{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T09:42:29Z","timestamp":1780047749629,"version":"3.53.1"},"reference-count":107,"publisher":"Informa UK Limited","issue":"10","funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["R01GM054226, R01AI069313"],"award-info":[{"award-number":["R01GM054226, R01AI069313"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["www.tandfonline.com"],"crossmark-restriction":true},"short-container-title":["Future Med. Chem."],"published-print":{"date-parts":[[2016,6]]},"DOI":"10.4155\/fmc-2016-0042","type":"journal-article","created":{"date-parts":[[2016,6,10]],"date-time":"2016-06-10T16:11:33Z","timestamp":1465575093000},"page":"1085-1100","update-policy":"https:\/\/doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":38,"title":["Targeting Bacterial Topoisomerases: How to Counter Mechanisms of Resistance"],"prefix":"10.1080","volume":"8","author":[{"given":"Yuk-Ching","family":"Tse-Dinh","sequence":"first","affiliation":[{"name":"Department of Chemistry & Biochemistry, Florida International University, 11200 SW 8 Street, Miami, FL33199, USA"},{"name":"Biomolecular Sciences Institute, Florida International University, 11200 SW 8 Street, Miami, FL33199, USA Tel.:  Fax:"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2016,6,10]]},"reference":[{"key":"e_1_3_3_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrm831"},{"key":"e_1_3_3_4_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-biochem-061809-100002"},{"key":"e_1_3_3_5_1","doi-asserted-by":"publisher","DOI":"10.1017\/S003358350800468X"},{"key":"e_1_3_3_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biochi.2006.12.009"},{"key":"e_1_3_3_7_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi5000564"},{"key":"e_1_3_3_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkg208"},{"key":"e_1_3_3_9_1","doi-asserted-by":"publisher","DOI":"10.1021\/cr030101q"},{"key":"e_1_3_3_10_1","doi-asserted-by":"publisher","DOI":"10.1086\/428051"},{"key":"e_1_3_3_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12879-015-1282-4"},{"key":"e_1_3_3_12_1","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/976273"},{"key":"e_1_3_3_13_1","doi-asserted-by":"publisher","DOI":"10.3109\/23744235.2015.1061205"},{"key":"e_1_3_3_14_1","unstructured":"Stop TB . www.stopTB.org."},{"key":"e_1_3_3_15_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1001300"},{"key":"e_1_3_3_16_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200308-1159OC"},{"key":"e_1_3_3_17_1","doi-asserted-by":"publisher","DOI":"10.2147\/CLEP.S35839"},{"key":"e_1_3_3_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)62002-X"},{"key":"e_1_3_3_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCP.0000000000000045"},{"key":"e_1_3_3_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.13128"},{"key":"e_1_3_3_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2015.439"},{"key":"e_1_3_3_22_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.74.11.4772"},{"key":"e_1_3_3_23_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.74.11.4767"},{"key":"e_1_3_3_24_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.40.10.2321"},{"key":"e_1_3_3_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrm3228"},{"key":"e_1_3_3_26_1","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.53.1.296-298.1985"},{"key":"e_1_3_3_27_1","doi-asserted-by":"publisher","DOI":"10.1128\/jb.140.2.424-435.1979"},{"key":"e_1_3_3_28_1","doi-asserted-by":"publisher","DOI":"10.1021\/cb300648v"},{"key":"e_1_3_3_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2015.09.059"},{"key":"e_1_3_3_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/msb4100135"},{"key":"e_1_3_3_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chembiol.2010.04.012"},{"key":"e_1_3_3_32_1","doi-asserted-by":"publisher","DOI":"10.1006\/jmbi.1996.0274"},{"key":"e_1_3_3_33_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkp486"},{"key":"e_1_3_3_34_1","doi-asserted-by":"publisher","DOI":"10.1021\/cr4003984"},{"key":"e_1_3_3_35_1","doi-asserted-by":"publisher","DOI":"10.2174\/1568026613666131113153251"},{"key":"e_1_3_3_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coph.2014.09.007"},{"key":"e_1_3_3_37_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.02820-15"},{"key":"e_1_3_3_38_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.02778-13"},{"key":"e_1_3_3_39_1","doi-asserted-by":"publisher","DOI":"10.1021\/ml500069w"},{"key":"e_1_3_3_40_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M115.663534"},{"key":"e_1_3_3_41_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.04124-14"},{"key":"e_1_3_3_42_1","doi-asserted-by":"publisher","DOI":"10.1021\/ml500531p"},{"key":"e_1_3_3_43_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkv161"},{"key":"e_1_3_3_44_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0084409"},{"key":"e_1_3_3_45_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.04347-14"},{"key":"e_1_3_3_46_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm500563g"},{"key":"e_1_3_3_47_1","doi-asserted-by":"publisher","DOI":"10.1111\/nyas.12830"},{"key":"e_1_3_3_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tim.2014.04.007"},{"key":"e_1_3_3_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2012.02.007"},{"key":"e_1_3_3_50_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms7947"},{"key":"e_1_3_3_51_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1525055113"},{"key":"e_1_3_3_52_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1525047113"},{"key":"e_1_3_3_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2015.04.033"},{"key":"e_1_3_3_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2015.09.006"},{"key":"e_1_3_3_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2014.05.090"},{"key":"e_1_3_3_56_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0119013"},{"key":"e_1_3_3_57_1","doi-asserted-by":"publisher","DOI":"10.2174\/1389450116666151001103948"},{"key":"e_1_3_3_58_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2015.00421"},{"key":"e_1_3_3_59_1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00016-09"},{"issue":"1","key":"e_1_3_3_60_1","first-page":"81","article-title":"Towards an integrated model of bacterial conjugation","volume":"39","author":"Cabezon E","year":"2015","unstructured":"Cabezon E , Ripoll-RozadaJ, PenaA, de la CruzF, ArechagaI. Towards an integrated model of bacterial conjugation. FEMS Microbiol. Rev.39 (1), 81\u201395 (2015).","journal-title":"FEMS Microbiol. Rev."},{"key":"e_1_3_3_61_1","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.01032-15"},{"key":"e_1_3_3_62_1","doi-asserted-by":"publisher","DOI":"10.1038\/nsmb.1892"},{"key":"e_1_3_3_63_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm501590q"},{"key":"e_1_3_3_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2015.04.063"},{"key":"e_1_3_3_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2015.06.061"},{"key":"e_1_3_3_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2015.06.057"},{"key":"e_1_3_3_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2015.04.002"},{"key":"e_1_3_3_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2015.03.044"},{"key":"e_1_3_3_69_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature09197"},{"key":"e_1_3_3_70_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms10048"},{"key":"e_1_3_3_71_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00247-08"},{"key":"e_1_3_3_72_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm501174m"},{"key":"e_1_3_3_73_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.04456-14"},{"key":"e_1_3_3_74_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep11827"},{"key":"e_1_3_3_75_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2014.02.017"},{"key":"e_1_3_3_76_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2013.08.094"},{"key":"e_1_3_3_77_1","doi-asserted-by":"publisher","DOI":"10.1021\/acschembio.5b00669"},{"key":"e_1_3_3_78_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioorg.2015.07.004"},{"key":"e_1_3_3_79_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2015.08.004"},{"key":"e_1_3_3_80_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2016.01.009"},{"key":"e_1_3_3_81_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsmedchemlett.5b00266"},{"key":"e_1_3_3_82_1","doi-asserted-by":"publisher","DOI":"10.2174\/187152607781001763"},{"key":"e_1_3_3_83_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2014.12.001"},{"key":"e_1_3_3_84_1","doi-asserted-by":"publisher","DOI":"10.1039\/C4OB02049A"},{"key":"e_1_3_3_85_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00304-13"},{"issue":"3","key":"e_1_3_3_86_1","first-page":"455","article-title":"Looking for the new preparations for antibacterial therapy III. New antimicrobial agents from the quinolones group in clinical trials","volume":"67","author":"Karpiuk I","year":"2013","unstructured":"Karpiuk I , TyskiS. Looking for the new preparations for antibacterial therapy III. New antimicrobial agents from the quinolones group in clinical trials. Przegl. Epidemiol.67 (3), 455\u201360, 557\u201361 (2013).","journal-title":"Przegl. Epidemiol."},{"key":"e_1_3_3_87_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2014.04.037"},{"key":"e_1_3_3_88_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2014.05.018"},{"key":"e_1_3_3_89_1","doi-asserted-by":"publisher","DOI":"10.4155\/fmc.14.157"},{"key":"e_1_3_3_90_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2180-12-26"},{"key":"e_1_3_3_91_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-1119(98)00065-1"},{"key":"e_1_3_3_92_1","doi-asserted-by":"publisher","DOI":"10.1111\/1574-6968.12412"},{"key":"e_1_3_3_93_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tube.2015.05.004"},{"key":"e_1_3_3_94_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.1993.tb01127.x"},{"key":"e_1_3_3_95_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.171579898"},{"key":"e_1_3_3_96_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.04516-14"},{"key":"e_1_3_3_97_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2014.03.029"},{"key":"e_1_3_3_98_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejps.2015.02.017"},{"key":"e_1_3_3_99_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0966-842X(97)01080-9"},{"key":"e_1_3_3_100_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1574-6968.1999.tb13770.x"},{"key":"e_1_3_3_101_1","doi-asserted-by":"publisher","DOI":"10.1099\/mic.0.28022-0"},{"key":"e_1_3_3_102_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2958.2000.01805.x"},{"key":"e_1_3_3_103_1","doi-asserted-by":"publisher","DOI":"10.1128\/JB.182.3.829-832.2000"},{"key":"e_1_3_3_104_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00855-15"},{"key":"e_1_3_3_105_1","doi-asserted-by":"publisher","DOI":"10.1111\/1574-6976.12077"},{"key":"e_1_3_3_106_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.biochem.5b00109"},{"key":"e_1_3_3_107_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dku080"},{"key":"e_1_3_3_108_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tube.2015.02.028"},{"key":"e_1_3_3_109_1","doi-asserted-by":"publisher","DOI":"10.1111\/joim.12264"}],"container-title":["Future Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.4155\/fmc-2016-0042","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,23]],"date-time":"2024-05-23T19:53:52Z","timestamp":1716494032000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.tandfonline.com\/doi\/full\/10.4155\/fmc-2016-0042"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,6]]},"references-count":107,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2016,6]]}},"alternative-id":["10.4155\/fmc-2016-0042"],"URL":"https:\/\/doi.org\/10.4155\/fmc-2016-0042","relation":{},"ISSN":["1756-8919","1756-8927"],"issn-type":[{"value":"1756-8919","type":"print"},{"value":"1756-8927","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,6]]},"assertion":[{"value":"The publishing and review policy for this title is described in its Aims & Scope.","order":1,"name":"peerreview_statement","label":"Peer Review Statement"},{"value":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=ifmc20","URL":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=ifmc20","order":2,"name":"aims_and_scope_url","label":"Aim & Scope"},{"value":"2016-02-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-04-26","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-06-10","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}