{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T12:18:42Z","timestamp":1779884322859,"version":"3.53.1"},"reference-count":98,"publisher":"Informa UK Limited","issue":"13","content-domain":{"domain":["www.tandfonline.com"],"crossmark-restriction":true},"short-container-title":["Future Med. Chem."],"published-print":{"date-parts":[[2019,7]]},"DOI":"10.4155\/fmc-2018-0457","type":"journal-article","created":{"date-parts":[[2019,8,30]],"date-time":"2019-08-30T15:39:36Z","timestamp":1567179576000},"page":"1645-1657","update-policy":"https:\/\/doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":44,"title":["The Increasing Impact of Lethal Mutagenesis of Viruses"],"prefix":"10.1080","volume":"11","author":[{"given":"Celia","family":"Perales","sequence":"first","affiliation":[{"name":"Department of Clinical Microbiology\rIIS-Fundaci\u00f3n Jim\u00e9nez D\u00edaz\rUAM. Av. Reyes Cat\u00f3licos 2\r28040\rMadrid\rSpain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas (CIBERehd) del Instituto de Salud Carlos III\r28029\rMadrid\rSpain"},{"name":"Centro de Biolog\u00eda Molecular \u2018Severo Ochoa\u2019 (CSIC-UAM)\rConsejo Superior de Investigaciones Cient\u00edficas (CSIC)\rCampus de Cantoblanco\r28049\rMadrid\rSpain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabel","family":"Gallego","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas (CIBERehd) del Instituto de Salud Carlos III\r28029\rMadrid\rSpain"},{"name":"Centro de Biolog\u00eda Molecular \u2018Severo Ochoa\u2019 (CSIC-UAM)\rConsejo Superior de Investigaciones Cient\u00edficas (CSIC)\rCampus de Cantoblanco\r28049\rMadrid\rSpain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Isabel","family":"de \u00c1vila","sequence":"additional","affiliation":[{"name":"Centro de Biolog\u00eda Molecular \u2018Severo Ochoa\u2019 (CSIC-UAM)\rConsejo Superior de Investigaciones Cient\u00edficas (CSIC)\rCampus de Cantoblanco\r28049\rMadrid\rSpain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Eugenia","family":"Soria","sequence":"additional","affiliation":[{"name":"Centro de Biolog\u00eda Molecular \u2018Severo Ochoa\u2019 (CSIC-UAM)\rConsejo Superior de Investigaciones Cient\u00edficas (CSIC)\rCampus de Cantoblanco\r28049\rMadrid\rSpain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josep","family":"Gregori","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas (CIBERehd) del Instituto de Salud Carlos III\r28029\rMadrid\rSpain"},{"name":"Liver Unit\rInternal Medicine Hospital Universitari Vall d'Hebron\rVall d'Hebron Institut de Recerca (VHIR)\rBarcelona\rSpain"},{"name":"Roche Diagnostics\rS.L.\rSant Cugat del Vall\u00e9s\r08174\rBarcelona\rSpain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josep","family":"Quer","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas (CIBERehd) del Instituto de Salud Carlos III\r28029\rMadrid\rSpain"},{"name":"Liver Unit\rInternal Medicine Hospital Universitari Vall d'Hebron\rVall d'Hebron Institut de Recerca (VHIR)\rBarcelona\rSpain"},{"name":"Universitat Aut\u00f3noma deBarcelona\r08193\rBarcelona\rSpain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esteban","family":"Domingo","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas (CIBERehd) del Instituto de Salud Carlos III\r28029\rMadrid\rSpain"},{"name":"Centro de Biolog\u00eda Molecular \u2018Severo Ochoa\u2019 (CSIC-UAM)\rConsejo Superior de Investigaciones Cient\u00edficas (CSIC)\rCampus de Cantoblanco\r28049\rMadrid\rSpain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2019,8,30]]},"reference":[{"key":"e_1_3_2_3_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.7041255"},{"key":"e_1_3_2_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-0348-9146-2_5"},{"key":"e_1_3_2_5_1","doi-asserted-by":"publisher","DOI":"10.1128\/MMBR.05023-11"},{"key":"e_1_3_2_6_1","first-page":"479","article-title":"Viral quasispecies","author":"Andino R","year":"2015","unstructured":"Andino R , DomingoE. Viral quasispecies. Virology479\u201348046\u201351 (2015).","journal-title":"Virology"},{"key":"e_1_3_2_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00249-018-1282-6"},{"key":"e_1_3_2_8_1","doi-asserted-by":"publisher","DOI":"10.1128\/MMBR.00067-17"},{"key":"e_1_3_2_9_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.49.4.517"},{"key":"e_1_3_2_10_1","volume-title":"The Hypercycle. A Principle of Natural Self-organization.","author":"Eigen M","year":"1979","unstructured":"Eigen M , SchusterP. The Hypercycle. A Principle of Natural Self-organization.Springer, Berlin, Germany (1979)."},{"key":"e_1_3_2_11_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.96.4.1492"},{"key":"e_1_3_2_12_1","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.64.8.3960-3962.1990"},{"key":"e_1_3_2_13_1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00102-15"},{"key":"e_1_3_2_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coviro.2014.04.011"},{"key":"e_1_3_2_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/82191"},{"key":"e_1_3_2_16_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.46.4.977-981.2002"},{"key":"e_1_3_2_17_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00649-13"},{"key":"e_1_3_2_18_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0068347"},{"key":"e_1_3_2_19_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00487-17"},{"key":"e_1_3_2_20_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.02346-12"},{"key":"e_1_3_2_21_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1002535"},{"key":"e_1_3_2_22_1","doi-asserted-by":"publisher","DOI":"10.1006\/jtbi.2000.2251"},{"key":"e_1_3_2_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/0301-4622(82)87037-3"},{"key":"e_1_3_2_24_1","first-page":"61","article-title":"Quasispecies on fitness landscapes","volume":"392","author":"Schuster P","year":"2016","unstructured":"Schuster P . Quasispecies on fitness landscapes. Domingo E, Schuster P (Eds). Curr. Top. Microbiol. Immunol.392, 61\u2013120 (2016).","journal-title":"Curr. Top. Microbiol. Immunol."},{"key":"e_1_3_2_25_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.74.18.8316-8323.2000"},{"key":"e_1_3_2_26_1","first-page":"161","article-title":"Theories of lethal mutagenesis: from error catastrophe to lethal defection","volume":"392","author":"Tejero H","year":"2016","unstructured":"Tejero H , MonteroF, NunoJC. Theories of lethal mutagenesis: from error catastrophe to lethal defection. Curr. Top. Microbiol. Immunol.392, 161\u2013179 (2016).","journal-title":"Curr. Top. Microbiol. Immunol."},{"key":"e_1_3_2_27_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01624-06"},{"key":"e_1_3_2_28_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.77.12.7131-7138.2003"},{"key":"e_1_3_2_29_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0408871102"},{"key":"e_1_3_2_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2007.03.074"},{"key":"e_1_3_2_31_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.78.7.3319-3324.2004"},{"key":"e_1_3_2_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-19829-6"},{"key":"e_1_3_2_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coviro.2017.03.013"},{"key":"e_1_3_2_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coviro.2018.07.014"},{"key":"e_1_3_2_35_1","doi-asserted-by":"publisher","DOI":"10.1038\/226325a0"},{"key":"e_1_3_2_36_1","first-page":"151","volume-title":"Virology.","author":"Holland JJ","year":"1990","unstructured":"Holland JJ . Defective viral genomes. In: Virology.FieldsBM, KnipeDM, ChanockRMet al. (Eds). Raven Press, New York, USA, 151\u2013165 (1990)."},{"key":"e_1_3_2_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2005.09.022"},{"key":"e_1_3_2_38_1","doi-asserted-by":"publisher","DOI":"10.1099\/vir.0.049171-0"},{"key":"e_1_3_2_39_1","doi-asserted-by":"publisher","DOI":"10.1534\/genetics.109.106492"},{"key":"e_1_3_2_40_1","doi-asserted-by":"publisher","DOI":"10.3390\/biom4010291"},{"key":"e_1_3_2_41_1","doi-asserted-by":"publisher","DOI":"10.1093\/gbe\/evx075"},{"key":"e_1_3_2_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8240(88)80059-4"},{"key":"e_1_3_2_43_1","doi-asserted-by":"publisher","DOI":"10.1038\/35085569"},{"key":"e_1_3_2_44_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.0010061"},{"key":"e_1_3_2_45_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.75.20.9723-9730.2001"},{"key":"e_1_3_2_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.virol.2005.05.008"},{"key":"e_1_3_2_47_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1000658"},{"key":"e_1_3_2_48_1","doi-asserted-by":"publisher","DOI":"10.3390\/v4112786"},{"key":"e_1_3_2_49_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00581-16"},{"key":"e_1_3_2_50_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01860-14"},{"key":"e_1_3_2_51_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.micro.51.1.151"},{"key":"e_1_3_2_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.virusres.2007.12.021"},{"key":"e_1_3_2_53_1","first-page":"83","article-title":"Virus fitness: concept, qunatification, and application to HIV population dynamics","volume":"299","author":"Qui\u00f1ones-Mateu ME","year":"2006","unstructured":"Qui\u00f1ones-Mateu ME , ArtsE. Virus fitness: concept, qunatification, and application to HIV population dynamics. Curr. Top. Microbiol. Immunol.299, 83\u2013140 (2006).","journal-title":"Curr. Top. Microbiol. Immunol."},{"key":"e_1_3_2_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coviro.2012.07.007"},{"key":"e_1_3_2_55_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.02505-16"},{"key":"e_1_3_2_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.virol.2018.07.030"},{"key":"e_1_3_2_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.virol.2016.03.017"},{"key":"e_1_3_2_58_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0204877"},{"key":"e_1_3_2_59_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.182426999"},{"key":"e_1_3_2_60_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.212514799"},{"key":"e_1_3_2_61_1","first-page":"231","article-title":"Arenavirus quasispecies and their biological implications","volume":"392","author":"Grande-Perez A","year":"2016","unstructured":"Grande-Perez A , MartinV, MorenoH, DeLa Torre JC. Arenavirus quasispecies and their biological implications. Curr. Top. Microbiol. Immunol.392, 231\u2013276 (2016).","journal-title":"Curr. Top. Microbiol. Immunol."},{"key":"e_1_3_2_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0042-6822(02)00046-6"},{"key":"e_1_3_2_63_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00614-11"},{"key":"e_1_3_2_64_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0015135"},{"key":"e_1_3_2_65_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm400653j"},{"key":"e_1_3_2_66_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0006421"},{"key":"e_1_3_2_67_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.03679"},{"key":"e_1_3_2_68_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.02778-12"},{"key":"e_1_3_2_69_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00201-09"},{"key":"e_1_3_2_70_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2015-311000"},{"key":"e_1_3_2_71_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.virusres.2017.03.014"},{"key":"e_1_3_2_72_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.79.16.10451-10459.2005"},{"key":"e_1_3_2_73_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.meegid.2005.05.001"},{"key":"e_1_3_2_74_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi0344681"},{"key":"e_1_3_2_75_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2008.07.033"},{"key":"e_1_3_2_76_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2148-8-207"},{"key":"e_1_3_2_77_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00716-11"},{"key":"e_1_3_2_78_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2006.12.005"},{"key":"e_1_3_2_79_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2007.03.035"},{"key":"e_1_3_2_80_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdy003"},{"key":"e_1_3_2_81_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-018-0238-4"},{"key":"e_1_3_2_82_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.virol.2016.04.023"},{"key":"e_1_3_2_83_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199508173330710"},{"key":"e_1_3_2_84_1","doi-asserted-by":"crossref","unstructured":"Ehrlich P . Address in Pathology on Chemiotherapy. Report from the International Medical Congress London UK 353\u2013359 (1913).","DOI":"10.1136\/bmj.2.2746.353"},{"key":"e_1_3_2_85_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biotechadv.2015.03.009"},{"key":"e_1_3_2_86_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc3063"},{"key":"e_1_3_2_87_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtbi.2003.08.018"},{"key":"e_1_3_2_88_1","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.71.5.3636-3640.1997"},{"key":"e_1_3_2_89_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.111085598"},{"key":"e_1_3_2_90_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0042-6822(03)00144-2"},{"key":"e_1_3_2_91_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.77.1.481-488.2003"},{"key":"e_1_3_2_92_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.antiviral.2005.04.002"},{"key":"e_1_3_2_93_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01406-09"},{"key":"e_1_3_2_94_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0005554"},{"key":"e_1_3_2_95_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2012.03.003"},{"key":"e_1_3_2_96_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0071039"},{"issue":"10","key":"e_1_3_2_97_1","doi-asserted-by":"crossref","first-page":"e0164691","DOI":"10.1371\/journal.pone.0164691","article-title":"Lethal mutagenesis of hepatitis C virus induced by favipiravir","volume":"11","author":"De Avila AI","year":"2016","unstructured":"De Avila AI , GallegoI, SoriaMEet al. Lethal mutagenesis of hepatitis C virus induced by favipiravir. PLoS ONE11(10), e0164691 (2016).","journal-title":"PLoS ONE"},{"key":"e_1_3_2_98_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01400-17"},{"key":"e_1_3_2_99_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00380-18"},{"key":"e_1_3_2_100_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01217-18"}],"container-title":["Future Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.4155\/fmc-2018-0457","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,23]],"date-time":"2024-05-23T19:52:53Z","timestamp":1716493973000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.tandfonline.com\/doi\/full\/10.4155\/fmc-2018-0457"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,7]]},"references-count":98,"journal-issue":{"issue":"13","published-print":{"date-parts":[[2019,7]]}},"alternative-id":["10.4155\/fmc-2018-0457"],"URL":"https:\/\/doi.org\/10.4155\/fmc-2018-0457","relation":{},"ISSN":["1756-8919","1756-8927"],"issn-type":[{"value":"1756-8919","type":"print"},{"value":"1756-8927","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,7]]},"assertion":[{"value":"The publishing and review policy for this title is described in its Aims & Scope.","order":1,"name":"peerreview_statement","label":"Peer Review Statement"},{"value":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=ifmc20","URL":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=ifmc20","order":2,"name":"aims_and_scope_url","label":"Aim & Scope"},{"value":"2018-09-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-03-21","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-08-30","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}