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (MOE), School of Pharmacy, Shandong University, Jinan, Shandong250012, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lupei","family":"Du","sequence":"additional","affiliation":[{"name":"Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (MOE), School of Pharmacy, Shandong University, Jinan, Shandong250012, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yubin","family":"Zhou","sequence":"additional","affiliation":[{"name":"Center for Translational Cancer Research, Institute of Biosciences & Technology, Texas A&M University Health Science Center, Houston, TX77030, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minyong","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (MOE), School of Pharmacy, Shandong University, Jinan, Shandong250012, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2016,5,5]]},"reference":[{"key":"e_1_3_2_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2007.11.028"},{"key":"e_1_3_2_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrm1155"},{"key":"e_1_3_2_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0143-4160(86)90026-6"},{"key":"e_1_3_2_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-065X.2009.00810.x"},{"key":"e_1_3_2_7_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00020.2014"},{"key":"e_1_3_2_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-065X.2009.00816.x"},{"key":"e_1_3_2_9_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.021908.132550"},{"key":"e_1_3_2_10_1","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a003970"},{"key":"e_1_3_2_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd3136"},{"key":"e_1_3_2_12_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2012.233221"},{"key":"e_1_3_2_13_1","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.0312169"},{"key":"e_1_3_2_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni1550"},{"key":"e_1_3_2_15_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.109.196105"},{"key":"e_1_3_2_16_1","doi-asserted-by":"publisher","DOI":"10.1080\/09537100801935710"},{"issue":"2","key":"e_1_3_2_17_1","first-page":"887","article-title":"Blockade of NOX2 and STIM1 signaling limits lipopolysaccharide-induced vascular inflammation","volume":"123","author":"Gandhirajan RK","year":"2013","unstructured":"Gandhirajan RK , MengS, ChandramoorthyHCet al. Blockade of NOX2 and STIM1 signaling limits lipopolysaccharide-induced vascular inflammation. J. Clin. Invest.123 (2), 887\u2013902 (2013).","journal-title":"J. Clin. Invest."},{"key":"e_1_3_2_18_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2008.160481"},{"key":"e_1_3_2_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncb0609-669"},{"key":"e_1_3_2_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature04702"},{"key":"e_1_3_2_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2006.02498.x"},{"key":"e_1_3_2_22_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-07-171611"},{"key":"e_1_3_2_23_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1300910110"},{"key":"e_1_3_2_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri2152"},{"key":"e_1_3_2_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2008.12.019"},{"key":"e_1_3_2_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)81683-9"},{"key":"e_1_3_2_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.29840"},{"key":"e_1_3_2_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2005.05.055"},{"key":"e_1_3_2_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature04147"},{"key":"e_1_3_2_30_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1127883"},{"key":"e_1_3_2_31_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0603161103"},{"key":"e_1_3_2_32_1","doi-asserted-by":"publisher","DOI":"10.1159\/000015341"},{"key":"e_1_3_2_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature05637"},{"key":"e_1_3_2_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2008.08.006"},{"key":"e_1_3_2_35_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0608358103"},{"key":"e_1_3_2_36_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncb1842"},{"key":"e_1_3_2_37_1","doi-asserted-by":"publisher","DOI":"10.1038\/nsmb.2625"},{"key":"e_1_3_2_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2007.11.039"},{"key":"e_1_3_2_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-407870-3.00010-X"},{"key":"e_1_3_2_40_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M609630200"},{"key":"e_1_3_2_41_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-065X.2009.00820.x"},{"key":"e_1_3_2_42_1","doi-asserted-by":"publisher","DOI":"10.1038\/361315a0"},{"key":"e_1_3_2_43_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M608247200"},{"key":"e_1_3_2_44_1","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.e10-02-0145"},{"key":"e_1_3_2_45_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrm3414"},{"key":"e_1_3_2_46_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms8826"},{"key":"e_1_3_2_47_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M114.610022"},{"key":"e_1_3_2_48_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature07065"},{"key":"e_1_3_2_49_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0702866104"},{"key":"e_1_3_2_50_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M704339200"},{"key":"e_1_3_2_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-407870-3.00002-0"},{"key":"e_1_3_2_52_1","doi-asserted-by":"publisher","DOI":"10.1038\/nsmb.1724"},{"key":"e_1_3_2_53_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1118947109"},{"key":"e_1_3_2_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2009.05.020"},{"key":"e_1_3_2_55_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.C800229200"},{"key":"e_1_3_2_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2009.02.014"},{"key":"e_1_3_2_57_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni1574"},{"key":"e_1_3_2_58_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.00360-08"},{"key":"e_1_3_2_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(00)80188-0"},{"key":"e_1_3_2_60_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00374562"},{"key":"e_1_3_2_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0143-4160(96)90068-8"},{"issue":"2","key":"e_1_3_2_62_1","first-page":"84","article-title":"Pharmacology of capacitative calcium entry","volume":"1","author":"Putney JW","year":"2001","unstructured":"Putney JW . Pharmacology of capacitative calcium entry. Mol. Interv.1 (2), 84\u201394 (2001).","journal-title":"Mol. Interv."},{"key":"e_1_3_2_63_1","doi-asserted-by":"publisher","DOI":"10.1002\/cmdc.200800452"},{"key":"e_1_3_2_64_1","doi-asserted-by":"publisher","DOI":"10.4155\/ppa.14.7"},{"key":"e_1_3_2_65_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1993.sp019681"},{"key":"e_1_3_2_66_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature05108"},{"key":"e_1_3_2_67_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2012.233098"},{"key":"e_1_3_2_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)99100-3"},{"key":"e_1_3_2_69_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0909574106"},{"key":"e_1_3_2_70_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2006.08.085"},{"key":"e_1_3_2_71_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1228757"},{"key":"e_1_3_2_72_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1991.sp018746"},{"key":"e_1_3_2_73_1","doi-asserted-by":"publisher","DOI":"10.1038\/35077544"},{"key":"e_1_3_2_74_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1994.tb17072.x"},{"key":"e_1_3_2_75_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.2010.00786.x"},{"key":"e_1_3_2_76_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.287.5458.1647"},{"key":"e_1_3_2_77_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7793.2001.t01-1-00003.x"},{"key":"e_1_3_2_78_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M107755200"},{"key":"e_1_3_2_79_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ceca.2009.10.004"},{"key":"e_1_3_2_80_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.jbchem.a021780"},{"key":"e_1_3_2_81_1","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/16.11.3078"},{"key":"e_1_3_2_82_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M003147200"},{"key":"e_1_3_2_83_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.02-0037rev"},{"key":"e_1_3_2_84_1","doi-asserted-by":"publisher","DOI":"10.1042\/bj3540285"},{"issue":"6","key":"e_1_3_2_85_1","first-page":"429","article-title":"2-aminoethoxydiphenyl borate (2-APB) inhibits capacitative calcium entry independently of the function of inositol 1,4,5-trisphosphate receptors","volume":"7","author":"Iwasaki H","year":"2001","unstructured":"Iwasaki H , MoriY, HaraY, UchidaK, ZhouH, MikoshibaK. 2-aminoethoxydiphenyl borate (2-APB) inhibits capacitative calcium entry independently of the function of inositol 1,4,5-trisphosphate receptors. Receptors Channels7 (6), 429\u2013439 (2001).","journal-title":"Receptors Channels"},{"key":"e_1_3_2_86_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2008.151365"},{"key":"e_1_3_2_87_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M801535200"},{"key":"e_1_3_2_88_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2008.162503"},{"key":"e_1_3_2_89_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2007.03.065"},{"key":"e_1_3_2_90_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M801536200"},{"key":"e_1_3_2_91_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M803101200"},{"key":"e_1_3_2_92_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0143416002001562"},{"key":"e_1_3_2_93_1","doi-asserted-by":"publisher","DOI":"10.1054\/ceca.2000.0163"},{"key":"e_1_3_2_94_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M404164200"},{"key":"e_1_3_2_95_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ceca.2014.10.005"},{"key":"e_1_3_2_96_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms4183"},{"key":"e_1_3_2_97_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00232-011-9363-9"},{"key":"e_1_3_2_98_1","doi-asserted-by":"publisher","DOI":"10.4161\/chan.21628"},{"key":"e_1_3_2_99_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ceca.2012.08.005"},{"key":"e_1_3_2_100_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm990615a"},{"key":"e_1_3_2_101_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M107919200"},{"key":"e_1_3_2_102_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0008-8749(03)00005-4"},{"key":"e_1_3_2_103_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.170.9.4441"},{"key":"e_1_3_2_104_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M309297200"},{"key":"e_1_3_2_105_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocel.2009.11.019"},{"key":"e_1_3_2_106_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.272.42.26555"},{"key":"e_1_3_2_107_1","doi-asserted-by":"publisher","DOI":"10.1124\/mol.105.021154"},{"key":"e_1_3_2_108_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M411797200"},{"key":"e_1_3_2_109_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.2012.02126.x"},{"key":"e_1_3_2_110_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocel.2011.04.016"},{"issue":"6","key":"e_1_3_2_111_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.jaci.2012.01.070","article-title":"CRACM\/Orai ion channel expression and function in human lung mast cells","volume":"129","author":"Ashmole I","year":"2012","unstructured":"Ashmole I , DuffySM, LeylandML, MorrisonVS, BeggM, BraddingP. CRACM\/Orai ion channel expression and function in human lung mast cells. J. Allergy Clin. Immunol.129 (6\u20133), 1628\u20131635.e1622 (2012).","journal-title":"J. Allergy Clin. Immunol."},{"key":"e_1_3_2_112_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2013.02.022"},{"key":"e_1_3_2_113_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ceca.2012.11.005"},{"key":"e_1_3_2_114_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2007.01.055"},{"key":"e_1_3_2_115_1","first-page":"61","article-title":"Structure\u2013function relationship of the TRP channel superfamily","volume":"156","author":"Owsianik G","year":"2006","unstructured":"Owsianik G , D'hoedtD, VoetsT, NiliusB. Structure\u2013function relationship of the TRP channel superfamily. Rev. Physiol. Biochem. Pharmacol.156, 61\u201390 (2006).","journal-title":"Rev. Physiol. Biochem. Pharmacol."},{"key":"e_1_3_2_116_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M804942200"},{"key":"e_1_3_2_117_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0802887"},{"key":"e_1_3_2_118_1","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1996.1250"},{"key":"e_1_3_2_119_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.023903"},{"issue":"3","key":"e_1_3_2_120_1","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1016\/S0026-895X(24)05654-2","article-title":"Diethylstilbestrol is a potent inhibitor of store-operated channels and capacitative Ca2+ influx","volume":"66","author":"Zakharov SI","year":"2004","unstructured":"Zakharov SI , SmaniT, DobrydnevaYet al. Diethylstilbestrol is a potent inhibitor of store-operated channels and capacitative Ca2+ influx. Mol. Pharmacol.66 (3), 702\u2013707 (2004).","journal-title":"Mol. Pharmacol."},{"key":"e_1_3_2_121_1","doi-asserted-by":"publisher","DOI":"10.4161\/chan.3.2.8609"},{"issue":"6","key":"e_1_3_2_122_1","first-page":"1600","article-title":"A phase I trial of carboxyamido-triazole and paclitaxel for relapsed solid tumors: potential efficacy of the combination and demonstration of pharmacokinetic interaction","volume":"7","author":"Kohn EC","year":"2001","unstructured":"Kohn EC , ReedE, SarosyGAet al. A phase I trial of carboxyamido-triazole and paclitaxel for relapsed solid tumors: potential efficacy of the combination and demonstration of pharmacokinetic interaction. Clin. Cancer Res.7 (6), 1600\u20131609 (2001).","journal-title":"Clin. Cancer Res."},{"key":"e_1_3_2_123_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2003.04.136"},{"key":"e_1_3_2_124_1","doi-asserted-by":"publisher","DOI":"10.1210\/mend.11.3.9894"},{"key":"e_1_3_2_125_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.180143997"},{"key":"e_1_3_2_126_1","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/cdf675"},{"key":"e_1_3_2_127_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.02663"},{"key":"e_1_3_2_128_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molimm.2012.12.011"},{"key":"e_1_3_2_129_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbalip.2014.04.006"},{"key":"e_1_3_2_130_1","doi-asserted-by":"publisher","DOI":"10.1038\/aps.2015.52"},{"key":"e_1_3_2_131_1","doi-asserted-by":"publisher","DOI":"10.4161\/chan.25292"},{"key":"e_1_3_2_132_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.10024"},{"key":"e_1_3_2_133_1","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.3350"},{"key":"e_1_3_2_134_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms9021"}],"container-title":["Future Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.4155\/fmc-2016-0024","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,2]],"date-time":"2025-06-02T20:54:23Z","timestamp":1748897663000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.tandfonline.com\/doi\/full\/10.4155\/fmc-2016-0024"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,5]]},"references-count":132,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2016,5]]}},"alternative-id":["10.4155\/fmc-2016-0024"],"URL":"https:\/\/doi.org\/10.4155\/fmc-2016-0024","relation":{},"ISSN":["1756-8919","1756-8927"],"issn-type":[{"value":"1756-8919","type":"print"},{"value":"1756-8927","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,5]]},"assertion":[{"value":"The publishing and review policy for this title is described in its Aims & Scope.","order":1,"name":"peerreview_statement","label":"Peer Review Statement"},{"value":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=ifmc20","URL":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=ifmc20","order":2,"name":"aims_and_scope_url","label":"Aim & Scope"},{"value":"2016-01-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-03-04","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-05-05","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}