{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T06:17:55Z","timestamp":1790144275617,"version":"4.0.1"},"reference-count":90,"publisher":"Informa UK Limited","issue":"1","content-domain":{"domain":["www.tandfonline.com"],"crossmark-restriction":true},"short-container-title":["Future Med. Chem."],"published-print":{"date-parts":[[2017,1]]},"DOI":"10.4155\/fmc-2016-0180","type":"journal-article","created":{"date-parts":[[2016,12,13]],"date-time":"2016-12-13T11:52:09Z","timestamp":1481629929000},"page":"61-77","update-policy":"https:\/\/doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":73,"title":["Polyamine-Trypanothione Pathway: An Update"],"prefix":"10.1080","volume":"9","author":[{"given":"Andrea","family":"Ilari","sequence":"first","affiliation":[{"name":"CNR \u2013 National Research Council of Italy, Institute of Molecular Biology &amp; Pathology, c\/o Department of Biochemical Sciences \u201cA. Rossi Fanelli\u201d, University Sapienza, P.le Aldo Moro 5, 00185 \u2013 Rome, Italy"},{"name":"Istituto Pasteur Fondazione Cenci-Bolognetti c\/o Department of Biochemical Sciences \u201cA. Rossi Fanelli\u201d, University Sapienza, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annarita","family":"Fiorillo","sequence":"additional","affiliation":[{"name":"CNR \u2013 National Research Council of Italy, Institute of Molecular Biology &amp; Pathology, c\/o Department of Biochemical Sciences \u201cA. Rossi Fanelli\u201d, University Sapienza, P.le Aldo Moro 5, 00185 \u2013 Rome, Italy"},{"name":"Department of Biochemical Sciences \u201cA. Rossi Fanelli\u201d, University Sapienza, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilaria","family":"Genovese","sequence":"additional","affiliation":[{"name":"Department of Biochemical Sciences \u201cA. Rossi Fanelli\u201d, University Sapienza, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianni","family":"Colotti","sequence":"additional","affiliation":[{"name":"CNR \u2013 National Research Council of Italy, Institute of Molecular Biology &amp; Pathology, c\/o Department of Biochemical Sciences \u201cA. Rossi Fanelli\u201d, University Sapienza, P.le Aldo Moro 5, 00185 \u2013 Rome, Italy"},{"name":"Istituto Pasteur Fondazione Cenci-Bolognetti c\/o Department of Biochemical Sciences \u201cA. Rossi Fanelli\u201d, University Sapienza, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2016,12,13]]},"reference":[{"key":"e_1_3_3_3_1","unstructured":"World Health Organization (2016). Global Health Observatory Data \u2013 Leishmaniasis. www.who.int\/gho\/neglected_diseases\/leishmaniasis\/en\/Global Health Observatory."},{"key":"e_1_3_3_4_1","doi-asserted-by":"publisher","DOI":"10.1086\/314896"},{"key":"e_1_3_3_5_1","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.2001.65.193"},{"key":"e_1_3_3_6_1","doi-asserted-by":"publisher","DOI":"10.26719\/2003.9.4.837"},{"key":"e_1_3_3_7_1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.19.1.111-126.2006"},{"key":"e_1_3_3_8_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.0030162"},{"key":"e_1_3_3_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(91)91708-3"},{"key":"e_1_3_3_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00726-010-0630-3"},{"key":"e_1_3_3_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/9783527670383"},{"key":"e_1_3_3_12_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.021908.132532"},{"key":"e_1_3_3_13_1","doi-asserted-by":"publisher","DOI":"10.4155\/fmc.13.146"},{"key":"e_1_3_3_14_1","first-page":"407","volume-title":"Metal Ions in Biological Systems","author":"Ash DE","year":"1999","unstructured":"Ash DE , CoxJD, ChristiansonDW. Arginase: a binuclear manganese metalloenzyme. Manganese and its role in biological processes. In : Metal Ions in Biological Systems. SigelA, SigelH (Eds). Marcel Dekker, NY, USA, 407\u2013428 (1999)."},{"key":"e_1_3_3_15_1","doi-asserted-by":"publisher","DOI":"10.1021\/ar040183k"},{"key":"e_1_3_3_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1471-4922(02)00010-7"},{"key":"e_1_3_3_17_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1000899"},{"key":"e_1_3_3_18_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M402042200"},{"key":"e_1_3_3_19_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0803979"},{"key":"e_1_3_3_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molbiopara.2009.01.001"},{"key":"e_1_3_3_21_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0034022"},{"key":"e_1_3_3_22_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.193.6.777"},{"key":"e_1_3_3_23_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.73.9.6085-6090.2005"},{"key":"e_1_3_3_24_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.04-3416fje"},{"key":"e_1_3_3_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.abb.2013.03.015"},{"key":"e_1_3_3_26_1","doi-asserted-by":"publisher","DOI":"10.1107\/S2053230X16003630"},{"key":"e_1_3_3_27_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules21050589"},{"key":"e_1_3_3_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fitote.2007.03.013"},{"key":"e_1_3_3_29_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.274.6.3781"},{"key":"e_1_3_3_30_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.01236-08"},{"key":"e_1_3_3_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)45885-1"},{"key":"e_1_3_3_32_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M110118200"},{"key":"e_1_3_3_33_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi9915115"},{"key":"e_1_3_3_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0969-2126(99)80073-2"},{"key":"e_1_3_3_35_1","doi-asserted-by":"publisher","DOI":"10.1006\/jmbi.1999.3331"},{"key":"e_1_3_3_36_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.38.3.563"},{"key":"e_1_3_3_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4894(87)90148-2"},{"key":"e_1_3_3_38_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1550-7408.1986.tb05654.x"},{"key":"e_1_3_3_39_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1020919525067"},{"key":"e_1_3_3_40_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01055-06"},{"key":"e_1_3_3_41_1","doi-asserted-by":"publisher","DOI":"10.1042\/BJ20070188"},{"key":"e_1_3_3_42_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00044-012-0035-9"},{"key":"e_1_3_3_43_1","doi-asserted-by":"publisher","DOI":"10.1080\/07391102.2012.682212"},{"key":"e_1_3_3_44_1","doi-asserted-by":"publisher","DOI":"10.1111\/cbdd.12665"},{"key":"e_1_3_3_45_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.40.6.1448"},{"key":"e_1_3_3_46_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.40.6.1442"},{"key":"e_1_3_3_47_1","doi-asserted-by":"publisher","DOI":"10.1042\/BST0350314"},{"key":"e_1_3_3_48_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00073-11"},{"key":"e_1_3_3_49_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi602498k"},{"key":"e_1_3_3_50_1","doi-asserted-by":"publisher","DOI":"10.1002\/pro.717"},{"key":"e_1_3_3_51_1","doi-asserted-by":"publisher","DOI":"10.1107\/S1399004715013048"},{"key":"e_1_3_3_52_1","doi-asserted-by":"publisher","DOI":"10.1006\/phrs.1996.0011"},{"key":"e_1_3_3_53_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.04169-14"},{"key":"e_1_3_3_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2014.12.008"},{"key":"e_1_3_3_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbagen.2008.03.006"},{"key":"e_1_3_3_56_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M801850200"},{"key":"e_1_3_3_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2014.05.007"},{"key":"e_1_3_3_58_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-4658.2012.08557.x"},{"key":"e_1_3_3_59_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.2009.06907.x"},{"key":"e_1_3_3_60_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M109.045336"},{"key":"e_1_3_3_61_1","doi-asserted-by":"publisher","DOI":"10.1002\/cmdc.201100420"},{"key":"e_1_3_3_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpb.2013.08.014"},{"key":"e_1_3_3_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2016.06.023"},{"key":"e_1_3_3_64_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0004617"},{"key":"e_1_3_3_65_1","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/16.10.2590"},{"key":"e_1_3_3_66_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.9.5311"},{"key":"e_1_3_3_67_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm900185q"},{"key":"e_1_3_3_68_1","doi-asserted-by":"publisher","DOI":"10.2174\/092986609787316306"},{"key":"e_1_3_3_69_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-1033.1995.tb20583.x"},{"key":"e_1_3_3_70_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm981074c"},{"key":"e_1_3_3_71_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm000219o"},{"key":"e_1_3_3_72_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinorgbio.2006.08.015"},{"key":"e_1_3_3_73_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinorgbio.2009.02.011"},{"key":"e_1_3_3_74_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00726-011-0997-9"},{"key":"e_1_3_3_75_1","doi-asserted-by":"publisher","DOI":"10.1002\/cmdc.201300276"},{"key":"e_1_3_3_76_1","doi-asserted-by":"publisher","DOI":"10.1021\/ml1002629"},{"key":"e_1_3_3_77_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0134(199601)24:1<73::AID-PROT5>3.0.CO;2-P"},{"key":"e_1_3_3_78_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm200312v"},{"key":"e_1_3_3_79_1","doi-asserted-by":"publisher","DOI":"10.1002\/cmdc.201300176"},{"key":"e_1_3_3_80_1","doi-asserted-by":"publisher","DOI":"10.1021\/cc990013c"},{"key":"e_1_3_3_81_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-894X(00)00471-6"},{"key":"e_1_3_3_82_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm000156"},{"key":"e_1_3_3_83_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0968-0896(00)00312-6"},{"key":"e_1_3_3_84_1","doi-asserted-by":"publisher","DOI":"10.1002\/cmdc.201402032"},{"key":"e_1_3_3_85_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0003773"},{"key":"e_1_3_3_86_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2958.2000.01721.x"},{"key":"e_1_3_3_87_1","doi-asserted-by":"publisher","DOI":"10.2174\/0929867311320210005"},{"key":"e_1_3_3_88_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0001781"},{"key":"e_1_3_3_89_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep09705"},{"key":"e_1_3_3_90_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M111.338285"},{"key":"e_1_3_3_91_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep08771"},{"key":"e_1_3_3_92_1","doi-asserted-by":"publisher","DOI":"10.1002\/cmdc.201300399"}],"container-title":["Future Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.4155\/fmc-2016-0180","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,23]],"date-time":"2024-05-23T19:50:58Z","timestamp":1716493858000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.tandfonline.com\/doi\/full\/10.4155\/fmc-2016-0180"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,12,13]]},"references-count":90,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2017,1]]}},"alternative-id":["10.4155\/fmc-2016-0180"],"URL":"https:\/\/doi.org\/10.4155\/fmc-2016-0180","relation":{},"ISSN":["1756-8919","1756-8927"],"issn-type":[{"value":"1756-8919","type":"print"},{"value":"1756-8927","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,12,13]]},"assertion":[{"value":"The publishing and review policy for this title is described in its Aims & Scope.","order":1,"name":"peerreview_statement","label":"Peer Review Statement"},{"value":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=ifmc20","URL":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=ifmc20","order":2,"name":"aims_and_scope_url","label":"Aim & Scope"},{"value":"2016-09-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-11-02","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-12-13","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}