{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T09:45:18Z","timestamp":1790502318318,"version":"4.1.0"},"reference-count":46,"publisher":"Informa UK Limited","issue":"23","content-domain":{"domain":["www.tandfonline.com"],"crossmark-restriction":true},"short-container-title":["Future Med. Chem."],"published-print":{"date-parts":[[2019,12]]},"DOI":"10.4155\/fmc-2018-0467","type":"journal-article","created":{"date-parts":[[2019,11,4]],"date-time":"2019-11-04T12:55:57Z","timestamp":1572872157000},"page":"3029-3045","update-policy":"https:\/\/doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":15,"title":["New Ibuprofen Derivatives as H\n            <sub>2<\/sub>\n            S and NO Donors as Safer Anti-Inflammatory Agents"],"prefix":"10.1080","volume":"11","author":[{"given":"Ghaneya S","family":"Hassan","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Chemistry\rFaculty of Pharmacy\rCairo University\rKasr El-Eini Street\rCairo\r11562\rEgypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gehan H","family":"Hegazy","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Chemistry\rFaculty of Pharmacy\rCairo University\rKasr El-Eini Street\rCairo\r11562\rEgypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noha M","family":"Ibrahim","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Chemistry\rFaculty of Pharmacy\rCairo University\rKasr El-Eini Street\rCairo\r11562\rEgypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samar H","family":"Fahim","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Chemistry\rFaculty of Pharmacy\rCairo University\rKasr El-Eini Street\rCairo\r11562\rEgypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2019,11,4]]},"reference":[{"key":"e_1_3_4_3_1","first-page":"18","article-title":"Epidemiology of NSAID induced gastrointestinal complications","volume":"56","author":"Singh G","year":"1999","unstructured":"Singh G , TriadafilopoulosG. Epidemiology of NSAID induced gastrointestinal complications. J. Rheumatol. Suppl.56, 18\u201324 (1999).","journal-title":"J. Rheumatol. Suppl."},{"key":"e_1_3_4_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2015.01.010"},{"key":"e_1_3_4_5_1","doi-asserted-by":"publisher","DOI":"10.5155\/eurjchem.6.3.254-260.1233"},{"key":"e_1_3_4_6_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2125.2003.01934.x"},{"key":"e_1_3_4_7_1","doi-asserted-by":"publisher","DOI":"10.3109\/0886022X.2012.718953"},{"key":"e_1_3_4_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/pgmj.2005.039586"},{"key":"e_1_3_4_9_1","doi-asserted-by":"publisher","DOI":"10.1039\/C7MD00209B"},{"key":"e_1_3_4_10_1","doi-asserted-by":"publisher","DOI":"10.1039\/C7MD00628D"},{"key":"e_1_3_4_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioorg.2018.08.024"},{"key":"e_1_3_4_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2017.12.045"},{"key":"e_1_3_4_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0950-3579(88)80021-9"},{"issue":"3","key":"e_1_3_4_14_1","first-page":"249","article-title":"NSAIDs-induced gastrointestinal damage. Review","volume":"52","author":"Arroyo M","year":"2006","unstructured":"Arroyo M , LanasA. NSAIDs-induced gastrointestinal damage. Review. Minerva Gastroenterol. Dietol.52(3), 249\u2013259 (2006).","journal-title":"Minerva Gastroenterol. Dietol."},{"issue":"11","key":"e_1_3_4_15_1","first-page":"1151","article-title":"NSAID-induced gastrointestinal damage and the design of GI-sparing NSAIDs","volume":"9","author":"Wallace JL","year":"2008","unstructured":"Wallace JL , VongL. NSAID-induced gastrointestinal damage and the design of GI-sparing NSAIDs. Curr. Opin. Investig. Drugs9(11), 1151\u20131156 (2008).","journal-title":"Curr. Opin. Investig. Drugs"},{"key":"e_1_3_4_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2004.04133.x"},{"key":"e_1_3_4_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2005.02.034"},{"issue":"4","key":"e_1_3_4_18_1","first-page":"231","article-title":"Recommendations for the appropriate use of anti-inflammatory drugs in the era of the coxibs: defining the role of gastroprotective agents","volume":"16","author":"Hunt RH","year":"2002","unstructured":"Hunt RH , BarkunAN, BaronDet al. Recommendations for the appropriate use of anti-inflammatory drugs in the era of the coxibs: defining the role of gastroprotective agents. J. Gastroenterol.16(4), 231\u2013240 (2002).","journal-title":"J. Gastroenterol."},{"key":"e_1_3_4_19_1","doi-asserted-by":"publisher","DOI":"10.1039\/C7MD00111H"},{"key":"e_1_3_4_20_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.02-0211hyp"},{"key":"e_1_3_4_21_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2006.02.033"},{"key":"e_1_3_4_22_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules20059099"},{"key":"e_1_3_4_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tips.2007.09.003"},{"key":"e_1_3_4_24_1","doi-asserted-by":"publisher","DOI":"10.1517\/17460441.2016.1122590"},{"key":"e_1_3_4_25_1","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2011.4351"},{"key":"e_1_3_4_26_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.06-6270fje"},{"key":"e_1_3_4_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.smim.2015.05.004"},{"key":"e_1_3_4_28_1","doi-asserted-by":"publisher","DOI":"10.1136\/mp.55.6.360"},{"key":"e_1_3_4_29_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199312303292706"},{"key":"e_1_3_4_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1054-3589(08)60049-6"},{"key":"e_1_3_4_31_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.38947.697558.AE"},{"key":"e_1_3_4_32_1","doi-asserted-by":"publisher","DOI":"10.1053\/gast.1997.v112.pm9041264"},{"key":"e_1_3_4_33_1","first-page":"1","article-title":"Synthesis, molecular docking and evaluation of anti-inflammatory activity of some 5-alkyl\/aryl 2-amino-1,3,4 thiadiazole derivatives","volume":"8","author":"Katti S","year":"2016","unstructured":"Katti S , YeoleP, JadhavV, PatilV. Synthesis, molecular docking and evaluation of anti-inflammatory activity of some 5-alkyl\/aryl 2-amino-1,3,4 thiadiazole derivatives. Der Pharma Chem.8(9), 1\u20138 (2016).","journal-title":"Der Pharma Chem."},{"key":"e_1_3_4_34_1","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/145028"},{"key":"e_1_3_4_35_1","doi-asserted-by":"publisher","DOI":"10.1021\/cr400131u"},{"key":"e_1_3_4_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2015.04.079"},{"key":"e_1_3_4_37_1","doi-asserted-by":"publisher","DOI":"10.2174\/1573406410666140613154507"},{"key":"e_1_3_4_38_1","doi-asserted-by":"publisher","DOI":"10.1021\/cb400090d"},{"key":"e_1_3_4_39_1","doi-asserted-by":"publisher","DOI":"10.3181\/00379727-111-27849"},{"key":"e_1_3_4_40_1","first-page":"217","article-title":"Effect of encapsulation of flufenamic acid with acrylic resins on Its bioavailability and gastric ulcerogenic activity in rats","volume":"29","author":"Meshali M","year":"1983","unstructured":"Meshali M , El-SabbaghH, FodaA. Effect of encapsulation of flufenamic acid with acrylic resins on Its bioavailability and gastric ulcerogenic activity in rats. Acta Pharm. Technol.29, 217\u2013230 (1983).","journal-title":"Acta Pharm. Technol."},{"key":"e_1_3_4_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(19)34024-7"},{"key":"e_1_3_4_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2014.02.033"},{"key":"e_1_3_4_43_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi010045s"},{"key":"e_1_3_4_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsb.2014.11.005"},{"key":"e_1_3_4_45_1","unstructured":"Chemical Computing Group Inc. Montr\u00e9al . MOE (2015). www.chemcomp.com"},{"key":"e_1_3_4_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tet.2005.08.031"},{"key":"e_1_3_4_47_1","doi-asserted-by":"publisher","DOI":"10.1002\/cjoc.201090244"},{"key":"e_1_3_4_48_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm049082i"}],"container-title":["Future Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.4155\/fmc-2018-0467","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,23]],"date-time":"2024-05-23T19:52:57Z","timestamp":1716493977000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.tandfonline.com\/doi\/full\/10.4155\/fmc-2018-0467"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,11,4]]},"references-count":46,"journal-issue":{"issue":"23","published-print":{"date-parts":[[2019,12]]}},"alternative-id":["10.4155\/fmc-2018-0467"],"URL":"https:\/\/doi.org\/10.4155\/fmc-2018-0467","relation":{},"ISSN":["1756-8919","1756-8927"],"issn-type":[{"value":"1756-8919","type":"print"},{"value":"1756-8927","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,11,4]]},"assertion":[{"value":"The publishing and review policy for this title is described in its Aims & Scope.","order":1,"name":"peerreview_statement","label":"Peer Review Statement"},{"value":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=ifmc20","URL":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=ifmc20","order":2,"name":"aims_and_scope_url","label":"Aim & Scope"},{"value":"2018-09-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-09-04","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-11-04","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}