{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T20:05:16Z","timestamp":1789243516479,"version":"build-2803163510"},"reference-count":73,"publisher":"Informa UK Limited","issue":"9","funder":[{"name":"IT4Neur","award":["ERDF no.CZ.02.1.01\/0.0\/0.0\/18069\/0010054"],"award-info":[{"award-number":["ERDF no.CZ.02.1.01\/0.0\/0.0\/18069\/0010054"]}]},{"name":"Dually Acting Cognitive Enhancers for Palliative Treatment of Alzheimer's Disease","award":["NU20-08-00296"],"award-info":[{"award-number":["NU20-08-00296"]}]},{"name":"\u0160t\u00fadium cytotoxickej altivity nov\u00fdch kumar\u00ednov\u00fdch deriv\u00e1tov modifikovan\u00fdch akrid\u00ednov\u00fdm, takr\u00ednov\u00fdm a antrac\u00e9nov\u00fdm skeletom","award":["Grant 1\/0016\/18"],"award-info":[{"award-number":["Grant 1\/0016\/18"]}]},{"name":"Long-term organization development plan of the Faculty of Military Health Sciences, University of Defence"}],"content-domain":{"domain":["www.tandfonline.com"],"crossmark-restriction":true},"short-container-title":["Future Med. Chem."],"published-print":{"date-parts":[[2021,5]]},"DOI":"10.4155\/fmc-2020-0184","type":"journal-article","created":{"date-parts":[[2021,4,8]],"date-time":"2021-04-08T09:07:01Z","timestamp":1617872821000},"page":"785-804","update-policy":"https:\/\/doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":14,"title":["Design and Synthesis of Novel Tacrine\u2013Indole Hybrids As Potential Multitarget-Directed Ligands for the Treatment of Alzheimer's Disease"],"prefix":"10.1080","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9081-3720","authenticated-orcid":false,"given":"Slavka","family":"Hamulakova","sequence":"first","affiliation":[{"name":"Department of Organic Chemistry\rInstitute of Chemical Sciences\rFaculty of Science\rPJ Safarik University\rMoyzesova 11\rKosice\rSK-041 67\rSlovak Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zuzana","family":"Kudlickova","sequence":"additional","affiliation":[{"name":"Department of Chemistry\rBiochemistry &amp; Biophysics\rUniversity of Veterinary Medicine &amp; Pharmacy\rKomensk\u00e9ho 73\rKosice\r041 81\rSlovak Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ladislav","family":"Janovec","sequence":"additional","affiliation":[{"name":"Department of Organic Chemistry\rInstitute of Chemical Sciences\rFaculty of Science\rPJ Safarik University\rMoyzesova 11\rKosice\rSK-041 67\rSlovak Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4361-7628","authenticated-orcid":false,"given":"Roman","family":"Mezencev","sequence":"additional","affiliation":[{"name":"School of Biological Sciences\rGeorgia Institute of Technology\rKrone Engineered Biosystems Building\r950 Atlantic Drive NW\rAtlanta\rGA\r30332-2000\rUSA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zachery J","family":"Deckner","sequence":"additional","affiliation":[{"name":"School of Biological Sciences\rGeorgia Institute of Technology\rKrone Engineered Biosystems Building\r950 Atlantic Drive NW\rAtlanta\rGA\r30332-2000\rUSA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8934-9051","authenticated-orcid":false,"given":"Yury O","family":"Chernoff","sequence":"additional","affiliation":[{"name":"School of Biological Sciences\rGeorgia Institute of Technology\rKrone Engineered Biosystems Building\r950 Atlantic Drive NW\rAtlanta\rGA\r30332-2000\rUSA"},{"name":"Laboratory of Amyloid Biology\rSt. Petersburg State University\rSt. Petersburg\r199034\rRussia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2034-1860","authenticated-orcid":false,"given":"Jana","family":"Janockova","sequence":"additional","affiliation":[{"name":"Biomedical Research Centre\rUniversity Hospital Hradec Kralove\rSokolska 581\rHradec Kralove\r500 05\rCzech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veronika","family":"Ihnatova","sequence":"additional","affiliation":[{"name":"Biomedical Research Centre\rUniversity Hospital Hradec Kralove\rSokolska 581\rHradec Kralove\r500 05\rCzech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9651-7917","authenticated-orcid":false,"given":"Petr","family":"Bzonek","sequence":"additional","affiliation":[{"name":"Biomedical Research Centre\rUniversity Hospital Hradec Kralove\rSokolska 581\rHradec Kralove\r500 05\rCzech Republic"},{"name":"Department of Toxicology &amp; Military Pharmacy\rFaculty of Military Health Sciences\rUniversity of Defense\rTrebesska 1575\rHradec Kralove\r500 05\rCzech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikola","family":"Novakova","sequence":"additional","affiliation":[{"name":"Biomedical Research Centre\rUniversity Hospital Hradec Kralove\rSokolska 581\rHradec Kralove\r500 05\rCzech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vendula","family":"Hepnarova","sequence":"additional","affiliation":[{"name":"Biomedical Research Centre\rUniversity Hospital Hradec Kralove\rSokolska 581\rHradec Kralove\r500 05\rCzech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martina","family":"Hrabinova","sequence":"additional","affiliation":[{"name":"Department of Toxicology &amp; Military Pharmacy\rFaculty of Military Health Sciences\rUniversity of Defense\rTrebesska 1575\rHradec Kralove\r500 05\rCzech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Jun","sequence":"additional","affiliation":[{"name":"Biomedical Research Centre\rUniversity Hospital Hradec Kralove\rSokolska 581\rHradec Kralove\r500 05\rCzech Republic"},{"name":"Department of Toxicology &amp; Military Pharmacy\rFaculty of Military Health Sciences\rUniversity of Defense\rTrebesska 1575\rHradec Kralove\r500 05\rCzech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Korabecny","sequence":"additional","affiliation":[{"name":"Biomedical Research Centre\rUniversity Hospital Hradec Kralove\rSokolska 581\rHradec Kralove\r500 05\rCzech Republic"},{"name":"Department of Toxicology &amp; Military Pharmacy\rFaculty of Military Health Sciences\rUniversity of Defense\rTrebesska 1575\rHradec Kralove\r500 05\rCzech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ondrej","family":"Soukup","sequence":"additional","affiliation":[{"name":"Biomedical Research Centre\rUniversity Hospital Hradec Kralove\rSokolska 581\rHradec Kralove\r500 05\rCzech Republic"},{"name":"Department of Toxicology &amp; Military Pharmacy\rFaculty of Military Health Sciences\rUniversity of Defense\rTrebesska 1575\rHradec Kralove\r500 05\rCzech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9664-1109","authenticated-orcid":false,"given":"Kamil","family":"Kuca","sequence":"additional","affiliation":[{"name":"Biomedical Research Centre\rUniversity Hospital Hradec Kralove\rSokolska 581\rHradec Kralove\r500 05\rCzech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2021,4,8]]},"reference":[{"key":"e_1_3_4_3_1","doi-asserted-by":"publisher","DOI":"10.2174\/138161206778792985"},{"key":"e_1_3_4_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm0796-783"},{"key":"e_1_3_4_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn1434"},{"key":"e_1_3_4_6_1","first-page":"60","article-title":"Treatment of Alzheimer's disease: current and future therapeutic approaches","volume":"1","author":"Cummings JL","year":"2004","unstructured":"Cummings JL . Treatment of Alzheimer's disease: current and future therapeutic approaches. Rev. Neurol. Dis.1, 60\u201369 (2004).","journal-title":"Rev. Neurol. Dis."},{"key":"e_1_3_4_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(03)00502-7"},{"key":"e_1_3_4_8_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.8b00610"},{"key":"e_1_3_4_9_1","doi-asserted-by":"publisher","DOI":"10.1177\/106002809402800612"},{"key":"e_1_3_4_10_1","first-page":"245","article-title":"Once-daily transdermal rivastigmine in the treatment of Alzheimer's disease","volume":"2","author":"Wentrup A","year":"2009","unstructured":"Wentrup A , OertelWH , DodelR. Once-daily transdermal rivastigmine in the treatment of Alzheimer's disease. Drug Des. Devel. Ther.2, 245\u2013254 (2009).","journal-title":"Drug Des. Devel. Ther."},{"key":"e_1_3_4_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/jpi.12006"},{"key":"e_1_3_4_12_1","doi-asserted-by":"publisher","DOI":"10.2174\/1570159X1203140511153200"},{"key":"e_1_3_4_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/00001756-199903170-00023"},{"key":"e_1_3_4_14_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.271.39.23646"},{"key":"e_1_3_4_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2004.07.005"},{"key":"e_1_3_4_16_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules18032878"},{"key":"e_1_3_4_17_1","doi-asserted-by":"publisher","DOI":"10.2174\/1874104501711010024"},{"key":"e_1_3_4_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11696-018-0590-8"},{"key":"e_1_3_4_19_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules18066620"},{"key":"e_1_3_4_20_1","doi-asserted-by":"publisher","DOI":"10.1039\/c1np00020a"},{"key":"e_1_3_4_21_1","doi-asserted-by":"publisher","DOI":"10.1039\/C2SC21185H"},{"key":"e_1_3_4_22_1","doi-asserted-by":"publisher","DOI":"10.5155\/eurjchem.3.1.26-31.503"},{"key":"e_1_3_4_23_1","doi-asserted-by":"publisher","DOI":"10.1385\/JMN:30:1:85"},{"key":"e_1_3_4_24_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules17054811"},{"key":"e_1_3_4_25_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm0503289"},{"key":"e_1_3_4_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phytol.2011.07.008"},{"key":"e_1_3_4_27_1","first-page":"449","article-title":"Synthesis of novel N-benzyl substituted piperidine amides of 1H-indole-5-carboxylicacid as potential inhibitors of cholinesterases","volume":"69","author":"Jakubowska A","year":"2012","unstructured":"Jakubowska A , KuligK , GuziorN , MalawskaB. Synthesis of novel N-benzyl substituted piperidine amides of 1H-indole-5-carboxylicacid as potential inhibitors of cholinesterases. Acta Pol. Pharm. Drug Res.69, 449\u2013455 (2012).","journal-title":"Acta Pol. Pharm. Drug Res."},{"key":"e_1_3_4_28_1","doi-asserted-by":"publisher","DOI":"10.2174\/15701808113106660078"},{"key":"e_1_3_4_29_1","doi-asserted-by":"publisher","DOI":"10.1021\/acschemneuro.7b00259"},{"key":"e_1_3_4_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/cmdc.201800156"},{"key":"e_1_3_4_31_1","doi-asserted-by":"publisher","DOI":"10.3390\/md16100386"},{"key":"e_1_3_4_32_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.7b01417"},{"key":"e_1_3_4_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2019.02.021"},{"key":"e_1_3_4_34_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm0503289"},{"key":"e_1_3_4_35_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm050746d"},{"key":"e_1_3_4_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2014.06.064"},{"key":"e_1_3_4_37_1","doi-asserted-by":"publisher","DOI":"10.1080\/14756366.2019.1593159"},{"key":"e_1_3_4_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-2952(61)90145-9"},{"key":"e_1_3_4_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.talanta.2009.12.052"},{"key":"e_1_3_4_40_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms140816882"},{"key":"e_1_3_4_41_1","doi-asserted-by":"publisher","DOI":"10.1093\/genetics\/147.2.507"},{"key":"e_1_3_4_42_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M609597200"},{"key":"e_1_3_4_43_1","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a023663"},{"key":"e_1_3_4_44_1","doi-asserted-by":"publisher","DOI":"10.4149\/neo_2018_170116N37"},{"key":"e_1_3_4_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0223-5234(03)00012-6"},{"key":"e_1_3_4_46_1","unstructured":"ACD\/Labs . ACD\/Labs release 11.00 product version 11.02."},{"key":"e_1_3_4_47_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcc.20084"},{"key":"e_1_3_4_48_1","first-page":"5.6.1","article-title":"Comparative protein structure modeling using modeller","author":"Webb B","year":"2016","unstructured":"Webb B , SaliA. Comparative protein structure modeling using modeller. Curr Protoc Bioinformatics5.6.1\u20135.6.37 (2016).","journal-title":"Curr Protoc Bioinformatics"},{"key":"e_1_3_4_49_1","first-page":"57","article-title":"Python: a programming language for software integration and development","volume":"17","author":"Sanner MF","year":"1999","unstructured":"Sanner MF . Python: a programming language for software integration and development. J. Mol. Graphics Modell.17, 57\u201361 (1999).","journal-title":"J. Mol. Graphics Modell."},{"key":"e_1_3_4_50_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcc.20634"},{"key":"e_1_3_4_51_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-987X(19981115)19:14<1639::AID-JCC10>3.0.CO;2-B"},{"key":"e_1_3_4_52_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcc.20289"},{"key":"e_1_3_4_53_1","doi-asserted-by":"publisher","DOI":"10.1063\/1.445869"},{"key":"e_1_3_4_54_1","doi-asserted-by":"publisher","DOI":"10.1002\/1096-987X(200009)21:12<1049::AID-JCC3>3.0.CO;2-F"},{"key":"e_1_3_4_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmgm.2005.12.005"},{"key":"e_1_3_4_56_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcc.20035"},{"key":"e_1_3_4_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/0263-7855(96)00018-5"},{"key":"e_1_3_4_58_1","unstructured":"Maestro version 10.3.015 MMshare version 3.1.015 release 2015\u20133. https:\/\/www.schrodinger.com\/products\/maestro"},{"key":"e_1_3_4_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2008.08.076"},{"key":"e_1_3_4_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2014.11.014"},{"key":"e_1_3_4_61_1","doi-asserted-by":"publisher","DOI":"10.1039\/p19780001117"},{"key":"e_1_3_4_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2013.12.003"},{"key":"e_1_3_4_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0040-4020(98)00088-X"},{"key":"e_1_3_4_64_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M117.809004"},{"key":"e_1_3_4_65_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-015-9301-4"},{"key":"e_1_3_4_66_1","doi-asserted-by":"publisher","DOI":"10.1177\/1756285611404470"},{"key":"e_1_3_4_67_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules17067067"},{"key":"e_1_3_4_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mrfmmm.2007.03.014"},{"key":"e_1_3_4_69_1","doi-asserted-by":"publisher","DOI":"10.2174\/0929867053363414"},{"key":"e_1_3_4_70_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpj.2014.06.024"},{"issue":"1","key":"e_1_3_4_71_1","first-page":"1","article-title":"History and progress of hypotheses and clinical trials for Alzheimer's disease","volume":"4","author":"Liu P-P","year":"2019","unstructured":"Liu P-P , XieY , MengX-Y , KangJ-S. History and progress of hypotheses and clinical trials for Alzheimer's disease. Signal Transduct. Target. Ther.4(1), 1\u201322 (2019).","journal-title":"Signal Transduct. Target. Ther."},{"key":"e_1_3_4_72_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm058225d"},{"key":"e_1_3_4_73_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm7009364"},{"key":"e_1_3_4_74_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm901692q"},{"key":"e_1_3_4_75_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2008.06.053"}],"container-title":["Future Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.4155\/fmc-2020-0184","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,23]],"date-time":"2024-05-23T19:50:57Z","timestamp":1716493857000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.tandfonline.com\/doi\/full\/10.4155\/fmc-2020-0184"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4,8]]},"references-count":73,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2021,5]]}},"alternative-id":["10.4155\/fmc-2020-0184"],"URL":"https:\/\/doi.org\/10.4155\/fmc-2020-0184","relation":{},"ISSN":["1756-8919","1756-8927"],"issn-type":[{"value":"1756-8919","type":"print"},{"value":"1756-8927","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,4,8]]},"assertion":[{"value":"The publishing and review policy for this title is described in its Aims & Scope.","order":1,"name":"peerreview_statement","label":"Peer Review Statement"},{"value":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=ifmc20","URL":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=ifmc20","order":2,"name":"aims_and_scope_url","label":"Aim & Scope"},{"value":"2020-06-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-02-12","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-04-08","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}