{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T22:33:52Z","timestamp":1784932432141,"version":"3.55.0"},"reference-count":67,"publisher":"Informa UK Limited","issue":"3","funder":[{"DOI":"10.13039\/501100000923","name":"Australian Research Council","doi-asserted-by":"crossref","award":["81402780"],"award-info":[{"award-number":["81402780"]}],"id":[{"id":"10.13039\/501100000923","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["www.tandfonline.com"],"crossmark-restriction":true},"short-container-title":["Future Med. Chem."],"published-print":{"date-parts":[[2017,3]]},"DOI":"10.4155\/fmc-2016-0214","type":"journal-article","created":{"date-parts":[[2017,2,8]],"date-time":"2017-02-08T11:51:22Z","timestamp":1486554682000},"page":"303-314","update-policy":"https:\/\/doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":25,"title":["Kinase Targets in Cns Drug Discovery"],"prefix":"10.1080","volume":"9","author":[{"given":"Hendra","family":"Gunosewoyo","sequence":"first","affiliation":[{"name":"School of Pharmacy, Faculty of Health Sciences, Curtin University, Bentley, Perth, WA6102, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lifang","family":"Yu","sequence":"additional","affiliation":[{"name":"Shanghai Engineering Research Center of Molecular Therapeutics &amp; New Drug Development, School of Chemistry &amp; Molecular Engineering, East China Normal University, 3663 North Zhongshan Road, Shanghai200062, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lenka","family":"Munoz","sequence":"additional","affiliation":[{"name":"School of Medical Sciences, University of Sydney, NSW2006, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Kassiou","sequence":"additional","affiliation":[{"name":"School of Chemistry, University of Sydney, NSW2006, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2017,2,8]]},"reference":[{"key":"e_1_3_2_3_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1075762"},{"key":"e_1_3_2_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tips.2014.09.007"},{"key":"e_1_3_2_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drudis.2015.07.008"},{"key":"e_1_3_2_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drudis.2016.06.007"},{"key":"e_1_3_2_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrclinonc.2014.25"},{"key":"e_1_3_2_8_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.6b00618"},{"key":"e_1_3_2_9_1","unstructured":"FDA . Hematology\/Oncology (Cancer) Approvals & Safety Notifications. www.fda.gov\/Drugs\/InformationOnDrugs\/ApprovedDrugs\/ucm279174.htm."},{"key":"e_1_3_2_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd2999"},{"key":"e_1_3_2_11_1","doi-asserted-by":"publisher","DOI":"10.1042\/BST0371133"},{"key":"e_1_3_2_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2015.10.018"},{"key":"e_1_3_2_13_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnmol.2011.00016"},{"key":"e_1_3_2_14_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnmol.2011.00047"},{"key":"e_1_3_2_15_1","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2015.00055"},{"key":"e_1_3_2_16_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-141959"},{"key":"e_1_3_2_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/jnc.12203"},{"key":"e_1_3_2_18_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI64516"},{"key":"e_1_3_2_19_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja068969w"},{"key":"e_1_3_2_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2013.07.010"},{"key":"e_1_3_2_21_1","unstructured":"Actuate Therapeutics I (2016). https:\/\/actuatetherapeutics.com\/timeline\/."},{"key":"e_1_3_2_22_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnmol.2014.00057"},{"key":"e_1_3_2_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2013.04.086"},{"key":"e_1_3_2_24_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.5b00261"},{"key":"e_1_3_2_25_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm401654j"},{"key":"e_1_3_2_26_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm5014055"},{"key":"e_1_3_2_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2013.02.041"},{"key":"e_1_3_2_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2013.05.054"},{"key":"e_1_3_2_29_1","doi-asserted-by":"publisher","DOI":"10.1021\/ml300123a"},{"key":"e_1_3_2_30_1","doi-asserted-by":"publisher","DOI":"10.1021\/cb300610s"},{"key":"e_1_3_2_31_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddr348"},{"key":"e_1_3_2_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri3495"},{"key":"e_1_3_2_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2009.11.010"},{"key":"e_1_3_2_34_1","doi-asserted-by":"publisher","DOI":"10.1186\/1742-2094-4-21"},{"key":"e_1_3_2_35_1","doi-asserted-by":"publisher","DOI":"10.1021\/acschemneuro.5b00002"},{"key":"e_1_3_2_36_1","doi-asserted-by":"publisher","DOI":"10.1021\/ml2001455"},{"key":"e_1_3_2_37_1","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2015.384"},{"key":"e_1_3_2_38_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-4658.2010.07955.x"},{"key":"e_1_3_2_39_1","doi-asserted-by":"publisher","DOI":"10.1042\/bj3550609"},{"key":"e_1_3_2_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2015.03.004"},{"key":"e_1_3_2_41_1","doi-asserted-by":"publisher","DOI":"10.1042\/bj20021535"},{"key":"e_1_3_2_42_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-2011-101629"},{"key":"e_1_3_2_43_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.6b01083"},{"key":"e_1_3_2_44_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.147553"},{"key":"e_1_3_2_45_1","doi-asserted-by":"publisher","DOI":"10.1038\/45159"},{"key":"e_1_3_2_46_1","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.2011.312"},{"key":"e_1_3_2_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chembiol.2005.05.011"},{"key":"e_1_3_2_48_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1432-1327.2000.01673.x"},{"key":"e_1_3_2_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chembiol.2003.11.010"},{"key":"e_1_3_2_50_1","doi-asserted-by":"publisher","DOI":"10.1124\/dmd.114.062745"},{"key":"e_1_3_2_51_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd1719"},{"key":"e_1_3_2_52_1","doi-asserted-by":"publisher","DOI":"10.1002\/acn3.19"},{"key":"e_1_3_2_53_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd3248"},{"key":"e_1_3_2_54_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2377-12-36"},{"key":"e_1_3_2_55_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.181.1.338"},{"key":"e_1_3_2_56_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms7442"},{"key":"e_1_3_2_57_1","doi-asserted-by":"publisher","DOI":"10.1021\/acschemneuro.6b00029"},{"key":"e_1_3_2_58_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep02859"},{"key":"e_1_3_2_59_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0026459"},{"key":"e_1_3_2_60_1","doi-asserted-by":"publisher","DOI":"10.1042\/bj3510095"},{"issue":"6","key":"e_1_3_2_61_1","first-page":"2462","article-title":"Inhibition of protein kinase C by tamoxifen","volume":"45","author":"O'Brian CA","year":"1985","unstructured":"O'Brian CA , LiskampRM, SolomonDH, WeinsteinIB. Inhibition of protein kinase C by tamoxifen. Cancer Res.45 (6), 2462\u20132465 (1985).","journal-title":"Cancer Res."},{"key":"e_1_3_2_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-2952(85)90225-4"},{"key":"e_1_3_2_63_1","doi-asserted-by":"publisher","DOI":"10.2165\/00023210-200923070-00003"},{"key":"e_1_3_2_64_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-5618.2007.00530.x"},{"key":"e_1_3_2_65_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3302"},{"key":"e_1_3_2_66_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn.3486"},{"key":"e_1_3_2_67_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm301085w"},{"issue":"2","key":"e_1_3_2_68_1","first-page":"112","article-title":"XL-184, a MET, VEGFR-2 and RET kinase inhibitor for the treatment of thyroid cancer, glioblastoma multiforme and NSCLC","volume":"13","author":"Zhang Y","year":"2010","unstructured":"Zhang Y , GuessousF, KofmanA, SchiffD, AbounaderR. XL-184, a MET, VEGFR-2 and RET kinase inhibitor for the treatment of thyroid cancer, glioblastoma multiforme and NSCLC. IDrugs13 (2), 112\u2013121 (2010).","journal-title":"IDrugs"},{"key":"e_1_3_2_69_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.5b01073"}],"container-title":["Future Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.4155\/fmc-2016-0214","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,23]],"date-time":"2024-05-23T19:51:04Z","timestamp":1716493864000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.tandfonline.com\/doi\/full\/10.4155\/fmc-2016-0214"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,2,8]]},"references-count":67,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2017,3]]}},"alternative-id":["10.4155\/fmc-2016-0214"],"URL":"https:\/\/doi.org\/10.4155\/fmc-2016-0214","relation":{},"ISSN":["1756-8919","1756-8927"],"issn-type":[{"value":"1756-8919","type":"print"},{"value":"1756-8927","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,2,8]]},"assertion":[{"value":"The publishing and review policy for this title is described in its Aims & Scope.","order":1,"name":"peerreview_statement","label":"Peer Review Statement"},{"value":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=ifmc20","URL":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=ifmc20","order":2,"name":"aims_and_scope_url","label":"Aim & Scope"},{"value":"2016-11-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-12-21","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-02-08","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}